Hansen, C; Cushman, D; Chen, W; Bounsanga, J; Hung, M
Reliability testing of the balance error scoring system in children between the ages of 5 and 14 Journal Article
In: Clinical Journal of Sport Medicine, vol. 27, no. 1, pp. 64–68, 2017.
Abstract | Links | BibTeX | Tags: brain concussion, Child, pediatrics, Reproducibility of Results, Sports
@article{Hansen2017,
title = {Reliability testing of the balance error scoring system in children between the ages of 5 and 14},
author = {Hansen, C and Cushman, D and Chen, W and Bounsanga, J and Hung, M},
doi = {10.1097/JSM.0000000000000293},
year = {2017},
date = {2017-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {27},
number = {1},
pages = {64--68},
abstract = {Objective: Pediatric concussion is an extensive public health concern with a complex clinical presentation. Balance assessment has been well-studied in the adult population, but has been limited in children. We aimed to assess the reliability and minimum detectable change (MDC) of the Balance Error Scoring System (BESS) in healthy children. Design: This prospective observational study included 373 healthy children aged 5 to 14. Interrater reliability was assessed by having 4 assessors review videos of 50 random subjects distributed evenly by age and sex across the entire cohort. Intrarater reliability was performed by having assessors review videos of other assessors' live evaluations. Test-retest reliability was obtained by comparing BESS scores as recorded live at the 2 separate time points by the same rater. Setting: Local elementary and junior high schools. Participants: Three hundred and seventy three healthy children between the ages of 5 and 14. Interventions: The BESS was performed on all children. Main Outcome Measures: Intraclass Correlation Coefficients (ICCs) and MDC Scores. Results: The overall interrater ICC was determined to be 0.93 [95% confidence interval (CI), 0.79-0.97] and intrarater ICC was 0.96 (95% CI, 0.95-0.97) with individual intrarater ICCs ranging between 0.69 and 0.99. The test-retest reliability was 0.90 (95% CI, 0.88- 0.92). The MDCs were 9.6, 4.6, and 7.3 points at the 95% CIs for interrater, intrarater, and test-retest comparisons, respectively. No learning effect was seen. Conclusions: The BESS demonstrates excellent reliability in the pediatric population without evidence of a learning effect. © 2016 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {brain concussion, Child, pediatrics, Reproducibility of Results, Sports},
pubstate = {published},
tppubtype = {article}
}
Richards, D; Ivarsson, B J; Scher, I; Hoover, R; Rodowicz, K; Cripton, P
Ice hockey shoulder pad design and the effect on head response during shoulder-to-head impacts Journal Article
In: Sports Biomechanics, vol. 15, no. 4, pp. 385–396, 2016.
Abstract | BibTeX | Tags: *Craniocerebral Trauma/pc [Prevention & Control], *Head/ph [Physiology], *Hockey/ph [Physiology], *Protective Clothing, *Shoulder/ph [Physiology], Acceleration, Biomechanical Phenomena, Equipment Design, Humans, Male, Manikins, Materials testing, Reproducibility of Results, Risk Factors
@article{Richards2016,
title = {Ice hockey shoulder pad design and the effect on head response during shoulder-to-head impacts},
author = {Richards, D and Ivarsson, B J and Scher, I and Hoover, R and Rodowicz, K and Cripton, P},
year = {2016},
date = {2016-01-01},
journal = {Sports Biomechanics},
volume = {15},
number = {4},
pages = {385--396},
abstract = {Ice hockey body checks involving direct shoulder-to-head contact frequently result in head injury. In the current study, we examined the effect of shoulder pad style on the likelihood of head injury from a shoulder-to-head check. Shoulder-to-head body checks were simulated by swinging a modified Hybrid-III anthropomorphic test device (ATD) with and without shoulder pads into a stationary Hybrid-III ATD at 21 km/h. Tests were conducted with three different styles of shoulder pads (traditional, integrated and tethered) and without shoulder pads for the purpose of control. Head response kinematics for the stationary ATD were measured. Compared to the case of no shoulder pads, the three different pad styles significantly (p \< 0.05) reduced peak resultant linear head accelerations of the stationary ATD by 35-56%. The integrated shoulder pads reduced linear head accelerations by an additional 18-21% beyond the other two styles of shoulder pads. The data presented here suggest that shoulder pads can be designed to help protect the head of the struck player in a shoulder-to-head check.},
keywords = {*Craniocerebral Trauma/pc [Prevention \& Control], *Head/ph [Physiology], *Hockey/ph [Physiology], *Protective Clothing, *Shoulder/ph [Physiology], Acceleration, Biomechanical Phenomena, Equipment Design, Humans, Male, Manikins, Materials testing, Reproducibility of Results, Risk Factors},
pubstate = {published},
tppubtype = {article}
}
Odom, M J; Lee, Y M; Zuckerman, S L; Apple, R P; Germanos, T; Solomon, G S; Sills, A K
Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System Journal Article
In: J Surg Orthop Adv, vol. 25, no. 2, pp. 93–98, 2016.
Abstract | BibTeX | Tags: *Athletic Injuries/di [Diagnosis], *Brain Concussion/di [Diagnosis], *Postural Balance, *Sensation Disorders/di [Diagnosis], adult, Athletic Injuries/co [Complications], Brain Concussion/co [Complications], Computer-Assisted, DIAGNOSIS, Female, Humans, Male, Reproducibility of Results, Sensation Disorders/et [Etiology], Young Adult
@article{Odom2016,
title = {Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System},
author = {Odom, M J and Lee, Y M and Zuckerman, S L and Apple, R P and Germanos, T and Solomon, G S and Sills, A K},
year = {2016},
date = {2016-01-01},
journal = {J Surg Orthop Adv},
volume = {25},
number = {2},
pages = {93--98},
abstract = {This study evaluated the test-retest reliability of a novel computer-based, portable balance assessment tool, the Equilibrate System (ES), used to diagnose sports-related concussion. Twenty-seven students participated in ES testing consisting of three sessions over 4 weeks. The modified Balance Error Scoring System was performed. For each participant, test-retest reliability was established using the intraclass correlation coefficient (ICC). The ES test-retest reliability from baseline to week 2 produced an ICC value of 0.495 (95% CI, 0.123-0.745). Week 2 testing produced ICC values of 0.602 (95% CI, 0.279-0.803) and 0.610 (95% CI, 0.299-0.804), respectively. All other single measures test-retest reliability values produced poor ICC values. Same-day ES testing showed fair to good test-retest reliability while interweek measures displayed poor to fair test-retest reliability. Testing conditions should be controlled when using computerized balance assessment methods. ES testing should only be used as a part of a comprehensive assessment.},
keywords = {*Athletic Injuries/di [Diagnosis], *Brain Concussion/di [Diagnosis], *Postural Balance, *Sensation Disorders/di [Diagnosis], adult, Athletic Injuries/co [Complications], Brain Concussion/co [Complications], Computer-Assisted, DIAGNOSIS, Female, Humans, Male, Reproducibility of Results, Sensation Disorders/et [Etiology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Armistead-Jehle, P; Cooper, D B; Vanderploeg, R D
The role of performance validity tests in the assessment of cognitive functioning after military concussion: A replication and extension Journal Article
In: Applied Neuropsychology. Adult, vol. 23, no. 4, pp. 264–273, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Cognitive Dysfunction/di [Diagnosis], *Military Personnel/px [Psychology], *Neuropsychological Tests/st [Standards], adult, Brain Concussion/px [Psychology], Cognitive Dysfunction/px [Psychology], Female, Humans, Male, Malingering/di [Diagnosis], REGRESSION analysis, Reproducibility of Results, Young Adult
@article{Armistead-Jehle2016,
title = {The role of performance validity tests in the assessment of cognitive functioning after military concussion: A replication and extension},
author = {Armistead-Jehle, P and Cooper, D B and Vanderploeg, R D},
year = {2016},
date = {2016-01-01},
journal = {Applied Neuropsychology. Adult},
volume = {23},
number = {4},
pages = {264--273},
abstract = {The current investigation is a replication and extension of a previously published study by Cooper, Vanderploeg, Armistead-Jehle, Lewis, and Bowles (2014) demonstrating that performance validity test scores accounted for more variance in cognitive testing among service members with a history of concussion than did demographic variables, etiology of and time since injury, and symptom severity. The present study included a sample of 142 active-duty service members evaluated following a suspected or confirmed history of mild traumatic brain injury. Participants completed a battery of neuropsychological measures that included scales of performance and symptom validity (specifically the Medical Symptom Validity Test, Nonverbal Medical Symptom Validity Test, and Personality Assessment Inventory). Among the factors considered in the current study, performance validity test results accounted for the most variance in cognitive test scores, above demographic, concussion history, symptom validity, and psychological distress variables. Performance validity test results were modestly related to symptom validity as measured by the Personality Assessment Inventory Negative Impression Management scale. In sum, the current results replicated the original Cooper et al. study and highlight the importance of including performance validity tests as part of neurocognitive evaluation, even in clinical contexts, within this population.},
keywords = {*Brain Concussion/di [Diagnosis], *Cognitive Dysfunction/di [Diagnosis], *Military Personnel/px [Psychology], *Neuropsychological Tests/st [Standards], adult, Brain Concussion/px [Psychology], Cognitive Dysfunction/px [Psychology], Female, Humans, Male, Malingering/di [Diagnosis], REGRESSION analysis, Reproducibility of Results, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Little, C E; Emery, C; Black, A; Scott, S H; Meeuwisse, W; Nettel-Aguirre, A; Benson, B; Dukelow, S
Test-retest reliability of KINARM robot sensorimotor and cognitive assessment: in pediatric ice hockey players Journal Article
In: Journal of Neuroengineering & Rehabilitation, vol. 12, pp. 78, 2015.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Brain Concussion/px [Psychology], *COGNITION, *Hockey/in [Injuries], *Robotics, *Sensation, Adolescent, Biomechanical Phenomena, Brain Concussion/pp [Physiopathology], Child, Computer simulation, Humans, learning, Longitudinal studies, Male, Neuropsychological Tests, Practice (Psychology), Prognosis, Prospective Studies, Psychomotor Performance/ph [Physiology], Reproducibility of Results, treatment outcome
@article{Little2015,
title = {Test-retest reliability of KINARM robot sensorimotor and cognitive assessment: in pediatric ice hockey players},
author = {Little, C E and Emery, C and Black, A and Scott, S H and Meeuwisse, W and Nettel-Aguirre, A and Benson, B and Dukelow, S},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neuroengineering \& Rehabilitation},
volume = {12},
pages = {78},
abstract = {BACKGROUND: Better diagnostic and prognostic tools are needed to address issues related to early diagnosis and management of concussion across the continuum of aging but particularly in children and adolescents. The purpose of the current study was to evaluate the reliability of robotic technology (KINARM robot) assessments of reaching, position sense, bimanual motor function, visuospatial skills, attention and decision making in youth ice hockey players (ages 10-14). METHODS: Thirty-four male children attended two testing days, one week apart. On day one, each subject completed five tasks on the robot with two examiners (alternating examiner sequence); the 2(nd) examiner followed the same procedure as the 1(st) immediately afterwards. One consistent examiner tested subjects one week later. This is a test-retest reliability study. The robotic tasks characterize sensorimotor and/or cognitive performance; 63 parameters from 5 tasks are reported. Session 1 was the 1(st) time the subject performed the 5 tasks, session 2 the 2(nd) time on day 1, and session 3 one week following. RESULTS: Intra-class correlation coefficients ranged from 0.06 to 0.91 and 0.09 to 0.90 for session 1 to 2 and 2 to 3, respectively. Bland-Altman plots showed agreement in a majority of the parameters and a learning effect in 25 % and 24 % of parameters in session 1 vs 2 and 1 vs 3, respectively but none for session 2 vs 3. Of those that showed a learning effect, only 8 % of parameters in session 1 vs 2 and 10 % in session 1 vs 3 had a clinical relevance measure\>0.8. CONCLUSIONS: The relative homogeneity of the sample and the effect of learning seen in some of the task parameters appears to have negatively impacted the intra-class correlation coefficients from session 1 to 2, with less impact for 2 to 3. The Bland-Altman analysis supports good absolute reliability in healthy male children with no neurological impairment ranging in age from 10 to 14. The clinically relevant learning effect seen, in a small number of parameters could be addressed by creating a learning effect adjustment factor and/or implementing a practice session, which would eliminate the learning effect.},
keywords = {*Brain Concussion/di [Diagnosis], *Brain Concussion/px [Psychology], *COGNITION, *Hockey/in [Injuries], *Robotics, *Sensation, Adolescent, Biomechanical Phenomena, Brain Concussion/pp [Physiopathology], Child, Computer simulation, Humans, learning, Longitudinal studies, Male, Neuropsychological Tests, Practice (Psychology), Prognosis, Prospective Studies, Psychomotor Performance/ph [Physiology], Reproducibility of Results, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
Nelson, L D; Pfaller, A Y; Rein, L E; McCrea, M A
Rates and Predictors of Invalid Baseline Test Performance in High School and Collegiate Athletes for 3 Computerized Neurocognitive Tests: ANAM, Axon Sports, and ImPACT Journal Article
In: American Journal of Sports Medicine, vol. 43, no. 8, pp. 2018–2026, 2015.
Abstract | BibTeX | Tags: *Athletes/px [Psychology], *Neuropsychological Tests, Adolescent, Athletic Injuries/di [Diagnosis], Athletic Injuries/px [Psychology], Attention Deficit Disorder with Hyperactivity/co [, Brain Concussion/di [Diagnosis], Brain Concussion/px [Psychology], Female, Humans, intelligence, Male, Reproducibility of Results, Students/px [Psychology], Young Adult
@article{Nelson2015,
title = {Rates and Predictors of Invalid Baseline Test Performance in High School and Collegiate Athletes for 3 Computerized Neurocognitive Tests: ANAM, Axon Sports, and ImPACT},
author = {Nelson, L D and Pfaller, A Y and Rein, L E and McCrea, M A},
year = {2015},
date = {2015-01-01},
journal = {American Journal of Sports Medicine},
volume = {43},
number = {8},
pages = {2018--2026},
abstract = {BACKGROUND: Preseason baseline testing using computerized neurocognitive tests (CNTs) is increasingly performed on athletes. Adequate effort is critical to establish valid estimates of ability, but many users do not evaluate performance validity, and the conditions that affect validity are not well understood across the available CNTs. PURPOSE: To examine the rates and predictors of invalid baseline performance for 3 popular CNTs: Automated Neuropsychological Assessment Metrics (ANAM), Axon Sports, and Immediate Post-Concussion and Cognitive Testing (ImPACT). STUDY DESIGN: Controlled laboratory study. METHODS: High school and collegiate athletes (N = 2063) completed 2 of 3 CNTs each during preseason evaluations. All possible pairings were present across the sample, and the order of administration was randomized. Examiners provided 1-on-1, scripted pretest instructions, emphasizing the importance of good effort. Profile validity was determined by the manufacturers' standard criteria. RESULTS: The overall percentage of tests flagged as of questionable validity was lowest for ImPACT (2.7%) and higher for ANAM and Axon (10.7% and 11.3%, respectively). The majority of invalid baseline profiles were flagged as such because of failure on only 1 validity criterion. Several athlete and testing factors (eg, attention deficit hyperactivity disorder [ADHD], estimated general intellectual ability, administration order) predicted validity status for 1 or more CNTs. Considering only first CNT administrations and participants without ADHD and/or a learning disability (n = 1835) brought the rates of invalid baseline performances to 2.1%, 8.8%, and 7.0% for ImPACT, ANAM, and Axon, respectively. Invalid profiles on the Medical Symptom Validity Test (MSVT) were rare (1.8% of participants) and demonstrated poor correspondence to CNT validity outcomes. CONCLUSION: The validity criteria for these CNTs may not identify the same causes of invalidity or be equally sensitive to effort. The validity indicators may not be equally appropriate for some athletes (eg, those with neurodevelopmental disorders). CLINICAL RELEVANCE: The data suggest that athletes do not put forth widespread low effort or that some validity criteria are more sensitive to invalid performance than others. It is important for examiners to be aware of the conditions that maximize the quality of baseline assessments and to understand what sources of invalid performance are captured by the validity criteria that they obtain.Copyright © 2015 The Author(s).},
keywords = {*Athletes/px [Psychology], *Neuropsychological Tests, Adolescent, Athletic Injuries/di [Diagnosis], Athletic Injuries/px [Psychology], Attention Deficit Disorder with Hyperactivity/co [, Brain Concussion/di [Diagnosis], Brain Concussion/px [Psychology], Female, Humans, intelligence, Male, Reproducibility of Results, Students/px [Psychology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Bartsch, A; Samorezov, S; Benzel, E; Miele, V; Brett, D
Validation of an "Intelligent Mouthguard" Single Event Head Impact Dosimeter Journal Article
In: Stapp Car Crash Journal, vol. 58, pp. 1–27, 2014.
Abstract | BibTeX | Tags: *Acceleration, *Boxing, *Brain Injuries, *Football, *Mouth Protectors, *Telemetry, ALGORITHMS, Biomechanical Phenomena/ph [Physiology], Boxing/in [Injuries], Boxing/ph [Physiology], Brain Injuries/di [Diagnosis], Brain Injuries/et [Etiology], Brain Injuries/pc [Prevention & Control], Brain Injuries/pp [Physiopathology], finite element analysis, Football/in [Injuries], Football/ph [Physiology], Head Protective Devices, Humans, Reproducibility of Results, Telemetry/is [Instrumentation], Telemetry/mt [Methods]
@article{Bartsch2014,
title = {Validation of an "Intelligent Mouthguard" Single Event Head Impact Dosimeter},
author = {Bartsch, A and Samorezov, S and Benzel, E and Miele, V and Brett, D},
year = {2014},
date = {2014-01-01},
journal = {Stapp Car Crash Journal},
volume = {58},
pages = {1--27},
abstract = {Dating to Colonel John Paul Stapp MD in 1975, scientists have desired to measure live human head impacts with accuracy and precision. But no instrument exists to accurately and precisely quantify single head impact events. Our goal is to develop a practical single event head impact dosimeter known as "Intelligent Mouthguard" and quantify its performance on the benchtop, in vitro and in vivo. In the Intelligent Mouthguard hardware, limited gyroscope bandwidth requires an algorithm-based correction as a function of impact duration. After we apply gyroscope correction algorithm, Intelligent Mouthguard results at time of CG linear acceleration peak correlate to the Reference Hybrid III within our tested range of pulse durations and impact acceleration profiles in American football and Boxing in vitro tests: American football},
keywords = {*Acceleration, *Boxing, *Brain Injuries, *Football, *Mouth Protectors, *Telemetry, ALGORITHMS, Biomechanical Phenomena/ph [Physiology], Boxing/in [Injuries], Boxing/ph [Physiology], Brain Injuries/di [Diagnosis], Brain Injuries/et [Etiology], Brain Injuries/pc [Prevention \& Control], Brain Injuries/pp [Physiopathology], finite element analysis, Football/in [Injuries], Football/ph [Physiology], Head Protective Devices, Humans, Reproducibility of Results, Telemetry/is [Instrumentation], Telemetry/mt [Methods]},
pubstate = {published},
tppubtype = {article}
}
Wu, L C; Zarnescu, L; Nangia, V; Cam, B; Camarillo, D B
A head impact detection system using SVM classification and proximity sensing in an instrumented mouthguard Journal Article
In: IEEE Transactions on Biomedical Engineering, vol. 61, no. 11, pp. 2659–2668, 2014.
Abstract | BibTeX | Tags: *Biomechanical Phenomena/ph [Physiology], *Head/ph [Physiology], *Monitoring, *Mouth Protectors, *Support Vector Machine, Acceleration, Accelerometry/is [Instrumentation], Ambulatory/is [Instrumentation], Ambulatory/mt [Methods], Closed, Computer-Assisted/is [Instrumen, football, Head Injuries, Humans, Infrared Rays, Monitoring, Reproducibility of Results, Sensitivity and Specificity, Signal Processing
@article{Wu2014,
title = {A head impact detection system using SVM classification and proximity sensing in an instrumented mouthguard},
author = {Wu, L C and Zarnescu, L and Nangia, V and Cam, B and Camarillo, D B},
year = {2014},
date = {2014-01-01},
journal = {IEEE Transactions on Biomedical Engineering},
volume = {61},
number = {11},
pages = {2659--2668},
abstract = {Injury from blunt head impacts causes acute neurological deficits and may lead to chronic neurodegeneration. A head impact detection device can serve both as a research tool for studying head injury mechanisms and a clinical tool for real-time trauma screening. The simplest approach is an acceleration thresholding algorithm, which may falsely detect high-acceleration spurious events such as manual manipulation of the device. We designed a head impact detection system that distinguishes head impacts from nonimpacts through two subsystems. First, we use infrared proximity sensing to determine if the mouthguard is worn on the teeth to filter out all off-teeth events. Second, on-teeth, nonimpact events are rejected using a support vector machine classifier trained on frequency domain features of linear acceleration and rotational velocity. The remaining events are classified as head impacts. In a controlled laboratory evaluation, the present system performed substantially better than a 10-g acceleration threshold in head impact detection (98% sensitivity, 99.99% specificity, 99% accuracy, and 99.98% precision, compared to 92% sensitivity, 58% specificity, 65% accuracy, and 37% precision). Once adapted for field deployment by training and validation with field data, this system has the potential to effectively detect head trauma in sports, military service, and other high-risk activities.},
keywords = {*Biomechanical Phenomena/ph [Physiology], *Head/ph [Physiology], *Monitoring, *Mouth Protectors, *Support Vector Machine, Acceleration, Accelerometry/is [Instrumentation], Ambulatory/is [Instrumentation], Ambulatory/mt [Methods], Closed, Computer-Assisted/is [Instrumen, football, Head Injuries, Humans, Infrared Rays, Monitoring, Reproducibility of Results, Sensitivity and Specificity, Signal Processing},
pubstate = {published},
tppubtype = {article}
}
Falconer, E K; Geffen, G M; Olsen, S L; McFarland, K
The rapid screen of concussion: an evaluation of the non-word repetition test for use in mTBI research Journal Article
In: Brain Injury, vol. 20, no. 12, pp. 1251–1263, 2006.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Mass Screening/mt [Methods], *Neuropsychological Tests, Adolescent, adult, Brain Concussion/et [Etiology], Brain Concussion/px [Psychology], Brain Injuries/co [Complications], Brain Injuries/px [Psychology], Female, Humans, Male, Mental Recall, middle aged, Reproducibility of Results, Sensitivity and Specificity, Verbal Learning
@article{Falconer2006,
title = {The rapid screen of concussion: an evaluation of the non-word repetition test for use in mTBI research},
author = {Falconer, E K and Geffen, G M and Olsen, S L and McFarland, K},
year = {2006},
date = {2006-01-01},
journal = {Brain Injury},
volume = {20},
number = {12},
pages = {1251--1263},
abstract = {PRIMARY OBJECTIVES: (1) To investigate the Nonword Repetition test (NWR) as an index of sub-vocal rehearsal deficits after mild traumatic brain injury (mTBI); (2) to assess the reliability, validity and sensitivity of the NWR; and (3) to compare the NWR to more sensitive tests of verbal memory. RESEARCH DESIGN: An independent groups design. METHODS AND PROCEDURES: Study 1 administered the NWR to 46 mTBI and 61 uninjured controls with the Rapid Screen of Concussion (RSC). Study 2 compared mTBI, orthopaedic and uninjured participants on the NWR and the Hopkins Verbal Learning Test (HVLT-R). MAIN OUTCOMES AND RESULTS: The NWR did not improve the diagnostic accuracy of the RSC. However, it is reliable and indexes sub-vocal rehearsal speed. These findings provide evidence that although the current form of the NWR lacks sensitivity to the impact of mTBI, the development of a more sensitive test of sub-vocal rehearsal deficits following mTBI is warranted.},
keywords = {*Brain Concussion/di [Diagnosis], *Mass Screening/mt [Methods], *Neuropsychological Tests, Adolescent, adult, Brain Concussion/et [Etiology], Brain Concussion/px [Psychology], Brain Injuries/co [Complications], Brain Injuries/px [Psychology], Female, Humans, Male, Mental Recall, middle aged, Reproducibility of Results, Sensitivity and Specificity, Verbal Learning},
pubstate = {published},
tppubtype = {article}
}
Chetelat, G; Eustache, F; Viader, F; De La Sayette, V; Pelerin, A; Mezenge, F; Hannequin, D; Dupuy, B; Baron, J C; Desgranges, B
FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment Journal Article
In: Neurocase, vol. 11, no. 1, pp. 14–25, 2005.
Abstract | BibTeX | Tags: *Cognition Disorders/dg [Diagnostic Imaging], *Fluorodeoxyglucose F18, *Neuropsychological Tests, *Positron-Emission Tomography, 0Z5B2CJX4D (Fluorodeoxyglucose F18), 80 and over, aged, ANALYSIS of variance, Brain Concussion/dg [Diagnostic Imaging], Brain Concussion/pa [Pathology], BRAIN mapping, Cognition Disorders/di [Diagnosis], Dementia/dg [Diagnostic Imaging], Dementia/di [Diagnosis], Dementia/pp [Physiopathology], Female, Follow-Up Studies, Humans, Male, Memory/ph [Physiology], Mental Status Schedule, middle aged, Predictive Value of Tests, Regression (Psychology), Reproducibility of Results, Time Factors
@article{Chetelat2005,
title = {FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment},
author = {Chetelat, G and Eustache, F and Viader, F and {De La Sayette}, V and Pelerin, A and Mezenge, F and Hannequin, D and Dupuy, B and Baron, J C and Desgranges, B},
year = {2005},
date = {2005-01-01},
journal = {Neurocase},
volume = {11},
number = {1},
pages = {14--25},
abstract = {The accurate prediction, at a pre-dementia stage of Alzheimer's disease (AD), of the subsequent clinical evolution of patients would be a major breakthrough from both therapeutic and research standpoints. Amnestic mild cognitive impairment (MCI) is presently the most common reference to address the pre-dementia stage of AD. However, previous longitudinal studies on patients with MCI assessing neuropsychological and PET markers of future conversion to AD are sparse and yield discrepant findings, while a comprehensive comparison of the relative accuracy of these two categories of measure is still lacking. In the present study, we assessed the global cognitive decline as measured by the Mattis scale in 18 patients with amnestic MCI over an 18-month follow-up period, studying which subtest of this scale showed significant deterioration over time. Using baseline measurements from neuropsychological evaluation of memory and PET, we then assessed significant markers of global cognitive change, that is, percent annual change in the Mattis scale total score, and searched for the best predictor of this global cognitive decline. Altogether, our results revealed significant decline over the 18-month follow-up period in the total score and the verbal initiation and memory-recall subscores of the Mattis scale. The percent annual change in the total Mattis score significantly correlated with age and baseline performances in delayed episodic memory recall as well as semantic autobiographical and category word fluencies. Regarding functional imaging, significant correlations were also found with baseline PET values in the right temporo-parietal and medial frontal areas. Age and right temporo-parietal PET values were the most significant predictors of subsequent global cognitive decline, and the only ones to survive stepwise regression analyses. Our findings are consistent with previous works showing predominant delayed recall and semantic memory impairment at a pre-dementia stage of AD, as well as early metabolic defects in the temporo-parietal associative cortex. However, they suggest that only the latter predictor is specifically and accurately associated with subsequent cognitive decline in patients with MCI within 18 months of first assessment.},
keywords = {*Cognition Disorders/dg [Diagnostic Imaging], *Fluorodeoxyglucose F18, *Neuropsychological Tests, *Positron-Emission Tomography, 0Z5B2CJX4D (Fluorodeoxyglucose F18), 80 and over, aged, ANALYSIS of variance, Brain Concussion/dg [Diagnostic Imaging], Brain Concussion/pa [Pathology], BRAIN mapping, Cognition Disorders/di [Diagnosis], Dementia/dg [Diagnostic Imaging], Dementia/di [Diagnosis], Dementia/pp [Physiopathology], Female, Follow-Up Studies, Humans, Male, Memory/ph [Physiology], Mental Status Schedule, middle aged, Predictive Value of Tests, Regression (Psychology), Reproducibility of Results, Time Factors},
pubstate = {published},
tppubtype = {article}
}
Hansen, C; Cushman, D; Chen, W; Bounsanga, J; Hung, M
Reliability testing of the balance error scoring system in children between the ages of 5 and 14 Journal Article
In: Clinical Journal of Sport Medicine, vol. 27, no. 1, pp. 64–68, 2017.
@article{Hansen2017,
title = {Reliability testing of the balance error scoring system in children between the ages of 5 and 14},
author = {Hansen, C and Cushman, D and Chen, W and Bounsanga, J and Hung, M},
doi = {10.1097/JSM.0000000000000293},
year = {2017},
date = {2017-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {27},
number = {1},
pages = {64--68},
abstract = {Objective: Pediatric concussion is an extensive public health concern with a complex clinical presentation. Balance assessment has been well-studied in the adult population, but has been limited in children. We aimed to assess the reliability and minimum detectable change (MDC) of the Balance Error Scoring System (BESS) in healthy children. Design: This prospective observational study included 373 healthy children aged 5 to 14. Interrater reliability was assessed by having 4 assessors review videos of 50 random subjects distributed evenly by age and sex across the entire cohort. Intrarater reliability was performed by having assessors review videos of other assessors' live evaluations. Test-retest reliability was obtained by comparing BESS scores as recorded live at the 2 separate time points by the same rater. Setting: Local elementary and junior high schools. Participants: Three hundred and seventy three healthy children between the ages of 5 and 14. Interventions: The BESS was performed on all children. Main Outcome Measures: Intraclass Correlation Coefficients (ICCs) and MDC Scores. Results: The overall interrater ICC was determined to be 0.93 [95% confidence interval (CI), 0.79-0.97] and intrarater ICC was 0.96 (95% CI, 0.95-0.97) with individual intrarater ICCs ranging between 0.69 and 0.99. The test-retest reliability was 0.90 (95% CI, 0.88- 0.92). The MDCs were 9.6, 4.6, and 7.3 points at the 95% CIs for interrater, intrarater, and test-retest comparisons, respectively. No learning effect was seen. Conclusions: The BESS demonstrates excellent reliability in the pediatric population without evidence of a learning effect. © 2016 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Richards, D; Ivarsson, B J; Scher, I; Hoover, R; Rodowicz, K; Cripton, P
Ice hockey shoulder pad design and the effect on head response during shoulder-to-head impacts Journal Article
In: Sports Biomechanics, vol. 15, no. 4, pp. 385–396, 2016.
@article{Richards2016,
title = {Ice hockey shoulder pad design and the effect on head response during shoulder-to-head impacts},
author = {Richards, D and Ivarsson, B J and Scher, I and Hoover, R and Rodowicz, K and Cripton, P},
year = {2016},
date = {2016-01-01},
journal = {Sports Biomechanics},
volume = {15},
number = {4},
pages = {385--396},
abstract = {Ice hockey body checks involving direct shoulder-to-head contact frequently result in head injury. In the current study, we examined the effect of shoulder pad style on the likelihood of head injury from a shoulder-to-head check. Shoulder-to-head body checks were simulated by swinging a modified Hybrid-III anthropomorphic test device (ATD) with and without shoulder pads into a stationary Hybrid-III ATD at 21 km/h. Tests were conducted with three different styles of shoulder pads (traditional, integrated and tethered) and without shoulder pads for the purpose of control. Head response kinematics for the stationary ATD were measured. Compared to the case of no shoulder pads, the three different pad styles significantly (p \< 0.05) reduced peak resultant linear head accelerations of the stationary ATD by 35-56%. The integrated shoulder pads reduced linear head accelerations by an additional 18-21% beyond the other two styles of shoulder pads. The data presented here suggest that shoulder pads can be designed to help protect the head of the struck player in a shoulder-to-head check.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Odom, M J; Lee, Y M; Zuckerman, S L; Apple, R P; Germanos, T; Solomon, G S; Sills, A K
Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System Journal Article
In: J Surg Orthop Adv, vol. 25, no. 2, pp. 93–98, 2016.
@article{Odom2016,
title = {Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System},
author = {Odom, M J and Lee, Y M and Zuckerman, S L and Apple, R P and Germanos, T and Solomon, G S and Sills, A K},
year = {2016},
date = {2016-01-01},
journal = {J Surg Orthop Adv},
volume = {25},
number = {2},
pages = {93--98},
abstract = {This study evaluated the test-retest reliability of a novel computer-based, portable balance assessment tool, the Equilibrate System (ES), used to diagnose sports-related concussion. Twenty-seven students participated in ES testing consisting of three sessions over 4 weeks. The modified Balance Error Scoring System was performed. For each participant, test-retest reliability was established using the intraclass correlation coefficient (ICC). The ES test-retest reliability from baseline to week 2 produced an ICC value of 0.495 (95% CI, 0.123-0.745). Week 2 testing produced ICC values of 0.602 (95% CI, 0.279-0.803) and 0.610 (95% CI, 0.299-0.804), respectively. All other single measures test-retest reliability values produced poor ICC values. Same-day ES testing showed fair to good test-retest reliability while interweek measures displayed poor to fair test-retest reliability. Testing conditions should be controlled when using computerized balance assessment methods. ES testing should only be used as a part of a comprehensive assessment.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Armistead-Jehle, P; Cooper, D B; Vanderploeg, R D
The role of performance validity tests in the assessment of cognitive functioning after military concussion: A replication and extension Journal Article
In: Applied Neuropsychology. Adult, vol. 23, no. 4, pp. 264–273, 2016.
@article{Armistead-Jehle2016,
title = {The role of performance validity tests in the assessment of cognitive functioning after military concussion: A replication and extension},
author = {Armistead-Jehle, P and Cooper, D B and Vanderploeg, R D},
year = {2016},
date = {2016-01-01},
journal = {Applied Neuropsychology. Adult},
volume = {23},
number = {4},
pages = {264--273},
abstract = {The current investigation is a replication and extension of a previously published study by Cooper, Vanderploeg, Armistead-Jehle, Lewis, and Bowles (2014) demonstrating that performance validity test scores accounted for more variance in cognitive testing among service members with a history of concussion than did demographic variables, etiology of and time since injury, and symptom severity. The present study included a sample of 142 active-duty service members evaluated following a suspected or confirmed history of mild traumatic brain injury. Participants completed a battery of neuropsychological measures that included scales of performance and symptom validity (specifically the Medical Symptom Validity Test, Nonverbal Medical Symptom Validity Test, and Personality Assessment Inventory). Among the factors considered in the current study, performance validity test results accounted for the most variance in cognitive test scores, above demographic, concussion history, symptom validity, and psychological distress variables. Performance validity test results were modestly related to symptom validity as measured by the Personality Assessment Inventory Negative Impression Management scale. In sum, the current results replicated the original Cooper et al. study and highlight the importance of including performance validity tests as part of neurocognitive evaluation, even in clinical contexts, within this population.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Little, C E; Emery, C; Black, A; Scott, S H; Meeuwisse, W; Nettel-Aguirre, A; Benson, B; Dukelow, S
Test-retest reliability of KINARM robot sensorimotor and cognitive assessment: in pediatric ice hockey players Journal Article
In: Journal of Neuroengineering & Rehabilitation, vol. 12, pp. 78, 2015.
@article{Little2015,
title = {Test-retest reliability of KINARM robot sensorimotor and cognitive assessment: in pediatric ice hockey players},
author = {Little, C E and Emery, C and Black, A and Scott, S H and Meeuwisse, W and Nettel-Aguirre, A and Benson, B and Dukelow, S},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neuroengineering \& Rehabilitation},
volume = {12},
pages = {78},
abstract = {BACKGROUND: Better diagnostic and prognostic tools are needed to address issues related to early diagnosis and management of concussion across the continuum of aging but particularly in children and adolescents. The purpose of the current study was to evaluate the reliability of robotic technology (KINARM robot) assessments of reaching, position sense, bimanual motor function, visuospatial skills, attention and decision making in youth ice hockey players (ages 10-14). METHODS: Thirty-four male children attended two testing days, one week apart. On day one, each subject completed five tasks on the robot with two examiners (alternating examiner sequence); the 2(nd) examiner followed the same procedure as the 1(st) immediately afterwards. One consistent examiner tested subjects one week later. This is a test-retest reliability study. The robotic tasks characterize sensorimotor and/or cognitive performance; 63 parameters from 5 tasks are reported. Session 1 was the 1(st) time the subject performed the 5 tasks, session 2 the 2(nd) time on day 1, and session 3 one week following. RESULTS: Intra-class correlation coefficients ranged from 0.06 to 0.91 and 0.09 to 0.90 for session 1 to 2 and 2 to 3, respectively. Bland-Altman plots showed agreement in a majority of the parameters and a learning effect in 25 % and 24 % of parameters in session 1 vs 2 and 1 vs 3, respectively but none for session 2 vs 3. Of those that showed a learning effect, only 8 % of parameters in session 1 vs 2 and 10 % in session 1 vs 3 had a clinical relevance measure\>0.8. CONCLUSIONS: The relative homogeneity of the sample and the effect of learning seen in some of the task parameters appears to have negatively impacted the intra-class correlation coefficients from session 1 to 2, with less impact for 2 to 3. The Bland-Altman analysis supports good absolute reliability in healthy male children with no neurological impairment ranging in age from 10 to 14. The clinically relevant learning effect seen, in a small number of parameters could be addressed by creating a learning effect adjustment factor and/or implementing a practice session, which would eliminate the learning effect.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Nelson, L D; Pfaller, A Y; Rein, L E; McCrea, M A
Rates and Predictors of Invalid Baseline Test Performance in High School and Collegiate Athletes for 3 Computerized Neurocognitive Tests: ANAM, Axon Sports, and ImPACT Journal Article
In: American Journal of Sports Medicine, vol. 43, no. 8, pp. 2018–2026, 2015.
@article{Nelson2015,
title = {Rates and Predictors of Invalid Baseline Test Performance in High School and Collegiate Athletes for 3 Computerized Neurocognitive Tests: ANAM, Axon Sports, and ImPACT},
author = {Nelson, L D and Pfaller, A Y and Rein, L E and McCrea, M A},
year = {2015},
date = {2015-01-01},
journal = {American Journal of Sports Medicine},
volume = {43},
number = {8},
pages = {2018--2026},
abstract = {BACKGROUND: Preseason baseline testing using computerized neurocognitive tests (CNTs) is increasingly performed on athletes. Adequate effort is critical to establish valid estimates of ability, but many users do not evaluate performance validity, and the conditions that affect validity are not well understood across the available CNTs. PURPOSE: To examine the rates and predictors of invalid baseline performance for 3 popular CNTs: Automated Neuropsychological Assessment Metrics (ANAM), Axon Sports, and Immediate Post-Concussion and Cognitive Testing (ImPACT). STUDY DESIGN: Controlled laboratory study. METHODS: High school and collegiate athletes (N = 2063) completed 2 of 3 CNTs each during preseason evaluations. All possible pairings were present across the sample, and the order of administration was randomized. Examiners provided 1-on-1, scripted pretest instructions, emphasizing the importance of good effort. Profile validity was determined by the manufacturers' standard criteria. RESULTS: The overall percentage of tests flagged as of questionable validity was lowest for ImPACT (2.7%) and higher for ANAM and Axon (10.7% and 11.3%, respectively). The majority of invalid baseline profiles were flagged as such because of failure on only 1 validity criterion. Several athlete and testing factors (eg, attention deficit hyperactivity disorder [ADHD], estimated general intellectual ability, administration order) predicted validity status for 1 or more CNTs. Considering only first CNT administrations and participants without ADHD and/or a learning disability (n = 1835) brought the rates of invalid baseline performances to 2.1%, 8.8%, and 7.0% for ImPACT, ANAM, and Axon, respectively. Invalid profiles on the Medical Symptom Validity Test (MSVT) were rare (1.8% of participants) and demonstrated poor correspondence to CNT validity outcomes. CONCLUSION: The validity criteria for these CNTs may not identify the same causes of invalidity or be equally sensitive to effort. The validity indicators may not be equally appropriate for some athletes (eg, those with neurodevelopmental disorders). CLINICAL RELEVANCE: The data suggest that athletes do not put forth widespread low effort or that some validity criteria are more sensitive to invalid performance than others. It is important for examiners to be aware of the conditions that maximize the quality of baseline assessments and to understand what sources of invalid performance are captured by the validity criteria that they obtain.Copyright © 2015 The Author(s).},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bartsch, A; Samorezov, S; Benzel, E; Miele, V; Brett, D
Validation of an "Intelligent Mouthguard" Single Event Head Impact Dosimeter Journal Article
In: Stapp Car Crash Journal, vol. 58, pp. 1–27, 2014.
@article{Bartsch2014,
title = {Validation of an "Intelligent Mouthguard" Single Event Head Impact Dosimeter},
author = {Bartsch, A and Samorezov, S and Benzel, E and Miele, V and Brett, D},
year = {2014},
date = {2014-01-01},
journal = {Stapp Car Crash Journal},
volume = {58},
pages = {1--27},
abstract = {Dating to Colonel John Paul Stapp MD in 1975, scientists have desired to measure live human head impacts with accuracy and precision. But no instrument exists to accurately and precisely quantify single head impact events. Our goal is to develop a practical single event head impact dosimeter known as "Intelligent Mouthguard" and quantify its performance on the benchtop, in vitro and in vivo. In the Intelligent Mouthguard hardware, limited gyroscope bandwidth requires an algorithm-based correction as a function of impact duration. After we apply gyroscope correction algorithm, Intelligent Mouthguard results at time of CG linear acceleration peak correlate to the Reference Hybrid III within our tested range of pulse durations and impact acceleration profiles in American football and Boxing in vitro tests: American football},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wu, L C; Zarnescu, L; Nangia, V; Cam, B; Camarillo, D B
A head impact detection system using SVM classification and proximity sensing in an instrumented mouthguard Journal Article
In: IEEE Transactions on Biomedical Engineering, vol. 61, no. 11, pp. 2659–2668, 2014.
@article{Wu2014,
title = {A head impact detection system using SVM classification and proximity sensing in an instrumented mouthguard},
author = {Wu, L C and Zarnescu, L and Nangia, V and Cam, B and Camarillo, D B},
year = {2014},
date = {2014-01-01},
journal = {IEEE Transactions on Biomedical Engineering},
volume = {61},
number = {11},
pages = {2659--2668},
abstract = {Injury from blunt head impacts causes acute neurological deficits and may lead to chronic neurodegeneration. A head impact detection device can serve both as a research tool for studying head injury mechanisms and a clinical tool for real-time trauma screening. The simplest approach is an acceleration thresholding algorithm, which may falsely detect high-acceleration spurious events such as manual manipulation of the device. We designed a head impact detection system that distinguishes head impacts from nonimpacts through two subsystems. First, we use infrared proximity sensing to determine if the mouthguard is worn on the teeth to filter out all off-teeth events. Second, on-teeth, nonimpact events are rejected using a support vector machine classifier trained on frequency domain features of linear acceleration and rotational velocity. The remaining events are classified as head impacts. In a controlled laboratory evaluation, the present system performed substantially better than a 10-g acceleration threshold in head impact detection (98% sensitivity, 99.99% specificity, 99% accuracy, and 99.98% precision, compared to 92% sensitivity, 58% specificity, 65% accuracy, and 37% precision). Once adapted for field deployment by training and validation with field data, this system has the potential to effectively detect head trauma in sports, military service, and other high-risk activities.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Falconer, E K; Geffen, G M; Olsen, S L; McFarland, K
The rapid screen of concussion: an evaluation of the non-word repetition test for use in mTBI research Journal Article
In: Brain Injury, vol. 20, no. 12, pp. 1251–1263, 2006.
@article{Falconer2006,
title = {The rapid screen of concussion: an evaluation of the non-word repetition test for use in mTBI research},
author = {Falconer, E K and Geffen, G M and Olsen, S L and McFarland, K},
year = {2006},
date = {2006-01-01},
journal = {Brain Injury},
volume = {20},
number = {12},
pages = {1251--1263},
abstract = {PRIMARY OBJECTIVES: (1) To investigate the Nonword Repetition test (NWR) as an index of sub-vocal rehearsal deficits after mild traumatic brain injury (mTBI); (2) to assess the reliability, validity and sensitivity of the NWR; and (3) to compare the NWR to more sensitive tests of verbal memory. RESEARCH DESIGN: An independent groups design. METHODS AND PROCEDURES: Study 1 administered the NWR to 46 mTBI and 61 uninjured controls with the Rapid Screen of Concussion (RSC). Study 2 compared mTBI, orthopaedic and uninjured participants on the NWR and the Hopkins Verbal Learning Test (HVLT-R). MAIN OUTCOMES AND RESULTS: The NWR did not improve the diagnostic accuracy of the RSC. However, it is reliable and indexes sub-vocal rehearsal speed. These findings provide evidence that although the current form of the NWR lacks sensitivity to the impact of mTBI, the development of a more sensitive test of sub-vocal rehearsal deficits following mTBI is warranted.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Chetelat, G; Eustache, F; Viader, F; De La Sayette, V; Pelerin, A; Mezenge, F; Hannequin, D; Dupuy, B; Baron, J C; Desgranges, B
FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment Journal Article
In: Neurocase, vol. 11, no. 1, pp. 14–25, 2005.
@article{Chetelat2005,
title = {FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment},
author = {Chetelat, G and Eustache, F and Viader, F and {De La Sayette}, V and Pelerin, A and Mezenge, F and Hannequin, D and Dupuy, B and Baron, J C and Desgranges, B},
year = {2005},
date = {2005-01-01},
journal = {Neurocase},
volume = {11},
number = {1},
pages = {14--25},
abstract = {The accurate prediction, at a pre-dementia stage of Alzheimer's disease (AD), of the subsequent clinical evolution of patients would be a major breakthrough from both therapeutic and research standpoints. Amnestic mild cognitive impairment (MCI) is presently the most common reference to address the pre-dementia stage of AD. However, previous longitudinal studies on patients with MCI assessing neuropsychological and PET markers of future conversion to AD are sparse and yield discrepant findings, while a comprehensive comparison of the relative accuracy of these two categories of measure is still lacking. In the present study, we assessed the global cognitive decline as measured by the Mattis scale in 18 patients with amnestic MCI over an 18-month follow-up period, studying which subtest of this scale showed significant deterioration over time. Using baseline measurements from neuropsychological evaluation of memory and PET, we then assessed significant markers of global cognitive change, that is, percent annual change in the Mattis scale total score, and searched for the best predictor of this global cognitive decline. Altogether, our results revealed significant decline over the 18-month follow-up period in the total score and the verbal initiation and memory-recall subscores of the Mattis scale. The percent annual change in the total Mattis score significantly correlated with age and baseline performances in delayed episodic memory recall as well as semantic autobiographical and category word fluencies. Regarding functional imaging, significant correlations were also found with baseline PET values in the right temporo-parietal and medial frontal areas. Age and right temporo-parietal PET values were the most significant predictors of subsequent global cognitive decline, and the only ones to survive stepwise regression analyses. Our findings are consistent with previous works showing predominant delayed recall and semantic memory impairment at a pre-dementia stage of AD, as well as early metabolic defects in the temporo-parietal associative cortex. However, they suggest that only the latter predictor is specifically and accurately associated with subsequent cognitive decline in patients with MCI within 18 months of first assessment.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Hansen, C; Cushman, D; Chen, W; Bounsanga, J; Hung, M
Reliability testing of the balance error scoring system in children between the ages of 5 and 14 Journal Article
In: Clinical Journal of Sport Medicine, vol. 27, no. 1, pp. 64–68, 2017.
Abstract | Links | BibTeX | Tags: brain concussion, Child, pediatrics, Reproducibility of Results, Sports
@article{Hansen2017,
title = {Reliability testing of the balance error scoring system in children between the ages of 5 and 14},
author = {Hansen, C and Cushman, D and Chen, W and Bounsanga, J and Hung, M},
doi = {10.1097/JSM.0000000000000293},
year = {2017},
date = {2017-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {27},
number = {1},
pages = {64--68},
abstract = {Objective: Pediatric concussion is an extensive public health concern with a complex clinical presentation. Balance assessment has been well-studied in the adult population, but has been limited in children. We aimed to assess the reliability and minimum detectable change (MDC) of the Balance Error Scoring System (BESS) in healthy children. Design: This prospective observational study included 373 healthy children aged 5 to 14. Interrater reliability was assessed by having 4 assessors review videos of 50 random subjects distributed evenly by age and sex across the entire cohort. Intrarater reliability was performed by having assessors review videos of other assessors' live evaluations. Test-retest reliability was obtained by comparing BESS scores as recorded live at the 2 separate time points by the same rater. Setting: Local elementary and junior high schools. Participants: Three hundred and seventy three healthy children between the ages of 5 and 14. Interventions: The BESS was performed on all children. Main Outcome Measures: Intraclass Correlation Coefficients (ICCs) and MDC Scores. Results: The overall interrater ICC was determined to be 0.93 [95% confidence interval (CI), 0.79-0.97] and intrarater ICC was 0.96 (95% CI, 0.95-0.97) with individual intrarater ICCs ranging between 0.69 and 0.99. The test-retest reliability was 0.90 (95% CI, 0.88- 0.92). The MDCs were 9.6, 4.6, and 7.3 points at the 95% CIs for interrater, intrarater, and test-retest comparisons, respectively. No learning effect was seen. Conclusions: The BESS demonstrates excellent reliability in the pediatric population without evidence of a learning effect. © 2016 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {brain concussion, Child, pediatrics, Reproducibility of Results, Sports},
pubstate = {published},
tppubtype = {article}
}
Richards, D; Ivarsson, B J; Scher, I; Hoover, R; Rodowicz, K; Cripton, P
Ice hockey shoulder pad design and the effect on head response during shoulder-to-head impacts Journal Article
In: Sports Biomechanics, vol. 15, no. 4, pp. 385–396, 2016.
Abstract | BibTeX | Tags: *Craniocerebral Trauma/pc [Prevention & Control], *Head/ph [Physiology], *Hockey/ph [Physiology], *Protective Clothing, *Shoulder/ph [Physiology], Acceleration, Biomechanical Phenomena, Equipment Design, Humans, Male, Manikins, Materials testing, Reproducibility of Results, Risk Factors
@article{Richards2016,
title = {Ice hockey shoulder pad design and the effect on head response during shoulder-to-head impacts},
author = {Richards, D and Ivarsson, B J and Scher, I and Hoover, R and Rodowicz, K and Cripton, P},
year = {2016},
date = {2016-01-01},
journal = {Sports Biomechanics},
volume = {15},
number = {4},
pages = {385--396},
abstract = {Ice hockey body checks involving direct shoulder-to-head contact frequently result in head injury. In the current study, we examined the effect of shoulder pad style on the likelihood of head injury from a shoulder-to-head check. Shoulder-to-head body checks were simulated by swinging a modified Hybrid-III anthropomorphic test device (ATD) with and without shoulder pads into a stationary Hybrid-III ATD at 21 km/h. Tests were conducted with three different styles of shoulder pads (traditional, integrated and tethered) and without shoulder pads for the purpose of control. Head response kinematics for the stationary ATD were measured. Compared to the case of no shoulder pads, the three different pad styles significantly (p \< 0.05) reduced peak resultant linear head accelerations of the stationary ATD by 35-56%. The integrated shoulder pads reduced linear head accelerations by an additional 18-21% beyond the other two styles of shoulder pads. The data presented here suggest that shoulder pads can be designed to help protect the head of the struck player in a shoulder-to-head check.},
keywords = {*Craniocerebral Trauma/pc [Prevention \& Control], *Head/ph [Physiology], *Hockey/ph [Physiology], *Protective Clothing, *Shoulder/ph [Physiology], Acceleration, Biomechanical Phenomena, Equipment Design, Humans, Male, Manikins, Materials testing, Reproducibility of Results, Risk Factors},
pubstate = {published},
tppubtype = {article}
}
Odom, M J; Lee, Y M; Zuckerman, S L; Apple, R P; Germanos, T; Solomon, G S; Sills, A K
Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System Journal Article
In: J Surg Orthop Adv, vol. 25, no. 2, pp. 93–98, 2016.
Abstract | BibTeX | Tags: *Athletic Injuries/di [Diagnosis], *Brain Concussion/di [Diagnosis], *Postural Balance, *Sensation Disorders/di [Diagnosis], adult, Athletic Injuries/co [Complications], Brain Concussion/co [Complications], Computer-Assisted, DIAGNOSIS, Female, Humans, Male, Reproducibility of Results, Sensation Disorders/et [Etiology], Young Adult
@article{Odom2016,
title = {Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System},
author = {Odom, M J and Lee, Y M and Zuckerman, S L and Apple, R P and Germanos, T and Solomon, G S and Sills, A K},
year = {2016},
date = {2016-01-01},
journal = {J Surg Orthop Adv},
volume = {25},
number = {2},
pages = {93--98},
abstract = {This study evaluated the test-retest reliability of a novel computer-based, portable balance assessment tool, the Equilibrate System (ES), used to diagnose sports-related concussion. Twenty-seven students participated in ES testing consisting of three sessions over 4 weeks. The modified Balance Error Scoring System was performed. For each participant, test-retest reliability was established using the intraclass correlation coefficient (ICC). The ES test-retest reliability from baseline to week 2 produced an ICC value of 0.495 (95% CI, 0.123-0.745). Week 2 testing produced ICC values of 0.602 (95% CI, 0.279-0.803) and 0.610 (95% CI, 0.299-0.804), respectively. All other single measures test-retest reliability values produced poor ICC values. Same-day ES testing showed fair to good test-retest reliability while interweek measures displayed poor to fair test-retest reliability. Testing conditions should be controlled when using computerized balance assessment methods. ES testing should only be used as a part of a comprehensive assessment.},
keywords = {*Athletic Injuries/di [Diagnosis], *Brain Concussion/di [Diagnosis], *Postural Balance, *Sensation Disorders/di [Diagnosis], adult, Athletic Injuries/co [Complications], Brain Concussion/co [Complications], Computer-Assisted, DIAGNOSIS, Female, Humans, Male, Reproducibility of Results, Sensation Disorders/et [Etiology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Armistead-Jehle, P; Cooper, D B; Vanderploeg, R D
The role of performance validity tests in the assessment of cognitive functioning after military concussion: A replication and extension Journal Article
In: Applied Neuropsychology. Adult, vol. 23, no. 4, pp. 264–273, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Cognitive Dysfunction/di [Diagnosis], *Military Personnel/px [Psychology], *Neuropsychological Tests/st [Standards], adult, Brain Concussion/px [Psychology], Cognitive Dysfunction/px [Psychology], Female, Humans, Male, Malingering/di [Diagnosis], REGRESSION analysis, Reproducibility of Results, Young Adult
@article{Armistead-Jehle2016,
title = {The role of performance validity tests in the assessment of cognitive functioning after military concussion: A replication and extension},
author = {Armistead-Jehle, P and Cooper, D B and Vanderploeg, R D},
year = {2016},
date = {2016-01-01},
journal = {Applied Neuropsychology. Adult},
volume = {23},
number = {4},
pages = {264--273},
abstract = {The current investigation is a replication and extension of a previously published study by Cooper, Vanderploeg, Armistead-Jehle, Lewis, and Bowles (2014) demonstrating that performance validity test scores accounted for more variance in cognitive testing among service members with a history of concussion than did demographic variables, etiology of and time since injury, and symptom severity. The present study included a sample of 142 active-duty service members evaluated following a suspected or confirmed history of mild traumatic brain injury. Participants completed a battery of neuropsychological measures that included scales of performance and symptom validity (specifically the Medical Symptom Validity Test, Nonverbal Medical Symptom Validity Test, and Personality Assessment Inventory). Among the factors considered in the current study, performance validity test results accounted for the most variance in cognitive test scores, above demographic, concussion history, symptom validity, and psychological distress variables. Performance validity test results were modestly related to symptom validity as measured by the Personality Assessment Inventory Negative Impression Management scale. In sum, the current results replicated the original Cooper et al. study and highlight the importance of including performance validity tests as part of neurocognitive evaluation, even in clinical contexts, within this population.},
keywords = {*Brain Concussion/di [Diagnosis], *Cognitive Dysfunction/di [Diagnosis], *Military Personnel/px [Psychology], *Neuropsychological Tests/st [Standards], adult, Brain Concussion/px [Psychology], Cognitive Dysfunction/px [Psychology], Female, Humans, Male, Malingering/di [Diagnosis], REGRESSION analysis, Reproducibility of Results, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Little, C E; Emery, C; Black, A; Scott, S H; Meeuwisse, W; Nettel-Aguirre, A; Benson, B; Dukelow, S
Test-retest reliability of KINARM robot sensorimotor and cognitive assessment: in pediatric ice hockey players Journal Article
In: Journal of Neuroengineering & Rehabilitation, vol. 12, pp. 78, 2015.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Brain Concussion/px [Psychology], *COGNITION, *Hockey/in [Injuries], *Robotics, *Sensation, Adolescent, Biomechanical Phenomena, Brain Concussion/pp [Physiopathology], Child, Computer simulation, Humans, learning, Longitudinal studies, Male, Neuropsychological Tests, Practice (Psychology), Prognosis, Prospective Studies, Psychomotor Performance/ph [Physiology], Reproducibility of Results, treatment outcome
@article{Little2015,
title = {Test-retest reliability of KINARM robot sensorimotor and cognitive assessment: in pediatric ice hockey players},
author = {Little, C E and Emery, C and Black, A and Scott, S H and Meeuwisse, W and Nettel-Aguirre, A and Benson, B and Dukelow, S},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neuroengineering \& Rehabilitation},
volume = {12},
pages = {78},
abstract = {BACKGROUND: Better diagnostic and prognostic tools are needed to address issues related to early diagnosis and management of concussion across the continuum of aging but particularly in children and adolescents. The purpose of the current study was to evaluate the reliability of robotic technology (KINARM robot) assessments of reaching, position sense, bimanual motor function, visuospatial skills, attention and decision making in youth ice hockey players (ages 10-14). METHODS: Thirty-four male children attended two testing days, one week apart. On day one, each subject completed five tasks on the robot with two examiners (alternating examiner sequence); the 2(nd) examiner followed the same procedure as the 1(st) immediately afterwards. One consistent examiner tested subjects one week later. This is a test-retest reliability study. The robotic tasks characterize sensorimotor and/or cognitive performance; 63 parameters from 5 tasks are reported. Session 1 was the 1(st) time the subject performed the 5 tasks, session 2 the 2(nd) time on day 1, and session 3 one week following. RESULTS: Intra-class correlation coefficients ranged from 0.06 to 0.91 and 0.09 to 0.90 for session 1 to 2 and 2 to 3, respectively. Bland-Altman plots showed agreement in a majority of the parameters and a learning effect in 25 % and 24 % of parameters in session 1 vs 2 and 1 vs 3, respectively but none for session 2 vs 3. Of those that showed a learning effect, only 8 % of parameters in session 1 vs 2 and 10 % in session 1 vs 3 had a clinical relevance measure\>0.8. CONCLUSIONS: The relative homogeneity of the sample and the effect of learning seen in some of the task parameters appears to have negatively impacted the intra-class correlation coefficients from session 1 to 2, with less impact for 2 to 3. The Bland-Altman analysis supports good absolute reliability in healthy male children with no neurological impairment ranging in age from 10 to 14. The clinically relevant learning effect seen, in a small number of parameters could be addressed by creating a learning effect adjustment factor and/or implementing a practice session, which would eliminate the learning effect.},
keywords = {*Brain Concussion/di [Diagnosis], *Brain Concussion/px [Psychology], *COGNITION, *Hockey/in [Injuries], *Robotics, *Sensation, Adolescent, Biomechanical Phenomena, Brain Concussion/pp [Physiopathology], Child, Computer simulation, Humans, learning, Longitudinal studies, Male, Neuropsychological Tests, Practice (Psychology), Prognosis, Prospective Studies, Psychomotor Performance/ph [Physiology], Reproducibility of Results, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
Nelson, L D; Pfaller, A Y; Rein, L E; McCrea, M A
Rates and Predictors of Invalid Baseline Test Performance in High School and Collegiate Athletes for 3 Computerized Neurocognitive Tests: ANAM, Axon Sports, and ImPACT Journal Article
In: American Journal of Sports Medicine, vol. 43, no. 8, pp. 2018–2026, 2015.
Abstract | BibTeX | Tags: *Athletes/px [Psychology], *Neuropsychological Tests, Adolescent, Athletic Injuries/di [Diagnosis], Athletic Injuries/px [Psychology], Attention Deficit Disorder with Hyperactivity/co [, Brain Concussion/di [Diagnosis], Brain Concussion/px [Psychology], Female, Humans, intelligence, Male, Reproducibility of Results, Students/px [Psychology], Young Adult
@article{Nelson2015,
title = {Rates and Predictors of Invalid Baseline Test Performance in High School and Collegiate Athletes for 3 Computerized Neurocognitive Tests: ANAM, Axon Sports, and ImPACT},
author = {Nelson, L D and Pfaller, A Y and Rein, L E and McCrea, M A},
year = {2015},
date = {2015-01-01},
journal = {American Journal of Sports Medicine},
volume = {43},
number = {8},
pages = {2018--2026},
abstract = {BACKGROUND: Preseason baseline testing using computerized neurocognitive tests (CNTs) is increasingly performed on athletes. Adequate effort is critical to establish valid estimates of ability, but many users do not evaluate performance validity, and the conditions that affect validity are not well understood across the available CNTs. PURPOSE: To examine the rates and predictors of invalid baseline performance for 3 popular CNTs: Automated Neuropsychological Assessment Metrics (ANAM), Axon Sports, and Immediate Post-Concussion and Cognitive Testing (ImPACT). STUDY DESIGN: Controlled laboratory study. METHODS: High school and collegiate athletes (N = 2063) completed 2 of 3 CNTs each during preseason evaluations. All possible pairings were present across the sample, and the order of administration was randomized. Examiners provided 1-on-1, scripted pretest instructions, emphasizing the importance of good effort. Profile validity was determined by the manufacturers' standard criteria. RESULTS: The overall percentage of tests flagged as of questionable validity was lowest for ImPACT (2.7%) and higher for ANAM and Axon (10.7% and 11.3%, respectively). The majority of invalid baseline profiles were flagged as such because of failure on only 1 validity criterion. Several athlete and testing factors (eg, attention deficit hyperactivity disorder [ADHD], estimated general intellectual ability, administration order) predicted validity status for 1 or more CNTs. Considering only first CNT administrations and participants without ADHD and/or a learning disability (n = 1835) brought the rates of invalid baseline performances to 2.1%, 8.8%, and 7.0% for ImPACT, ANAM, and Axon, respectively. Invalid profiles on the Medical Symptom Validity Test (MSVT) were rare (1.8% of participants) and demonstrated poor correspondence to CNT validity outcomes. CONCLUSION: The validity criteria for these CNTs may not identify the same causes of invalidity or be equally sensitive to effort. The validity indicators may not be equally appropriate for some athletes (eg, those with neurodevelopmental disorders). CLINICAL RELEVANCE: The data suggest that athletes do not put forth widespread low effort or that some validity criteria are more sensitive to invalid performance than others. It is important for examiners to be aware of the conditions that maximize the quality of baseline assessments and to understand what sources of invalid performance are captured by the validity criteria that they obtain.Copyright © 2015 The Author(s).},
keywords = {*Athletes/px [Psychology], *Neuropsychological Tests, Adolescent, Athletic Injuries/di [Diagnosis], Athletic Injuries/px [Psychology], Attention Deficit Disorder with Hyperactivity/co [, Brain Concussion/di [Diagnosis], Brain Concussion/px [Psychology], Female, Humans, intelligence, Male, Reproducibility of Results, Students/px [Psychology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Bartsch, A; Samorezov, S; Benzel, E; Miele, V; Brett, D
Validation of an "Intelligent Mouthguard" Single Event Head Impact Dosimeter Journal Article
In: Stapp Car Crash Journal, vol. 58, pp. 1–27, 2014.
Abstract | BibTeX | Tags: *Acceleration, *Boxing, *Brain Injuries, *Football, *Mouth Protectors, *Telemetry, ALGORITHMS, Biomechanical Phenomena/ph [Physiology], Boxing/in [Injuries], Boxing/ph [Physiology], Brain Injuries/di [Diagnosis], Brain Injuries/et [Etiology], Brain Injuries/pc [Prevention & Control], Brain Injuries/pp [Physiopathology], finite element analysis, Football/in [Injuries], Football/ph [Physiology], Head Protective Devices, Humans, Reproducibility of Results, Telemetry/is [Instrumentation], Telemetry/mt [Methods]
@article{Bartsch2014,
title = {Validation of an "Intelligent Mouthguard" Single Event Head Impact Dosimeter},
author = {Bartsch, A and Samorezov, S and Benzel, E and Miele, V and Brett, D},
year = {2014},
date = {2014-01-01},
journal = {Stapp Car Crash Journal},
volume = {58},
pages = {1--27},
abstract = {Dating to Colonel John Paul Stapp MD in 1975, scientists have desired to measure live human head impacts with accuracy and precision. But no instrument exists to accurately and precisely quantify single head impact events. Our goal is to develop a practical single event head impact dosimeter known as "Intelligent Mouthguard" and quantify its performance on the benchtop, in vitro and in vivo. In the Intelligent Mouthguard hardware, limited gyroscope bandwidth requires an algorithm-based correction as a function of impact duration. After we apply gyroscope correction algorithm, Intelligent Mouthguard results at time of CG linear acceleration peak correlate to the Reference Hybrid III within our tested range of pulse durations and impact acceleration profiles in American football and Boxing in vitro tests: American football},
keywords = {*Acceleration, *Boxing, *Brain Injuries, *Football, *Mouth Protectors, *Telemetry, ALGORITHMS, Biomechanical Phenomena/ph [Physiology], Boxing/in [Injuries], Boxing/ph [Physiology], Brain Injuries/di [Diagnosis], Brain Injuries/et [Etiology], Brain Injuries/pc [Prevention \& Control], Brain Injuries/pp [Physiopathology], finite element analysis, Football/in [Injuries], Football/ph [Physiology], Head Protective Devices, Humans, Reproducibility of Results, Telemetry/is [Instrumentation], Telemetry/mt [Methods]},
pubstate = {published},
tppubtype = {article}
}
Wu, L C; Zarnescu, L; Nangia, V; Cam, B; Camarillo, D B
A head impact detection system using SVM classification and proximity sensing in an instrumented mouthguard Journal Article
In: IEEE Transactions on Biomedical Engineering, vol. 61, no. 11, pp. 2659–2668, 2014.
Abstract | BibTeX | Tags: *Biomechanical Phenomena/ph [Physiology], *Head/ph [Physiology], *Monitoring, *Mouth Protectors, *Support Vector Machine, Acceleration, Accelerometry/is [Instrumentation], Ambulatory/is [Instrumentation], Ambulatory/mt [Methods], Closed, Computer-Assisted/is [Instrumen, football, Head Injuries, Humans, Infrared Rays, Monitoring, Reproducibility of Results, Sensitivity and Specificity, Signal Processing
@article{Wu2014,
title = {A head impact detection system using SVM classification and proximity sensing in an instrumented mouthguard},
author = {Wu, L C and Zarnescu, L and Nangia, V and Cam, B and Camarillo, D B},
year = {2014},
date = {2014-01-01},
journal = {IEEE Transactions on Biomedical Engineering},
volume = {61},
number = {11},
pages = {2659--2668},
abstract = {Injury from blunt head impacts causes acute neurological deficits and may lead to chronic neurodegeneration. A head impact detection device can serve both as a research tool for studying head injury mechanisms and a clinical tool for real-time trauma screening. The simplest approach is an acceleration thresholding algorithm, which may falsely detect high-acceleration spurious events such as manual manipulation of the device. We designed a head impact detection system that distinguishes head impacts from nonimpacts through two subsystems. First, we use infrared proximity sensing to determine if the mouthguard is worn on the teeth to filter out all off-teeth events. Second, on-teeth, nonimpact events are rejected using a support vector machine classifier trained on frequency domain features of linear acceleration and rotational velocity. The remaining events are classified as head impacts. In a controlled laboratory evaluation, the present system performed substantially better than a 10-g acceleration threshold in head impact detection (98% sensitivity, 99.99% specificity, 99% accuracy, and 99.98% precision, compared to 92% sensitivity, 58% specificity, 65% accuracy, and 37% precision). Once adapted for field deployment by training and validation with field data, this system has the potential to effectively detect head trauma in sports, military service, and other high-risk activities.},
keywords = {*Biomechanical Phenomena/ph [Physiology], *Head/ph [Physiology], *Monitoring, *Mouth Protectors, *Support Vector Machine, Acceleration, Accelerometry/is [Instrumentation], Ambulatory/is [Instrumentation], Ambulatory/mt [Methods], Closed, Computer-Assisted/is [Instrumen, football, Head Injuries, Humans, Infrared Rays, Monitoring, Reproducibility of Results, Sensitivity and Specificity, Signal Processing},
pubstate = {published},
tppubtype = {article}
}
Falconer, E K; Geffen, G M; Olsen, S L; McFarland, K
The rapid screen of concussion: an evaluation of the non-word repetition test for use in mTBI research Journal Article
In: Brain Injury, vol. 20, no. 12, pp. 1251–1263, 2006.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Mass Screening/mt [Methods], *Neuropsychological Tests, Adolescent, adult, Brain Concussion/et [Etiology], Brain Concussion/px [Psychology], Brain Injuries/co [Complications], Brain Injuries/px [Psychology], Female, Humans, Male, Mental Recall, middle aged, Reproducibility of Results, Sensitivity and Specificity, Verbal Learning
@article{Falconer2006,
title = {The rapid screen of concussion: an evaluation of the non-word repetition test for use in mTBI research},
author = {Falconer, E K and Geffen, G M and Olsen, S L and McFarland, K},
year = {2006},
date = {2006-01-01},
journal = {Brain Injury},
volume = {20},
number = {12},
pages = {1251--1263},
abstract = {PRIMARY OBJECTIVES: (1) To investigate the Nonword Repetition test (NWR) as an index of sub-vocal rehearsal deficits after mild traumatic brain injury (mTBI); (2) to assess the reliability, validity and sensitivity of the NWR; and (3) to compare the NWR to more sensitive tests of verbal memory. RESEARCH DESIGN: An independent groups design. METHODS AND PROCEDURES: Study 1 administered the NWR to 46 mTBI and 61 uninjured controls with the Rapid Screen of Concussion (RSC). Study 2 compared mTBI, orthopaedic and uninjured participants on the NWR and the Hopkins Verbal Learning Test (HVLT-R). MAIN OUTCOMES AND RESULTS: The NWR did not improve the diagnostic accuracy of the RSC. However, it is reliable and indexes sub-vocal rehearsal speed. These findings provide evidence that although the current form of the NWR lacks sensitivity to the impact of mTBI, the development of a more sensitive test of sub-vocal rehearsal deficits following mTBI is warranted.},
keywords = {*Brain Concussion/di [Diagnosis], *Mass Screening/mt [Methods], *Neuropsychological Tests, Adolescent, adult, Brain Concussion/et [Etiology], Brain Concussion/px [Psychology], Brain Injuries/co [Complications], Brain Injuries/px [Psychology], Female, Humans, Male, Mental Recall, middle aged, Reproducibility of Results, Sensitivity and Specificity, Verbal Learning},
pubstate = {published},
tppubtype = {article}
}
Chetelat, G; Eustache, F; Viader, F; De La Sayette, V; Pelerin, A; Mezenge, F; Hannequin, D; Dupuy, B; Baron, J C; Desgranges, B
FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment Journal Article
In: Neurocase, vol. 11, no. 1, pp. 14–25, 2005.
Abstract | BibTeX | Tags: *Cognition Disorders/dg [Diagnostic Imaging], *Fluorodeoxyglucose F18, *Neuropsychological Tests, *Positron-Emission Tomography, 0Z5B2CJX4D (Fluorodeoxyglucose F18), 80 and over, aged, ANALYSIS of variance, Brain Concussion/dg [Diagnostic Imaging], Brain Concussion/pa [Pathology], BRAIN mapping, Cognition Disorders/di [Diagnosis], Dementia/dg [Diagnostic Imaging], Dementia/di [Diagnosis], Dementia/pp [Physiopathology], Female, Follow-Up Studies, Humans, Male, Memory/ph [Physiology], Mental Status Schedule, middle aged, Predictive Value of Tests, Regression (Psychology), Reproducibility of Results, Time Factors
@article{Chetelat2005,
title = {FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment},
author = {Chetelat, G and Eustache, F and Viader, F and {De La Sayette}, V and Pelerin, A and Mezenge, F and Hannequin, D and Dupuy, B and Baron, J C and Desgranges, B},
year = {2005},
date = {2005-01-01},
journal = {Neurocase},
volume = {11},
number = {1},
pages = {14--25},
abstract = {The accurate prediction, at a pre-dementia stage of Alzheimer's disease (AD), of the subsequent clinical evolution of patients would be a major breakthrough from both therapeutic and research standpoints. Amnestic mild cognitive impairment (MCI) is presently the most common reference to address the pre-dementia stage of AD. However, previous longitudinal studies on patients with MCI assessing neuropsychological and PET markers of future conversion to AD are sparse and yield discrepant findings, while a comprehensive comparison of the relative accuracy of these two categories of measure is still lacking. In the present study, we assessed the global cognitive decline as measured by the Mattis scale in 18 patients with amnestic MCI over an 18-month follow-up period, studying which subtest of this scale showed significant deterioration over time. Using baseline measurements from neuropsychological evaluation of memory and PET, we then assessed significant markers of global cognitive change, that is, percent annual change in the Mattis scale total score, and searched for the best predictor of this global cognitive decline. Altogether, our results revealed significant decline over the 18-month follow-up period in the total score and the verbal initiation and memory-recall subscores of the Mattis scale. The percent annual change in the total Mattis score significantly correlated with age and baseline performances in delayed episodic memory recall as well as semantic autobiographical and category word fluencies. Regarding functional imaging, significant correlations were also found with baseline PET values in the right temporo-parietal and medial frontal areas. Age and right temporo-parietal PET values were the most significant predictors of subsequent global cognitive decline, and the only ones to survive stepwise regression analyses. Our findings are consistent with previous works showing predominant delayed recall and semantic memory impairment at a pre-dementia stage of AD, as well as early metabolic defects in the temporo-parietal associative cortex. However, they suggest that only the latter predictor is specifically and accurately associated with subsequent cognitive decline in patients with MCI within 18 months of first assessment.},
keywords = {*Cognition Disorders/dg [Diagnostic Imaging], *Fluorodeoxyglucose F18, *Neuropsychological Tests, *Positron-Emission Tomography, 0Z5B2CJX4D (Fluorodeoxyglucose F18), 80 and over, aged, ANALYSIS of variance, Brain Concussion/dg [Diagnostic Imaging], Brain Concussion/pa [Pathology], BRAIN mapping, Cognition Disorders/di [Diagnosis], Dementia/dg [Diagnostic Imaging], Dementia/di [Diagnosis], Dementia/pp [Physiopathology], Female, Follow-Up Studies, Humans, Male, Memory/ph [Physiology], Mental Status Schedule, middle aged, Predictive Value of Tests, Regression (Psychology), Reproducibility of Results, Time Factors},
pubstate = {published},
tppubtype = {article}
}