Taubman, Bruce; Rosen, Florence; McHugh, Jennifer; Grady, Matthew F; Elci, Okan U
The timing of cognitive and physical rest and recovery in concussion Journal Article
In: Journal of Child Neurology, vol. 31, no. 14, pp. 1555–1560, 2016, ISBN: 0883-0738 1708-8283.
Abstract | Links | BibTeX | Tags: 2016, brain concussion, Cognitive Ability, Cognitive rest, Concussion, MANAGEMENT, PHYSICAL ACTIVITY, Physical rest, Recovery
@article{Taubman2016,
title = {The timing of cognitive and physical rest and recovery in concussion},
author = {Taubman, Bruce and Rosen, Florence and McHugh, Jennifer and Grady, Matthew F and Elci, Okan U},
doi = {10.1177/0883073816664835},
isbn = {0883-0738
1708-8283},
year = {2016},
date = {2016-01-01},
journal = {Journal of Child Neurology},
volume = {31},
number = {14},
pages = {1555--1560},
publisher = {Sage Publications},
address = {US},
abstract = {Immediate cognitive and physical rest in the concussed patient is almost universally recommended in the concussion literature. The authors conducted a prospective observational in a primary care pediatric office to examine the effect of delayed cognitive and physical rest had on recovery time in pediatric concussion. The authors found that patients who started cognitive and physical rest immediately after injury were more likely to recover within 30 days compared to patients who delayed cognitive and physical rest for 1-7 days after their injury (67% vs 35%},
keywords = {2016, brain concussion, Cognitive Ability, Cognitive rest, Concussion, MANAGEMENT, PHYSICAL ACTIVITY, Physical rest, Recovery},
pubstate = {published},
tppubtype = {article}
}
Lawrence, D W; Comper, P; Hutchison, M G; Sharma, B
The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1018–1031, 2015.
Abstract | Links | BibTeX | Tags: 80 and over, aged, allele, Alleles, Alzheimer disease, amyloid beta protein, APOE, apolipoprotein E, apolipoprotein E4, Article, athlete, brain concussion, Brain Injuries, clinical evaluation, cognition, cognitive defect, disease severity, Female, follow up, genetic association, genetic risk, genetics, GENOTYPE, Glasgow Outcome Scale, heterozygote, histopathology, homozygote, human, Humans, Incidence, injury severity, Male, Memory, nerve cell necrosis, neuropathology, Neuroprotection, outcome assessment, pediatrics, Prevalence, Prognosis, prognostic assessment, protein function, psychologic test, psychology, Recovery, scoring system, Systematic Review, tau protein, traumatic brain injury, treatment outcome, very elderly, Wechsler Intelligence Scale
@article{Lawrence2015,
title = {The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review},
author = {Lawrence, D W and Comper, P and Hutchison, M G and Sharma, B},
doi = {10.3109/02699052.2015.1005131},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1018--1031},
abstract = {Background: The apolipoprotein E gene (APOE) has emerged as a candidate for prognosticating traumatic brain injury (TBI) recovery, with APOE$epsilon$4 identified as a susceptibility marker for poor outcome, despite large discrepancy in its reported influence post-TBI.Methods: A systematic review was conducted, including all primary articles investigating the role of APOE$epsilon$4 on TBI outcome. A total of 65 studies were included, including 24 predominantly investigating mild (mTBI), seven moderate (modTBI) and 33 severe (sTBI); severity was not reported in one study.Results: In mTBI studies, the association between APOE$epsilon$4 and post-TBI outcome was concluded as non-contributory in 14 studies (58.3%), hazardous in nine (37.5%) and protective in one (4.2%). In sTBI studies, the role of APOE$epsilon$4 was hazardous in 21 (63.6%), non-contributory in nine (27.3%) and protective in three (9.1%). Of the seven studies investigating dementia outcomes, four observed a hazardous association with APOE$epsilon$4, while three reported no association. Six studies examined Alzheimers dementia pathology, of which three reported a hazardous influence of APOE$epsilon$4.Conclusions: The influence of APOE$epsilon$4 on neuropsychological testing, functional outcome and in paediatric populations was incongruous. This review supports the majority of research indicating APOE$epsilon$4 adversely influences recovery following TBI, particularly with respect to dementia-related outcomes and outcomes following sTBI. © 2015 Taylor \& Francis Group, LLC.},
keywords = {80 and over, aged, allele, Alleles, Alzheimer disease, amyloid beta protein, APOE, apolipoprotein E, apolipoprotein E4, Article, athlete, brain concussion, Brain Injuries, clinical evaluation, cognition, cognitive defect, disease severity, Female, follow up, genetic association, genetic risk, genetics, GENOTYPE, Glasgow Outcome Scale, heterozygote, histopathology, homozygote, human, Humans, Incidence, injury severity, Male, Memory, nerve cell necrosis, neuropathology, Neuroprotection, outcome assessment, pediatrics, Prevalence, Prognosis, prognostic assessment, protein function, psychologic test, psychology, Recovery, scoring system, Systematic Review, tau protein, traumatic brain injury, treatment outcome, very elderly, Wechsler Intelligence Scale},
pubstate = {published},
tppubtype = {article}
}
Vagnozzi, Roberto; Signoretti, Stefano; Cristofori, Luciano; Alessandrini, Franco; Floris, Roberto; Isgrò, Eugenio; Ria, Antonio; Marziali, Simone; Zoccatelli, Giada; Tavazzi, Barbara; Del Bolgia, Franco; Sorge, Roberto; Broglio, Steven P; McIntosh, Tracy K; Lazzarino, Giuseppe
Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients: Corrigendum Journal Article
In: Brain: A Journal of Neurology, vol. 136, no. 11, pp. e262–e262, 2013, ISBN: 0006-8950 1460-2156.
Abstract | BibTeX | Tags: 2013, Athletes, brain concussion, BRAIN damage, Concussion, Magnetic Resonance Spectroscopy, metabolic brain damage, mild traumatic brain injury, NEUROCHEMISTRY, Recovery, Recovery (Disorders), Spectroscopy, traumatic brain injury
@article{Vagnozzi2013a,
title = {Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients: Corrigendum},
author = {Vagnozzi, Roberto and Signoretti, Stefano and Cristofori, Luciano and Alessandrini, Franco and Floris, Roberto and Isgr\`{o}, Eugenio and Ria, Antonio and Marziali, Simone and Zoccatelli, Giada and Tavazzi, Barbara and {Del Bolgia}, Franco and Sorge, Roberto and Broglio, Steven P and McIntosh, Tracy K and Lazzarino, Giuseppe},
isbn = {0006-8950
1460-2156},
year = {2013},
date = {2013-01-01},
journal = {Brain: A Journal of Neurology},
volume = {136},
number = {11},
pages = {e262--e262},
abstract = {Reports an error in 'Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients' by Roberto Vagnozzi, Stefano Signoretti, Luciano Cristofori, Franco Alessandrini, Roberto Floris, Eugenio Isgr\`{o}, Antonio Ria, Simone Marziale, Giada Zoccatelli, Barbara Tavazzi, Franco Del Bolgia, Roberto Sorge, Steven P. Broglio, Tracy K. McIntosh and Giuseppe Lazzarino (Brain: A Journal of Neurology, 2010[Nov], Vol 133[11], 3232-3242). In the original article, the eighth author’s surname was incorrectly given as ‘Marziale’. The corrected surname of the eighth author is present in the erratum. (The following abstract of the original article appeared in record [rid]2010-23062-009[/rid]). Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact syndrome. To corroborate the validity of proton magnetic resonance spectroscopy in monitoring cerebral metabolic changes following mild traumatic brain injury, apart from the magnetic field strength (1.5 or 3.0 T) and mode of acquisition, we undertook a multicentre prospective study in which a cohort of 40 athletes suffering from concussion and a group of 30 control healthy subjects were admitted. Athletes (aged 16\textendash35 years) were recruited and examined at three different institutions between September 2007 and June 2009. They underwent assessment of brain metabolism at 3, 15, 22 and 30 days post-injury through proton magnetic resonance spectroscopy for the determination of N-acetylaspartate, creatine and choline-containing compounds. Values of these representative brain metabolites were compared with those observed in the group of non-injured controls. Comparison of spectroscopic data, obtained in controls using different field strength and/or mode of acquisition, did not show any difference in the brain metabolite ratios. Athletes with concussion exhibited the most significant alteration of metabolite ratios at Day 3 post-injury (N-acetylaspartate/creatine: −17.6%, N-acetylaspartate/choline: −21.4%; P \< 0.001 with respect to controls). On average, metabolic disturbance gradually recovered, initially in a slow fashion and, following Day 15, more rapidly. At 30 days post-injury, all athletes showed complete recovery, having metabolite ratios returned to values detected in controls. Athletes self-declared symptom clearance between 3 and 15 days after concussion. Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury. In particular, this metabolic evaluation may significantly improve, along with other clinical assessments, the management of athletes suffering from concussion. Further studies to verify the effects of a second concussive event occurring at different time points of the recovery curve of brain metabolism are needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2013, Athletes, brain concussion, BRAIN damage, Concussion, Magnetic Resonance Spectroscopy, metabolic brain damage, mild traumatic brain injury, NEUROCHEMISTRY, Recovery, Recovery (Disorders), Spectroscopy, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Barlow, Michael; Schlabach, Drew; Peiffer, Jeffrey; Cook, Chad
Differences in change scores and the predictive validity of three commonly used measures following concussion in the middle school and high school aged population...[corrected] [published erratum appears in INT J SPORTS PHYS THER 2011; 6(4):1p] Journal Article
In: International Journal of Sports Physical Therapy, vol. 6, no. 3, pp. 150–157, 2011, ISBN: 2159-2896.
Abstract | BibTeX | Tags: ADOLESCENCE, adult, Brain Concussion -- Diagnosis, Child, Data Analysis Software, Disability Evaluation, Female, human, Instrument Validation, Male, Middle, Ohio, Postconcussion Syndrome -- Risk Factors, Predictive Value of Tests, Record Review, Recovery, Retrospective Design, ROC Curve, Scales, Schools, Secondary, validity
@article{Barlow2011,
title = {Differences in change scores and the predictive validity of three commonly used measures following concussion in the middle school and high school aged population...[corrected] [published erratum appears in INT J SPORTS PHYS THER 2011; 6(4):1p]},
author = {Barlow, Michael and Schlabach, Drew and Peiffer, Jeffrey and Cook, Chad},
isbn = {2159-2896},
year = {2011},
date = {2011-01-01},
journal = {International Journal of Sports Physical Therapy},
volume = {6},
number = {3},
pages = {150--157},
publisher = {North American Journal of Sports Physical Therapy},
address = {Indianapolis, Indiana},
abstract = {Background: A battery of tests is commonly used to measure disability with and recovery from concussion. A number of different concussion-oriented assessment tests exist and each is considered useful. To the authors' knowledge, no study has compared the scores of these tests during recovery in the middle school and high school aged population to see how each change over time. Purpose: The purposes of this study were to analyze clinical data of concussed middle school and high school aged athletes to determine the concurrent and predictive validity for post-concussion syndrome (PCS) of the Post-Concussion Symptom Scale (PCSS), Balance Error Scoring System (BESS), and the five subscales of the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). Methods: The study was a retrospective chart review performed on middle school and high school aged individuals with a diagnosis of concussion from the years 2008-2010 within the Akron Children's Hospital Sports Medicine system. To be eligible for inclusion in the dataset, each subject required a baseline measurement for each of the three tests (and all five subscales of the ImPACT) and a post-test measure. The mean age of the population was 15.38 years (SD=1.7) and ranged from 11 to 19 years. Pearson product correlation tests (correlation matrix) were used to analyze the concurrent validity of the test items during recovery following a concussion. Receiver operating characteristics (ROC) curves were used to determine the predictive validity of initial scores for developing PCS. Results: The correlation matrix captured five statistically significant findings; however, these suggested only weak to mild correlations. Five test items yielded an area under the curve (AUC) greater than 0.50 but only one was statistically significant. After qualitative evaluation, only one of the three tests (including the five subscales of the ImPACT) was useful in predicting post-concussion syndrome. Conclusion: This study suggests that there is poor concurrent validity among three commonly used concussion tests and there is no baseline score that predicts whether post-concussion syndrome will occur.},
keywords = {ADOLESCENCE, adult, Brain Concussion -- Diagnosis, Child, Data Analysis Software, Disability Evaluation, Female, human, Instrument Validation, Male, Middle, Ohio, Postconcussion Syndrome -- Risk Factors, Predictive Value of Tests, Record Review, Recovery, Retrospective Design, ROC Curve, Scales, Schools, Secondary, validity},
pubstate = {published},
tppubtype = {article}
}
Quintana, E C
[Commentary on] Recovery from mild concussion in high school athletes Journal Article
In: Annals of Emergency Medicine, vol. 43, no. 5, pp. 680–681, 2004, ISBN: 0196-0644.
BibTeX | Tags: Athletes, brain concussion, Cognition Disorders -- Etiology, high school, Recovery
@article{Quintana2004,
title = {[Commentary on] Recovery from mild concussion in high school athletes},
author = {Quintana, E C},
isbn = {0196-0644},
year = {2004},
date = {2004-01-01},
journal = {Annals of Emergency Medicine},
volume = {43},
number = {5},
pages = {680--681},
publisher = {Elsevier Science},
address = {New York, New York},
keywords = {Athletes, brain concussion, Cognition Disorders -- Etiology, high school, Recovery},
pubstate = {published},
tppubtype = {article}
}
Jackson, P
Concussion in sport Journal Article
In: SportEX Medicine, no. 2, pp. 28–31, 1999, ISBN: 14718138.
Abstract | BibTeX | Tags: *Athletes, *BRAIN -- Concussion, *DIAGNOSIS, *WOUNDS & injuries, METHODOLOGY, Recovery, Return to Play, Second impact syndrome, Testing
@article{Jackson1999,
title = {Concussion in sport},
author = {Jackson, P},
isbn = {14718138},
year = {1999},
date = {1999-01-01},
journal = {SportEX Medicine},
number = {2},
pages = {28--31},
address = {;},
abstract = {Written by one of the UK's top rugby doctors and SportEX Medicine advisor, Dr Paul Jackson, this article reviews the symptoms of concussion, immediate assessment, grading, post-concussion symptoms, guidance for returning to play, second impact syndrome, indications for urgent referral, concusive/impact convulsions, recurrent concussion and briefly outlines the future of tests of brain function. Practical elements such as questions to ask to test recent memory and likely responses from both the concussed and non-concussed individual are also included.},
keywords = {*Athletes, *BRAIN -- Concussion, *DIAGNOSIS, *WOUNDS \& injuries, METHODOLOGY, Recovery, Return to Play, Second impact syndrome, Testing},
pubstate = {published},
tppubtype = {article}
}
Jagger, J A
Neurobiofeedback: an alternative approach for chronic post-concussion syndrome Journal Article
In: Sports Medicine in Primary Care, vol. 4, no. 5, pp. 40–41, 1998, ISBN: 10629297.
BibTeX | Tags: *BIOLOGICAL control systems, *BRAIN -- Concussion, *REHABILITATION, Biofeedback, Psychotherapy, Recovery, Second impact syndrome
@article{Jagger1998,
title = {Neurobiofeedback: an alternative approach for chronic post-concussion syndrome},
author = {Jagger, J A},
isbn = {10629297},
year = {1998},
date = {1998-01-01},
journal = {Sports Medicine in Primary Care},
volume = {4},
number = {5},
pages = {40--41},
address = {;},
keywords = {*BIOLOGICAL control systems, *BRAIN -- Concussion, *REHABILITATION, Biofeedback, Psychotherapy, Recovery, Second impact syndrome},
pubstate = {published},
tppubtype = {article}
}
Taubman, Bruce; Rosen, Florence; McHugh, Jennifer; Grady, Matthew F; Elci, Okan U
The timing of cognitive and physical rest and recovery in concussion Journal Article
In: Journal of Child Neurology, vol. 31, no. 14, pp. 1555–1560, 2016, ISBN: 0883-0738 1708-8283.
@article{Taubman2016,
title = {The timing of cognitive and physical rest and recovery in concussion},
author = {Taubman, Bruce and Rosen, Florence and McHugh, Jennifer and Grady, Matthew F and Elci, Okan U},
doi = {10.1177/0883073816664835},
isbn = {0883-0738
1708-8283},
year = {2016},
date = {2016-01-01},
journal = {Journal of Child Neurology},
volume = {31},
number = {14},
pages = {1555--1560},
publisher = {Sage Publications},
address = {US},
abstract = {Immediate cognitive and physical rest in the concussed patient is almost universally recommended in the concussion literature. The authors conducted a prospective observational in a primary care pediatric office to examine the effect of delayed cognitive and physical rest had on recovery time in pediatric concussion. The authors found that patients who started cognitive and physical rest immediately after injury were more likely to recover within 30 days compared to patients who delayed cognitive and physical rest for 1-7 days after their injury (67% vs 35%},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Lawrence, D W; Comper, P; Hutchison, M G; Sharma, B
The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1018–1031, 2015.
@article{Lawrence2015,
title = {The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review},
author = {Lawrence, D W and Comper, P and Hutchison, M G and Sharma, B},
doi = {10.3109/02699052.2015.1005131},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1018--1031},
abstract = {Background: The apolipoprotein E gene (APOE) has emerged as a candidate for prognosticating traumatic brain injury (TBI) recovery, with APOE$epsilon$4 identified as a susceptibility marker for poor outcome, despite large discrepancy in its reported influence post-TBI.Methods: A systematic review was conducted, including all primary articles investigating the role of APOE$epsilon$4 on TBI outcome. A total of 65 studies were included, including 24 predominantly investigating mild (mTBI), seven moderate (modTBI) and 33 severe (sTBI); severity was not reported in one study.Results: In mTBI studies, the association between APOE$epsilon$4 and post-TBI outcome was concluded as non-contributory in 14 studies (58.3%), hazardous in nine (37.5%) and protective in one (4.2%). In sTBI studies, the role of APOE$epsilon$4 was hazardous in 21 (63.6%), non-contributory in nine (27.3%) and protective in three (9.1%). Of the seven studies investigating dementia outcomes, four observed a hazardous association with APOE$epsilon$4, while three reported no association. Six studies examined Alzheimers dementia pathology, of which three reported a hazardous influence of APOE$epsilon$4.Conclusions: The influence of APOE$epsilon$4 on neuropsychological testing, functional outcome and in paediatric populations was incongruous. This review supports the majority of research indicating APOE$epsilon$4 adversely influences recovery following TBI, particularly with respect to dementia-related outcomes and outcomes following sTBI. © 2015 Taylor \& Francis Group, LLC.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Vagnozzi, Roberto; Signoretti, Stefano; Cristofori, Luciano; Alessandrini, Franco; Floris, Roberto; Isgrò, Eugenio; Ria, Antonio; Marziali, Simone; Zoccatelli, Giada; Tavazzi, Barbara; Del Bolgia, Franco; Sorge, Roberto; Broglio, Steven P; McIntosh, Tracy K; Lazzarino, Giuseppe
Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients: Corrigendum Journal Article
In: Brain: A Journal of Neurology, vol. 136, no. 11, pp. e262–e262, 2013, ISBN: 0006-8950 1460-2156.
@article{Vagnozzi2013a,
title = {Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients: Corrigendum},
author = {Vagnozzi, Roberto and Signoretti, Stefano and Cristofori, Luciano and Alessandrini, Franco and Floris, Roberto and Isgr\`{o}, Eugenio and Ria, Antonio and Marziali, Simone and Zoccatelli, Giada and Tavazzi, Barbara and {Del Bolgia}, Franco and Sorge, Roberto and Broglio, Steven P and McIntosh, Tracy K and Lazzarino, Giuseppe},
isbn = {0006-8950
1460-2156},
year = {2013},
date = {2013-01-01},
journal = {Brain: A Journal of Neurology},
volume = {136},
number = {11},
pages = {e262--e262},
abstract = {Reports an error in 'Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients' by Roberto Vagnozzi, Stefano Signoretti, Luciano Cristofori, Franco Alessandrini, Roberto Floris, Eugenio Isgr\`{o}, Antonio Ria, Simone Marziale, Giada Zoccatelli, Barbara Tavazzi, Franco Del Bolgia, Roberto Sorge, Steven P. Broglio, Tracy K. McIntosh and Giuseppe Lazzarino (Brain: A Journal of Neurology, 2010[Nov], Vol 133[11], 3232-3242). In the original article, the eighth author’s surname was incorrectly given as ‘Marziale’. The corrected surname of the eighth author is present in the erratum. (The following abstract of the original article appeared in record [rid]2010-23062-009[/rid]). Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact syndrome. To corroborate the validity of proton magnetic resonance spectroscopy in monitoring cerebral metabolic changes following mild traumatic brain injury, apart from the magnetic field strength (1.5 or 3.0 T) and mode of acquisition, we undertook a multicentre prospective study in which a cohort of 40 athletes suffering from concussion and a group of 30 control healthy subjects were admitted. Athletes (aged 16\textendash35 years) were recruited and examined at three different institutions between September 2007 and June 2009. They underwent assessment of brain metabolism at 3, 15, 22 and 30 days post-injury through proton magnetic resonance spectroscopy for the determination of N-acetylaspartate, creatine and choline-containing compounds. Values of these representative brain metabolites were compared with those observed in the group of non-injured controls. Comparison of spectroscopic data, obtained in controls using different field strength and/or mode of acquisition, did not show any difference in the brain metabolite ratios. Athletes with concussion exhibited the most significant alteration of metabolite ratios at Day 3 post-injury (N-acetylaspartate/creatine: −17.6%, N-acetylaspartate/choline: −21.4%; P \< 0.001 with respect to controls). On average, metabolic disturbance gradually recovered, initially in a slow fashion and, following Day 15, more rapidly. At 30 days post-injury, all athletes showed complete recovery, having metabolite ratios returned to values detected in controls. Athletes self-declared symptom clearance between 3 and 15 days after concussion. Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury. In particular, this metabolic evaluation may significantly improve, along with other clinical assessments, the management of athletes suffering from concussion. Further studies to verify the effects of a second concussive event occurring at different time points of the recovery curve of brain metabolism are needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Barlow, Michael; Schlabach, Drew; Peiffer, Jeffrey; Cook, Chad
Differences in change scores and the predictive validity of three commonly used measures following concussion in the middle school and high school aged population...[corrected] [published erratum appears in INT J SPORTS PHYS THER 2011; 6(4):1p] Journal Article
In: International Journal of Sports Physical Therapy, vol. 6, no. 3, pp. 150–157, 2011, ISBN: 2159-2896.
@article{Barlow2011,
title = {Differences in change scores and the predictive validity of three commonly used measures following concussion in the middle school and high school aged population...[corrected] [published erratum appears in INT J SPORTS PHYS THER 2011; 6(4):1p]},
author = {Barlow, Michael and Schlabach, Drew and Peiffer, Jeffrey and Cook, Chad},
isbn = {2159-2896},
year = {2011},
date = {2011-01-01},
journal = {International Journal of Sports Physical Therapy},
volume = {6},
number = {3},
pages = {150--157},
publisher = {North American Journal of Sports Physical Therapy},
address = {Indianapolis, Indiana},
abstract = {Background: A battery of tests is commonly used to measure disability with and recovery from concussion. A number of different concussion-oriented assessment tests exist and each is considered useful. To the authors' knowledge, no study has compared the scores of these tests during recovery in the middle school and high school aged population to see how each change over time. Purpose: The purposes of this study were to analyze clinical data of concussed middle school and high school aged athletes to determine the concurrent and predictive validity for post-concussion syndrome (PCS) of the Post-Concussion Symptom Scale (PCSS), Balance Error Scoring System (BESS), and the five subscales of the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). Methods: The study was a retrospective chart review performed on middle school and high school aged individuals with a diagnosis of concussion from the years 2008-2010 within the Akron Children's Hospital Sports Medicine system. To be eligible for inclusion in the dataset, each subject required a baseline measurement for each of the three tests (and all five subscales of the ImPACT) and a post-test measure. The mean age of the population was 15.38 years (SD=1.7) and ranged from 11 to 19 years. Pearson product correlation tests (correlation matrix) were used to analyze the concurrent validity of the test items during recovery following a concussion. Receiver operating characteristics (ROC) curves were used to determine the predictive validity of initial scores for developing PCS. Results: The correlation matrix captured five statistically significant findings; however, these suggested only weak to mild correlations. Five test items yielded an area under the curve (AUC) greater than 0.50 but only one was statistically significant. After qualitative evaluation, only one of the three tests (including the five subscales of the ImPACT) was useful in predicting post-concussion syndrome. Conclusion: This study suggests that there is poor concurrent validity among three commonly used concussion tests and there is no baseline score that predicts whether post-concussion syndrome will occur.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Quintana, E C
[Commentary on] Recovery from mild concussion in high school athletes Journal Article
In: Annals of Emergency Medicine, vol. 43, no. 5, pp. 680–681, 2004, ISBN: 0196-0644.
@article{Quintana2004,
title = {[Commentary on] Recovery from mild concussion in high school athletes},
author = {Quintana, E C},
isbn = {0196-0644},
year = {2004},
date = {2004-01-01},
journal = {Annals of Emergency Medicine},
volume = {43},
number = {5},
pages = {680--681},
publisher = {Elsevier Science},
address = {New York, New York},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Jackson, P
Concussion in sport Journal Article
In: SportEX Medicine, no. 2, pp. 28–31, 1999, ISBN: 14718138.
@article{Jackson1999,
title = {Concussion in sport},
author = {Jackson, P},
isbn = {14718138},
year = {1999},
date = {1999-01-01},
journal = {SportEX Medicine},
number = {2},
pages = {28--31},
address = {;},
abstract = {Written by one of the UK's top rugby doctors and SportEX Medicine advisor, Dr Paul Jackson, this article reviews the symptoms of concussion, immediate assessment, grading, post-concussion symptoms, guidance for returning to play, second impact syndrome, indications for urgent referral, concusive/impact convulsions, recurrent concussion and briefly outlines the future of tests of brain function. Practical elements such as questions to ask to test recent memory and likely responses from both the concussed and non-concussed individual are also included.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Jagger, J A
Neurobiofeedback: an alternative approach for chronic post-concussion syndrome Journal Article
In: Sports Medicine in Primary Care, vol. 4, no. 5, pp. 40–41, 1998, ISBN: 10629297.
@article{Jagger1998,
title = {Neurobiofeedback: an alternative approach for chronic post-concussion syndrome},
author = {Jagger, J A},
isbn = {10629297},
year = {1998},
date = {1998-01-01},
journal = {Sports Medicine in Primary Care},
volume = {4},
number = {5},
pages = {40--41},
address = {;},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Taubman, Bruce; Rosen, Florence; McHugh, Jennifer; Grady, Matthew F; Elci, Okan U
The timing of cognitive and physical rest and recovery in concussion Journal Article
In: Journal of Child Neurology, vol. 31, no. 14, pp. 1555–1560, 2016, ISBN: 0883-0738 1708-8283.
Abstract | Links | BibTeX | Tags: 2016, brain concussion, Cognitive Ability, Cognitive rest, Concussion, MANAGEMENT, PHYSICAL ACTIVITY, Physical rest, Recovery
@article{Taubman2016,
title = {The timing of cognitive and physical rest and recovery in concussion},
author = {Taubman, Bruce and Rosen, Florence and McHugh, Jennifer and Grady, Matthew F and Elci, Okan U},
doi = {10.1177/0883073816664835},
isbn = {0883-0738
1708-8283},
year = {2016},
date = {2016-01-01},
journal = {Journal of Child Neurology},
volume = {31},
number = {14},
pages = {1555--1560},
publisher = {Sage Publications},
address = {US},
abstract = {Immediate cognitive and physical rest in the concussed patient is almost universally recommended in the concussion literature. The authors conducted a prospective observational in a primary care pediatric office to examine the effect of delayed cognitive and physical rest had on recovery time in pediatric concussion. The authors found that patients who started cognitive and physical rest immediately after injury were more likely to recover within 30 days compared to patients who delayed cognitive and physical rest for 1-7 days after their injury (67% vs 35%},
keywords = {2016, brain concussion, Cognitive Ability, Cognitive rest, Concussion, MANAGEMENT, PHYSICAL ACTIVITY, Physical rest, Recovery},
pubstate = {published},
tppubtype = {article}
}
Lawrence, D W; Comper, P; Hutchison, M G; Sharma, B
The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1018–1031, 2015.
Abstract | Links | BibTeX | Tags: 80 and over, aged, allele, Alleles, Alzheimer disease, amyloid beta protein, APOE, apolipoprotein E, apolipoprotein E4, Article, athlete, brain concussion, Brain Injuries, clinical evaluation, cognition, cognitive defect, disease severity, Female, follow up, genetic association, genetic risk, genetics, GENOTYPE, Glasgow Outcome Scale, heterozygote, histopathology, homozygote, human, Humans, Incidence, injury severity, Male, Memory, nerve cell necrosis, neuropathology, Neuroprotection, outcome assessment, pediatrics, Prevalence, Prognosis, prognostic assessment, protein function, psychologic test, psychology, Recovery, scoring system, Systematic Review, tau protein, traumatic brain injury, treatment outcome, very elderly, Wechsler Intelligence Scale
@article{Lawrence2015,
title = {The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review},
author = {Lawrence, D W and Comper, P and Hutchison, M G and Sharma, B},
doi = {10.3109/02699052.2015.1005131},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1018--1031},
abstract = {Background: The apolipoprotein E gene (APOE) has emerged as a candidate for prognosticating traumatic brain injury (TBI) recovery, with APOE$epsilon$4 identified as a susceptibility marker for poor outcome, despite large discrepancy in its reported influence post-TBI.Methods: A systematic review was conducted, including all primary articles investigating the role of APOE$epsilon$4 on TBI outcome. A total of 65 studies were included, including 24 predominantly investigating mild (mTBI), seven moderate (modTBI) and 33 severe (sTBI); severity was not reported in one study.Results: In mTBI studies, the association between APOE$epsilon$4 and post-TBI outcome was concluded as non-contributory in 14 studies (58.3%), hazardous in nine (37.5%) and protective in one (4.2%). In sTBI studies, the role of APOE$epsilon$4 was hazardous in 21 (63.6%), non-contributory in nine (27.3%) and protective in three (9.1%). Of the seven studies investigating dementia outcomes, four observed a hazardous association with APOE$epsilon$4, while three reported no association. Six studies examined Alzheimers dementia pathology, of which three reported a hazardous influence of APOE$epsilon$4.Conclusions: The influence of APOE$epsilon$4 on neuropsychological testing, functional outcome and in paediatric populations was incongruous. This review supports the majority of research indicating APOE$epsilon$4 adversely influences recovery following TBI, particularly with respect to dementia-related outcomes and outcomes following sTBI. © 2015 Taylor \& Francis Group, LLC.},
keywords = {80 and over, aged, allele, Alleles, Alzheimer disease, amyloid beta protein, APOE, apolipoprotein E, apolipoprotein E4, Article, athlete, brain concussion, Brain Injuries, clinical evaluation, cognition, cognitive defect, disease severity, Female, follow up, genetic association, genetic risk, genetics, GENOTYPE, Glasgow Outcome Scale, heterozygote, histopathology, homozygote, human, Humans, Incidence, injury severity, Male, Memory, nerve cell necrosis, neuropathology, Neuroprotection, outcome assessment, pediatrics, Prevalence, Prognosis, prognostic assessment, protein function, psychologic test, psychology, Recovery, scoring system, Systematic Review, tau protein, traumatic brain injury, treatment outcome, very elderly, Wechsler Intelligence Scale},
pubstate = {published},
tppubtype = {article}
}
Vagnozzi, Roberto; Signoretti, Stefano; Cristofori, Luciano; Alessandrini, Franco; Floris, Roberto; Isgrò, Eugenio; Ria, Antonio; Marziali, Simone; Zoccatelli, Giada; Tavazzi, Barbara; Del Bolgia, Franco; Sorge, Roberto; Broglio, Steven P; McIntosh, Tracy K; Lazzarino, Giuseppe
Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients: Corrigendum Journal Article
In: Brain: A Journal of Neurology, vol. 136, no. 11, pp. e262–e262, 2013, ISBN: 0006-8950 1460-2156.
Abstract | BibTeX | Tags: 2013, Athletes, brain concussion, BRAIN damage, Concussion, Magnetic Resonance Spectroscopy, metabolic brain damage, mild traumatic brain injury, NEUROCHEMISTRY, Recovery, Recovery (Disorders), Spectroscopy, traumatic brain injury
@article{Vagnozzi2013a,
title = {Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients: Corrigendum},
author = {Vagnozzi, Roberto and Signoretti, Stefano and Cristofori, Luciano and Alessandrini, Franco and Floris, Roberto and Isgr\`{o}, Eugenio and Ria, Antonio and Marziali, Simone and Zoccatelli, Giada and Tavazzi, Barbara and {Del Bolgia}, Franco and Sorge, Roberto and Broglio, Steven P and McIntosh, Tracy K and Lazzarino, Giuseppe},
isbn = {0006-8950
1460-2156},
year = {2013},
date = {2013-01-01},
journal = {Brain: A Journal of Neurology},
volume = {136},
number = {11},
pages = {e262--e262},
abstract = {Reports an error in 'Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients' by Roberto Vagnozzi, Stefano Signoretti, Luciano Cristofori, Franco Alessandrini, Roberto Floris, Eugenio Isgr\`{o}, Antonio Ria, Simone Marziale, Giada Zoccatelli, Barbara Tavazzi, Franco Del Bolgia, Roberto Sorge, Steven P. Broglio, Tracy K. McIntosh and Giuseppe Lazzarino (Brain: A Journal of Neurology, 2010[Nov], Vol 133[11], 3232-3242). In the original article, the eighth author’s surname was incorrectly given as ‘Marziale’. The corrected surname of the eighth author is present in the erratum. (The following abstract of the original article appeared in record [rid]2010-23062-009[/rid]). Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact syndrome. To corroborate the validity of proton magnetic resonance spectroscopy in monitoring cerebral metabolic changes following mild traumatic brain injury, apart from the magnetic field strength (1.5 or 3.0 T) and mode of acquisition, we undertook a multicentre prospective study in which a cohort of 40 athletes suffering from concussion and a group of 30 control healthy subjects were admitted. Athletes (aged 16\textendash35 years) were recruited and examined at three different institutions between September 2007 and June 2009. They underwent assessment of brain metabolism at 3, 15, 22 and 30 days post-injury through proton magnetic resonance spectroscopy for the determination of N-acetylaspartate, creatine and choline-containing compounds. Values of these representative brain metabolites were compared with those observed in the group of non-injured controls. Comparison of spectroscopic data, obtained in controls using different field strength and/or mode of acquisition, did not show any difference in the brain metabolite ratios. Athletes with concussion exhibited the most significant alteration of metabolite ratios at Day 3 post-injury (N-acetylaspartate/creatine: −17.6%, N-acetylaspartate/choline: −21.4%; P \< 0.001 with respect to controls). On average, metabolic disturbance gradually recovered, initially in a slow fashion and, following Day 15, more rapidly. At 30 days post-injury, all athletes showed complete recovery, having metabolite ratios returned to values detected in controls. Athletes self-declared symptom clearance between 3 and 15 days after concussion. Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury. In particular, this metabolic evaluation may significantly improve, along with other clinical assessments, the management of athletes suffering from concussion. Further studies to verify the effects of a second concussive event occurring at different time points of the recovery curve of brain metabolism are needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2013, Athletes, brain concussion, BRAIN damage, Concussion, Magnetic Resonance Spectroscopy, metabolic brain damage, mild traumatic brain injury, NEUROCHEMISTRY, Recovery, Recovery (Disorders), Spectroscopy, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Barlow, Michael; Schlabach, Drew; Peiffer, Jeffrey; Cook, Chad
Differences in change scores and the predictive validity of three commonly used measures following concussion in the middle school and high school aged population...[corrected] [published erratum appears in INT J SPORTS PHYS THER 2011; 6(4):1p] Journal Article
In: International Journal of Sports Physical Therapy, vol. 6, no. 3, pp. 150–157, 2011, ISBN: 2159-2896.
Abstract | BibTeX | Tags: ADOLESCENCE, adult, Brain Concussion -- Diagnosis, Child, Data Analysis Software, Disability Evaluation, Female, human, Instrument Validation, Male, Middle, Ohio, Postconcussion Syndrome -- Risk Factors, Predictive Value of Tests, Record Review, Recovery, Retrospective Design, ROC Curve, Scales, Schools, Secondary, validity
@article{Barlow2011,
title = {Differences in change scores and the predictive validity of three commonly used measures following concussion in the middle school and high school aged population...[corrected] [published erratum appears in INT J SPORTS PHYS THER 2011; 6(4):1p]},
author = {Barlow, Michael and Schlabach, Drew and Peiffer, Jeffrey and Cook, Chad},
isbn = {2159-2896},
year = {2011},
date = {2011-01-01},
journal = {International Journal of Sports Physical Therapy},
volume = {6},
number = {3},
pages = {150--157},
publisher = {North American Journal of Sports Physical Therapy},
address = {Indianapolis, Indiana},
abstract = {Background: A battery of tests is commonly used to measure disability with and recovery from concussion. A number of different concussion-oriented assessment tests exist and each is considered useful. To the authors' knowledge, no study has compared the scores of these tests during recovery in the middle school and high school aged population to see how each change over time. Purpose: The purposes of this study were to analyze clinical data of concussed middle school and high school aged athletes to determine the concurrent and predictive validity for post-concussion syndrome (PCS) of the Post-Concussion Symptom Scale (PCSS), Balance Error Scoring System (BESS), and the five subscales of the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). Methods: The study was a retrospective chart review performed on middle school and high school aged individuals with a diagnosis of concussion from the years 2008-2010 within the Akron Children's Hospital Sports Medicine system. To be eligible for inclusion in the dataset, each subject required a baseline measurement for each of the three tests (and all five subscales of the ImPACT) and a post-test measure. The mean age of the population was 15.38 years (SD=1.7) and ranged from 11 to 19 years. Pearson product correlation tests (correlation matrix) were used to analyze the concurrent validity of the test items during recovery following a concussion. Receiver operating characteristics (ROC) curves were used to determine the predictive validity of initial scores for developing PCS. Results: The correlation matrix captured five statistically significant findings; however, these suggested only weak to mild correlations. Five test items yielded an area under the curve (AUC) greater than 0.50 but only one was statistically significant. After qualitative evaluation, only one of the three tests (including the five subscales of the ImPACT) was useful in predicting post-concussion syndrome. Conclusion: This study suggests that there is poor concurrent validity among three commonly used concussion tests and there is no baseline score that predicts whether post-concussion syndrome will occur.},
keywords = {ADOLESCENCE, adult, Brain Concussion -- Diagnosis, Child, Data Analysis Software, Disability Evaluation, Female, human, Instrument Validation, Male, Middle, Ohio, Postconcussion Syndrome -- Risk Factors, Predictive Value of Tests, Record Review, Recovery, Retrospective Design, ROC Curve, Scales, Schools, Secondary, validity},
pubstate = {published},
tppubtype = {article}
}
Quintana, E C
[Commentary on] Recovery from mild concussion in high school athletes Journal Article
In: Annals of Emergency Medicine, vol. 43, no. 5, pp. 680–681, 2004, ISBN: 0196-0644.
BibTeX | Tags: Athletes, brain concussion, Cognition Disorders -- Etiology, high school, Recovery
@article{Quintana2004,
title = {[Commentary on] Recovery from mild concussion in high school athletes},
author = {Quintana, E C},
isbn = {0196-0644},
year = {2004},
date = {2004-01-01},
journal = {Annals of Emergency Medicine},
volume = {43},
number = {5},
pages = {680--681},
publisher = {Elsevier Science},
address = {New York, New York},
keywords = {Athletes, brain concussion, Cognition Disorders -- Etiology, high school, Recovery},
pubstate = {published},
tppubtype = {article}
}
Jackson, P
Concussion in sport Journal Article
In: SportEX Medicine, no. 2, pp. 28–31, 1999, ISBN: 14718138.
Abstract | BibTeX | Tags: *Athletes, *BRAIN -- Concussion, *DIAGNOSIS, *WOUNDS & injuries, METHODOLOGY, Recovery, Return to Play, Second impact syndrome, Testing
@article{Jackson1999,
title = {Concussion in sport},
author = {Jackson, P},
isbn = {14718138},
year = {1999},
date = {1999-01-01},
journal = {SportEX Medicine},
number = {2},
pages = {28--31},
address = {;},
abstract = {Written by one of the UK's top rugby doctors and SportEX Medicine advisor, Dr Paul Jackson, this article reviews the symptoms of concussion, immediate assessment, grading, post-concussion symptoms, guidance for returning to play, second impact syndrome, indications for urgent referral, concusive/impact convulsions, recurrent concussion and briefly outlines the future of tests of brain function. Practical elements such as questions to ask to test recent memory and likely responses from both the concussed and non-concussed individual are also included.},
keywords = {*Athletes, *BRAIN -- Concussion, *DIAGNOSIS, *WOUNDS \& injuries, METHODOLOGY, Recovery, Return to Play, Second impact syndrome, Testing},
pubstate = {published},
tppubtype = {article}
}
Jagger, J A
Neurobiofeedback: an alternative approach for chronic post-concussion syndrome Journal Article
In: Sports Medicine in Primary Care, vol. 4, no. 5, pp. 40–41, 1998, ISBN: 10629297.
BibTeX | Tags: *BIOLOGICAL control systems, *BRAIN -- Concussion, *REHABILITATION, Biofeedback, Psychotherapy, Recovery, Second impact syndrome
@article{Jagger1998,
title = {Neurobiofeedback: an alternative approach for chronic post-concussion syndrome},
author = {Jagger, J A},
isbn = {10629297},
year = {1998},
date = {1998-01-01},
journal = {Sports Medicine in Primary Care},
volume = {4},
number = {5},
pages = {40--41},
address = {;},
keywords = {*BIOLOGICAL control systems, *BRAIN -- Concussion, *REHABILITATION, Biofeedback, Psychotherapy, Recovery, Second impact syndrome},
pubstate = {published},
tppubtype = {article}
}