Auerbach, P S; Waggoner 2nd, W H
It's Time to Change the Rules Journal Article
In: JAMA, vol. 316, no. 12, pp. 1260–1261, 2016.
BibTeX | Tags: *Brain Concussion/co [Complications], *Football/in [Injuries], adult, Brain Concussion/et [Etiology], Brain Concussion/pc [Prevention & Control], Football/st [Standards], Humans, Male, Safety/st [Standards], UNITED States
@article{Auerbach2016,
title = {It's Time to Change the Rules},
author = {Auerbach, P S and {Waggoner 2nd}, W H},
year = {2016},
date = {2016-01-01},
journal = {JAMA},
volume = {316},
number = {12},
pages = {1260--1261},
keywords = {*Brain Concussion/co [Complications], *Football/in [Injuries], adult, Brain Concussion/et [Etiology], Brain Concussion/pc [Prevention \& Control], Football/st [Standards], Humans, Male, Safety/st [Standards], UNITED States},
pubstate = {published},
tppubtype = {article}
}
Steiger, B
Meet Bennet Omalu, Md: The Physician Leader Whose Research Inspired the Movie Concussion Journal Article
In: Physician Leadership Journal, vol. 3, no. 2, pp. 8–10, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Injury, *Football, Athletic Injuries/co [Complications], Brain Injury, Chronic, Chronic/et [Etiology], Humans, Motion Pictures as Topic
@article{Steiger2016,
title = {Meet Bennet Omalu, Md: The Physician Leader Whose Research Inspired the Movie Concussion},
author = {Steiger, B},
year = {2016},
date = {2016-01-01},
journal = {Physician Leadership Journal},
volume = {3},
number = {2},
pages = {8--10},
abstract = {The pathologist who discovered chronic traumatic encephalopathy in professional football players didn't set out to attack America's favorite sport. He didn't even know much about the game.},
keywords = {*Brain Concussion/co [Complications], *Brain Injury, *Football, Athletic Injuries/co [Complications], Brain Injury, Chronic, Chronic/et [Etiology], Humans, Motion Pictures as Topic},
pubstate = {published},
tppubtype = {article}
}
Leung, A; Shukla, S; Fallah, A; Song, D; Lin, L; Golshan, S; Tsai, A; Jak, A; Polston, G; Lee, R
Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches Journal Article
In: Neuromodulation, vol. 19, no. 2, pp. 133–141, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Headache/et [Etiology], *Headache/th [Therapy], *Transcranial Magnetic Stimulation/mt [Methods], adult, aged, Female, Humans, Male, middle aged, Neuronavigation, Neuropsychological Tests, treatment outcome
@article{Leung2016,
title = {Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches},
author = {Leung, A and Shukla, S and Fallah, A and Song, D and Lin, L and Golshan, S and Tsai, A and Jak, A and Polston, G and Lee, R},
year = {2016},
date = {2016-01-01},
journal = {Neuromodulation},
volume = {19},
number = {2},
pages = {133--141},
abstract = {OBJECTIVE: Headache is one of the most common debilitating chronic pain conditions in either active or retired military personnel with mild traumatic brain injury (MTBI). This study assessed the effect of repetitive transcranial magnetic stimulation (rTMS) in alleviating MTBI-related headache (MTBI-HA). MATERIALS AND METHOD: Veterans with MTBI-HA were randomized to receive either real rTMS (REAL group) at 10 hz for a total of 2000 pulses divided into 20 trains with one-sec inter-train interval or sham rTMS (SHAM group) at the left motor cortex (LMC) with brain magnetic resonance imaging neuronavigation guidance. Pretreatment, posttreatment one-week and four-week headache and neuropsychological assessments were conducted. RESULT: Thirty veterans were screened and twenty four (21 men and 3 women with average year-old +/- SD at 14.3 +/- 12.6) subjects' data were analyzed. A two-factor (visit x treatment) repeated measures analysis of variance (RM-ANOVA) indicated a close to significant (p = 0.06) trend of interaction between pretreatment and posttreatment one-week assessment with the intensity of the persistent daily headache decreasing from 5.7 +/- 1.9 to 2.2 +/- 2.7 and 4.6 +/- 1.3 to 3.5 +/- 2.0 for the REAL and SHAM groups, respectively. Subsequent analyses indicated REAL group demonstrated a significantly (p = 0.041) higher % of reduction in persistent headache intensity than the SHAM group (56.3 +/- 48.2% vs.15.4 +/- 43.6%) at the posttreatment one-week assessment and the trend continued to the four-week assessment. Overall, a significantly (p = 0.035) higher percentage of the subjects in the REAL group (58.3%) demonstrated at least a 50% headache intensity reduction at posttreatment one-week assessment compared with the SHAM group (16.6%). The overall composite score of functionally debilitating headache exacerbation is significantly (p = 0.017) reduced in REAL group at the posttreatment four-week assessment in comparison with the SHAM group. No major sustained change in neuropsychological assessments was noted. CONCLUSION: The studied rTMS protocol appears to be a clinically feasible and effective treatment option in managing MTBI-HA.Copyright © 2015 International Neuromodulation Society.},
keywords = {*Brain Concussion/co [Complications], *Headache/et [Etiology], *Headache/th [Therapy], *Transcranial Magnetic Stimulation/mt [Methods], adult, aged, Female, Humans, Male, middle aged, Neuronavigation, Neuropsychological Tests, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
Fralick, M; Thiruchelvam, D; Tien, H C; Redelmeier, D A
Risk of suicide after a concussion Journal Article
In: CMAJ Canadian Medical Association Journal, vol. 188, no. 7, pp. 497–504, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Suicide/sn [Statistics & Numerical Data], adult, Canada/ep [Epidemiology], Cohort Studies, Female, Humans, Long-Term Care, Longitudinal studies, Male, ONTARIO, Risk Factors
@article{Fralick2016,
title = {Risk of suicide after a concussion},
author = {Fralick, M and Thiruchelvam, D and Tien, H C and Redelmeier, D A},
year = {2016},
date = {2016-01-01},
journal = {CMAJ Canadian Medical Association Journal},
volume = {188},
number = {7},
pages = {497--504},
abstract = {BACKGROUND: Head injuries have been associated with subsequent suicide among military personnel, but outcomes after a concussion in the community are uncertain. We assessed the long-term risk of suicide after concussions occurring on weekends or weekdays in the community. METHODS: We performed a longitudinal cohort analysis of adults with diagnosis of a concussion in Ontario, Canada, from Apr. 1, 1992, to Mar. 31, 2012 (a 20-yr period), excluding severe cases that resulted in hospital admission. The primary outcome was the long-term risk of suicide after a weekend or weekday concussion. RESULTS: We identified 235,110 patients with a concussion. Their mean age was 41 years, 52% were men, and most (86%) lived in an urban location. A total of 667 subsequent suicides occurred over a median follow-up of 9.3 years, equivalent to 31 deaths per 100,000 patients annually or 3 times the population norm. Weekend concussions were associated with a one-third further increased risk of suicide compared with weekday concussions (relative risk 1.36, 95% confidence interval 1.14-1.64). The increased risk applied regardless of patients' demographic characteristics, was independent of past psychiatric conditions, became accentuated with time and exceeded the risk among military personnel. Half of these patients had visited a physician in the last week of life. INTERPRETATION: Adults with a diagnosis of concussion had an increased long-term risk of suicide, particularly after concussions on weekends. Greater attention to the long-term care of patients after a concussion in the community might save lives because deaths from suicide can be prevented.Copyright © 2016 Canadian Medical Association or its licensors.},
keywords = {*Brain Concussion/co [Complications], *Suicide/sn [Statistics \& Numerical Data], adult, Canada/ep [Epidemiology], Cohort Studies, Female, Humans, Long-Term Care, Longitudinal studies, Male, ONTARIO, Risk Factors},
pubstate = {published},
tppubtype = {article}
}
Halstead, M E
Pharmacologic Therapies for Pediatric Concussions Journal Article
In: Sports & Health, vol. 8, no. 1, pp. 50–52, 2016.
Abstract | BibTeX | Tags: *Acetaminophen/tu [Therapeutic Use], *Analgesics, *Anti-Inflammatory Agents, *Athletic Injuries/co [Complications], *Brain Concussion/co [Complications], *Post-Traumatic Headache/et [Etiology], 0 (Analgesics, 0 (Anti-Inflammatory Agents, 362O9ITL9D (Acetaminophen), Athletic Injuries/dt [Drug Therapy], Brain Concussion/dt [Drug Therapy], Child, Consensus, Humans, Non-Narcotic), Non-Narcotic/tu [Therapeutic Use], Non-Steroidal), Non-Steroidal/tu [Thera, Physicians'/sn [Statistics & Nu, Post-Traumatic Headache/dt [Drug Therapy], Practice Guidelines as Topic, Practice Patterns, Recovery of Function, Retrospective Studies
@article{Halstead2016,
title = {Pharmacologic Therapies for Pediatric Concussions},
author = {Halstead, M E},
year = {2016},
date = {2016-01-01},
journal = {Sports \& Health},
volume = {8},
number = {1},
pages = {50--52},
abstract = {CONTEXT: Pediatric concussions are common, and emphasis on correct diagnosis and management is stressed in consensus guidelines. Medications may have a role in management of concussion, but no consensus exists regarding appropriate pharmacologic therapy. EVIDENCE ACQUISITION: Nonsystematic review. STUDY DESIGN: Clinical review. LEVEL OF EVIDENCE: Level 4. RESULTS: There is limited evidence for hypertonic saline to improve posttraumatic headache in the emergency department setting. There is essentially no evidence for the use of any other medication in management of pediatric sport-related concussion. CONCLUSION: Further research is necessary to determine whether there is benefit to the use of any pharmacotherapy in the management of pediatric-aged athletes with concussions.},
keywords = {*Acetaminophen/tu [Therapeutic Use], *Analgesics, *Anti-Inflammatory Agents, *Athletic Injuries/co [Complications], *Brain Concussion/co [Complications], *Post-Traumatic Headache/et [Etiology], 0 (Analgesics, 0 (Anti-Inflammatory Agents, 362O9ITL9D (Acetaminophen), Athletic Injuries/dt [Drug Therapy], Brain Concussion/dt [Drug Therapy], Child, Consensus, Humans, Non-Narcotic), Non-Narcotic/tu [Therapeutic Use], Non-Steroidal), Non-Steroidal/tu [Thera, Physicians'/sn [Statistics \& Nu, Post-Traumatic Headache/dt [Drug Therapy], Practice Guidelines as Topic, Practice Patterns, Recovery of Function, Retrospective Studies},
pubstate = {published},
tppubtype = {article}
}
Mollayeva, T; Mollayeva, S; Colantonio, A
The Risk of Sleep Disorder Among Persons with Mild Traumatic Brain Injury Journal Article
In: Current Neurology & Neuroscience Reports, vol. 16, no. 6, pp. 55, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Sleep Wake Disorders/et [Etiology], Animals, Brain Concussion/pa [Pathology], Brain/pa [Pathology], Humans, Risk Factors, Sleep Wake Disorders/ge [Genetics], wakefulness
@article{Mollayeva2016,
title = {The Risk of Sleep Disorder Among Persons with Mild Traumatic Brain Injury},
author = {Mollayeva, T and Mollayeva, S and Colantonio, A},
year = {2016},
date = {2016-01-01},
journal = {Current Neurology \& Neuroscience Reports},
volume = {16},
number = {6},
pages = {55},
abstract = {Sleep disorders and mild traumatic brain injury (mTBI) are among the most commonly occurring neurological problems clinicians encounter simultaneously. Each can cause the other, and both share common predisposing factors. An important question that remains to be addressed is whether high-risk groups can be defined. We observed an accumulation of considerable knowledge on sleep dysfunction in mTBI in recently published works. The results highlight sleep disturbances in mTBI as the product of diverse internal and external influences, acting on a genetically determined substrate. This may partially explain the clinical heterogeneity of mTBI, pointing to the importance of establishing an accurate history on the onset and course of a specific sleep disorder in the early stages post-mTBI in the individual patient. Such an approach will aid not only diagnosis and treatment but may also lead to identification of disorders whose symptoms mimic those of TBI and thereby direct the most suitable treatment and management.},
keywords = {*Brain Concussion/co [Complications], *Sleep Wake Disorders/et [Etiology], Animals, Brain Concussion/pa [Pathology], Brain/pa [Pathology], Humans, Risk Factors, Sleep Wake Disorders/ge [Genetics], wakefulness},
pubstate = {published},
tppubtype = {article}
}
Underwood, E
NEUROSCIENCE. Can brain scans reveal concussion-linked disease? Journal Article
In: Science, vol. 352, no. 6288, pp. 881, 2016.
BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Injury, *Neuroimaging/mt [Methods], *Positron-Emission Tomography/mt [Methods], *tau Proteins/an [Analysis], 0 (7-(6-fluoropyridin-3-yl)-5H-pyrido(4, 0 (Carbolines), 0 (tau Proteins), 3-b)indole, adult, Carbolines/pk [Pharmacokinetics], Chronic/di [Diagnosis], Chronic/et [Etiology], Humans
@article{Underwood2016,
title = {NEUROSCIENCE. Can brain scans reveal concussion-linked disease?},
author = {Underwood, E},
year = {2016},
date = {2016-01-01},
journal = {Science},
volume = {352},
number = {6288},
pages = {881},
keywords = {*Brain Concussion/co [Complications], *Brain Injury, *Neuroimaging/mt [Methods], *Positron-Emission Tomography/mt [Methods], *tau Proteins/an [Analysis], 0 (7-(6-fluoropyridin-3-yl)-5H-pyrido(4, 0 (Carbolines), 0 (tau Proteins), 3-b)indole, adult, Carbolines/pk [Pharmacokinetics], Chronic/di [Diagnosis], Chronic/et [Etiology], Humans},
pubstate = {published},
tppubtype = {article}
}
Stewart, W; McNamara, P H; Lawlor, B; Hutchinson, S; Farrell, M
Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union? Journal Article
In: Qjm, vol. 109, no. 1, pp. 11–15, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Injury, *Brain/pp [Physiopathology], *Football/in [Injuries], *Neurodegenerative Diseases/pp [Physiopathology], Chronic/pa [Pathology], Humans, Magnetic Resonance Imaging, Male, middle aged, neurologic examination
@article{Stewart2016,
title = {Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union?},
author = {Stewart, W and McNamara, P H and Lawlor, B and Hutchinson, S and Farrell, M},
year = {2016},
date = {2016-01-01},
journal = {Qjm},
volume = {109},
number = {1},
pages = {11--15},
abstract = {The association between exposure to head injury and increased risk of neurodegenerative disease, specifically chronic traumatic encephalopathy (CTE), is widely recognized. Historically, this was largely considered a phenomenon restricted to boxers, with more recent case series identifying further 'high risk' individuals, such as former American footballers, or military personnel. However, in all cases thus far reported, it is clear that it is the exposure to head injury which is associated with increased dementia risk, and not the circumstances or environment of exposure. As such, there is considerable potential for under-recognition of CTE in patients presenting with neurodegenerative disease, particularly where head injury exposure might have been historical and through sport. This article reviews current understanding of CTE and, via an illustrative case in rugby union, highlights the value of a detailed history on head injury and also draws attention to imaging studies in assessing patients with neurodegenerative disease. Copyright © The Author 2015. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com.},
keywords = {*Brain Concussion/co [Complications], *Brain Injury, *Brain/pp [Physiopathology], *Football/in [Injuries], *Neurodegenerative Diseases/pp [Physiopathology], Chronic/pa [Pathology], Humans, Magnetic Resonance Imaging, Male, middle aged, neurologic examination},
pubstate = {published},
tppubtype = {article}
}
Monaco 3rd, E A; Tempel, Z
Concussion related to white matter abnormalities and cognitive dysfunction in aging athletes Journal Article
In: Neurosurgery, vol. 76, no. 4, pp. N10–1, 2015.
BibTeX | Tags: *Athletes, *Brain Concussion/co [Complications], *Cognition Disorders/et [Etiology], *White Matter/pa [Pathology], aging, Brain Concussion/pa [Pathology], Humans, middle aged, Neuropsychological Tests
@article{Monaco3rd2015,
title = {Concussion related to white matter abnormalities and cognitive dysfunction in aging athletes},
author = {{Monaco 3rd}, E A and Tempel, Z},
year = {2015},
date = {2015-01-01},
journal = {Neurosurgery},
volume = {76},
number = {4},
pages = {N10--1},
keywords = {*Athletes, *Brain Concussion/co [Complications], *Cognition Disorders/et [Etiology], *White Matter/pa [Pathology], aging, Brain Concussion/pa [Pathology], Humans, middle aged, Neuropsychological Tests},
pubstate = {published},
tppubtype = {article}
}
Raukar, N; Chao, L
Concussion: a primer for the physician Journal Article
In: Rhode Island Medicine, vol. 98, no. 6, pp. 27–29, 2015.
BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Concussion/pp [Physiopathology], *Brain Concussion/th [Therapy], *Sports Medicine/st [Standards], Alzheimer Disease/ep [Epidemiology], Athletes, Brain/pp [Physiopathology], Humans, Schools
@article{Raukar2015,
title = {Concussion: a primer for the physician},
author = {Raukar, N and Chao, L},
year = {2015},
date = {2015-01-01},
journal = {Rhode Island Medicine},
volume = {98},
number = {6},
pages = {27--29},
keywords = {*Brain Concussion/co [Complications], *Brain Concussion/pp [Physiopathology], *Brain Concussion/th [Therapy], *Sports Medicine/st [Standards], Alzheimer Disease/ep [Epidemiology], Athletes, Brain/pp [Physiopathology], Humans, Schools},
pubstate = {published},
tppubtype = {article}
}
Dretsch, M N; Silverberg, N D; Iverson, G L
Multiple Past Concussions Are Associated with Ongoing Post-Concussive Symptoms but Not Cognitive Impairment in Active-Duty Army Soldiers Journal Article
In: Journal of Neurotrauma, vol. 32, no. 17, pp. 1301–1306, 2015.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Cognition Disorders/di [Diagnosis], *Military Personnel/sn [Statistics & Numerical Dat, *Post-Concussion Syndrome/di [Diagnosis], adult, Brain Concussion/ep [Epidemiology], Cognition Disorders/ep [Epidemiology], Cognition Disorders/et [Etiology], Female, Humans, Male, Post-Concussion Syndrome/ep [Epidemiology], Post-Concussion Syndrome/et [Etiology], United States/ep [Epidemiology], Young Adult
@article{Dretsch2015,
title = {Multiple Past Concussions Are Associated with Ongoing Post-Concussive Symptoms but Not Cognitive Impairment in Active-Duty Army Soldiers},
author = {Dretsch, M N and Silverberg, N D and Iverson, G L},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neurotrauma},
volume = {32},
number = {17},
pages = {1301--1306},
abstract = {The extent to which multiple past concussions are associated with lingering symptoms or mental health problems in military service members is not well understood. The purpose of this study was to examine the association between lifetime concussion history, cognitive functioning, general health, and psychological health in a large sample of fit-for-duty U.S. Army soldiers preparing for deployment. Data on 458 active-duty soldiers were collected and analyzed. A computerized cognitive screening battery (CNS-Vital Signs()) was used to assess complex attention (CA), reaction time (RT), processing speed (PS), cognitive flexibility (CF), and memory. Health questionnaires included the Neurobehavioral Symptom Inventory (NSI), PTSD Checklist-Military Version (PCL-M), Zung Depression and Anxiety Scales (ZDS; ZAS), Perceived Stress Scale (PSS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and the Alcohol Use and Dependency Identification Test (AUDIT). Soldiers with a history of multiple concussions (i.e., three or more concussions) had significantly greater post-concussive symptom scores compared with those with zero (d=1.83, large effect), one (d=0.64, medium effect), and two (d=0.64, medium effect) prior concussions. Although the group with three or more concussions also reported more traumatic stress symptoms, the results revealed that traumatic stress was a mediator between concussions and post-concussive symptom severity. There were no significant differences on neurocognitive testing between the number of concussions. These results add to the accumulating evidence suggesting that most individuals recover from one or two prior concussions, but there is a greater risk for ongoing symptoms if one exceeds this number of injuries.},
keywords = {*Brain Concussion/co [Complications], *Cognition Disorders/di [Diagnosis], *Military Personnel/sn [Statistics \& Numerical Dat, *Post-Concussion Syndrome/di [Diagnosis], adult, Brain Concussion/ep [Epidemiology], Cognition Disorders/ep [Epidemiology], Cognition Disorders/et [Etiology], Female, Humans, Male, Post-Concussion Syndrome/ep [Epidemiology], Post-Concussion Syndrome/et [Etiology], United States/ep [Epidemiology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Thornton, A E; Cox, D N; Whitfield, K; Fouladi, R T
Cumulative concussion exposure in rugby players: neurocognitive and symptomatic outcomes Journal Article
In: Journal of Clinical & Experimental Neuropsychology, vol. 30, no. 4, pp. 398–409, 2008.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *COGNITION, *Cognition Disorders/et [Etiology], *Football/in [Injuries], adult, Age Factors, aged, Brain Concussion/di [Diagnosis], Female, Humans, Male, middle aged, Neuropsychological Tests, Predictive Value of Tests, REGRESSION analysis, Surveys and Questionnaires, Trauma Severity Indices
@article{Thornton2008a,
title = {Cumulative concussion exposure in rugby players: neurocognitive and symptomatic outcomes},
author = {Thornton, A E and Cox, D N and Whitfield, K and Fouladi, R T},
year = {2008},
date = {2008-01-01},
journal = {Journal of Clinical \& Experimental Neuropsychology},
volume = {30},
number = {4},
pages = {398--409},
abstract = {A total of 111 rugby players underwent comprehensive testing to determine the impact of self-reported concussion exposure. Reliable estimates of concussion exposure were associated with an increase in postconcussion symptoms (PCS), but not diminished neurocognitive functioning. Importantly, the effects of concussion exposure on PCS varied as a function of player status. More specifically, extent of concussion exposure was associated with increased memory complaints and overall PCS endorsements in a dose-dependent manner for retired and older recreational players, but not for those who were younger and playing at more competitive levels. Future work should systematically evaluate the constituent participant factors that may influence differential concussion outcomes.},
keywords = {*Brain Concussion/co [Complications], *COGNITION, *Cognition Disorders/et [Etiology], *Football/in [Injuries], adult, Age Factors, aged, Brain Concussion/di [Diagnosis], Female, Humans, Male, middle aged, Neuropsychological Tests, Predictive Value of Tests, REGRESSION analysis, Surveys and Questionnaires, Trauma Severity Indices},
pubstate = {published},
tppubtype = {article}
}
Auerbach, P S; Waggoner 2nd, W H
It's Time to Change the Rules Journal Article
In: JAMA, vol. 316, no. 12, pp. 1260–1261, 2016.
@article{Auerbach2016,
title = {It's Time to Change the Rules},
author = {Auerbach, P S and {Waggoner 2nd}, W H},
year = {2016},
date = {2016-01-01},
journal = {JAMA},
volume = {316},
number = {12},
pages = {1260--1261},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Steiger, B
Meet Bennet Omalu, Md: The Physician Leader Whose Research Inspired the Movie Concussion Journal Article
In: Physician Leadership Journal, vol. 3, no. 2, pp. 8–10, 2016.
@article{Steiger2016,
title = {Meet Bennet Omalu, Md: The Physician Leader Whose Research Inspired the Movie Concussion},
author = {Steiger, B},
year = {2016},
date = {2016-01-01},
journal = {Physician Leadership Journal},
volume = {3},
number = {2},
pages = {8--10},
abstract = {The pathologist who discovered chronic traumatic encephalopathy in professional football players didn't set out to attack America's favorite sport. He didn't even know much about the game.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Leung, A; Shukla, S; Fallah, A; Song, D; Lin, L; Golshan, S; Tsai, A; Jak, A; Polston, G; Lee, R
Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches Journal Article
In: Neuromodulation, vol. 19, no. 2, pp. 133–141, 2016.
@article{Leung2016,
title = {Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches},
author = {Leung, A and Shukla, S and Fallah, A and Song, D and Lin, L and Golshan, S and Tsai, A and Jak, A and Polston, G and Lee, R},
year = {2016},
date = {2016-01-01},
journal = {Neuromodulation},
volume = {19},
number = {2},
pages = {133--141},
abstract = {OBJECTIVE: Headache is one of the most common debilitating chronic pain conditions in either active or retired military personnel with mild traumatic brain injury (MTBI). This study assessed the effect of repetitive transcranial magnetic stimulation (rTMS) in alleviating MTBI-related headache (MTBI-HA). MATERIALS AND METHOD: Veterans with MTBI-HA were randomized to receive either real rTMS (REAL group) at 10 hz for a total of 2000 pulses divided into 20 trains with one-sec inter-train interval or sham rTMS (SHAM group) at the left motor cortex (LMC) with brain magnetic resonance imaging neuronavigation guidance. Pretreatment, posttreatment one-week and four-week headache and neuropsychological assessments were conducted. RESULT: Thirty veterans were screened and twenty four (21 men and 3 women with average year-old +/- SD at 14.3 +/- 12.6) subjects' data were analyzed. A two-factor (visit x treatment) repeated measures analysis of variance (RM-ANOVA) indicated a close to significant (p = 0.06) trend of interaction between pretreatment and posttreatment one-week assessment with the intensity of the persistent daily headache decreasing from 5.7 +/- 1.9 to 2.2 +/- 2.7 and 4.6 +/- 1.3 to 3.5 +/- 2.0 for the REAL and SHAM groups, respectively. Subsequent analyses indicated REAL group demonstrated a significantly (p = 0.041) higher % of reduction in persistent headache intensity than the SHAM group (56.3 +/- 48.2% vs.15.4 +/- 43.6%) at the posttreatment one-week assessment and the trend continued to the four-week assessment. Overall, a significantly (p = 0.035) higher percentage of the subjects in the REAL group (58.3%) demonstrated at least a 50% headache intensity reduction at posttreatment one-week assessment compared with the SHAM group (16.6%). The overall composite score of functionally debilitating headache exacerbation is significantly (p = 0.017) reduced in REAL group at the posttreatment four-week assessment in comparison with the SHAM group. No major sustained change in neuropsychological assessments was noted. CONCLUSION: The studied rTMS protocol appears to be a clinically feasible and effective treatment option in managing MTBI-HA.Copyright © 2015 International Neuromodulation Society.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Fralick, M; Thiruchelvam, D; Tien, H C; Redelmeier, D A
Risk of suicide after a concussion Journal Article
In: CMAJ Canadian Medical Association Journal, vol. 188, no. 7, pp. 497–504, 2016.
@article{Fralick2016,
title = {Risk of suicide after a concussion},
author = {Fralick, M and Thiruchelvam, D and Tien, H C and Redelmeier, D A},
year = {2016},
date = {2016-01-01},
journal = {CMAJ Canadian Medical Association Journal},
volume = {188},
number = {7},
pages = {497--504},
abstract = {BACKGROUND: Head injuries have been associated with subsequent suicide among military personnel, but outcomes after a concussion in the community are uncertain. We assessed the long-term risk of suicide after concussions occurring on weekends or weekdays in the community. METHODS: We performed a longitudinal cohort analysis of adults with diagnosis of a concussion in Ontario, Canada, from Apr. 1, 1992, to Mar. 31, 2012 (a 20-yr period), excluding severe cases that resulted in hospital admission. The primary outcome was the long-term risk of suicide after a weekend or weekday concussion. RESULTS: We identified 235,110 patients with a concussion. Their mean age was 41 years, 52% were men, and most (86%) lived in an urban location. A total of 667 subsequent suicides occurred over a median follow-up of 9.3 years, equivalent to 31 deaths per 100,000 patients annually or 3 times the population norm. Weekend concussions were associated with a one-third further increased risk of suicide compared with weekday concussions (relative risk 1.36, 95% confidence interval 1.14-1.64). The increased risk applied regardless of patients' demographic characteristics, was independent of past psychiatric conditions, became accentuated with time and exceeded the risk among military personnel. Half of these patients had visited a physician in the last week of life. INTERPRETATION: Adults with a diagnosis of concussion had an increased long-term risk of suicide, particularly after concussions on weekends. Greater attention to the long-term care of patients after a concussion in the community might save lives because deaths from suicide can be prevented.Copyright © 2016 Canadian Medical Association or its licensors.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Halstead, M E
Pharmacologic Therapies for Pediatric Concussions Journal Article
In: Sports & Health, vol. 8, no. 1, pp. 50–52, 2016.
@article{Halstead2016,
title = {Pharmacologic Therapies for Pediatric Concussions},
author = {Halstead, M E},
year = {2016},
date = {2016-01-01},
journal = {Sports \& Health},
volume = {8},
number = {1},
pages = {50--52},
abstract = {CONTEXT: Pediatric concussions are common, and emphasis on correct diagnosis and management is stressed in consensus guidelines. Medications may have a role in management of concussion, but no consensus exists regarding appropriate pharmacologic therapy. EVIDENCE ACQUISITION: Nonsystematic review. STUDY DESIGN: Clinical review. LEVEL OF EVIDENCE: Level 4. RESULTS: There is limited evidence for hypertonic saline to improve posttraumatic headache in the emergency department setting. There is essentially no evidence for the use of any other medication in management of pediatric sport-related concussion. CONCLUSION: Further research is necessary to determine whether there is benefit to the use of any pharmacotherapy in the management of pediatric-aged athletes with concussions.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Mollayeva, T; Mollayeva, S; Colantonio, A
The Risk of Sleep Disorder Among Persons with Mild Traumatic Brain Injury Journal Article
In: Current Neurology & Neuroscience Reports, vol. 16, no. 6, pp. 55, 2016.
@article{Mollayeva2016,
title = {The Risk of Sleep Disorder Among Persons with Mild Traumatic Brain Injury},
author = {Mollayeva, T and Mollayeva, S and Colantonio, A},
year = {2016},
date = {2016-01-01},
journal = {Current Neurology \& Neuroscience Reports},
volume = {16},
number = {6},
pages = {55},
abstract = {Sleep disorders and mild traumatic brain injury (mTBI) are among the most commonly occurring neurological problems clinicians encounter simultaneously. Each can cause the other, and both share common predisposing factors. An important question that remains to be addressed is whether high-risk groups can be defined. We observed an accumulation of considerable knowledge on sleep dysfunction in mTBI in recently published works. The results highlight sleep disturbances in mTBI as the product of diverse internal and external influences, acting on a genetically determined substrate. This may partially explain the clinical heterogeneity of mTBI, pointing to the importance of establishing an accurate history on the onset and course of a specific sleep disorder in the early stages post-mTBI in the individual patient. Such an approach will aid not only diagnosis and treatment but may also lead to identification of disorders whose symptoms mimic those of TBI and thereby direct the most suitable treatment and management.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Underwood, E
NEUROSCIENCE. Can brain scans reveal concussion-linked disease? Journal Article
In: Science, vol. 352, no. 6288, pp. 881, 2016.
@article{Underwood2016,
title = {NEUROSCIENCE. Can brain scans reveal concussion-linked disease?},
author = {Underwood, E},
year = {2016},
date = {2016-01-01},
journal = {Science},
volume = {352},
number = {6288},
pages = {881},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Stewart, W; McNamara, P H; Lawlor, B; Hutchinson, S; Farrell, M
Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union? Journal Article
In: Qjm, vol. 109, no. 1, pp. 11–15, 2016.
@article{Stewart2016,
title = {Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union?},
author = {Stewart, W and McNamara, P H and Lawlor, B and Hutchinson, S and Farrell, M},
year = {2016},
date = {2016-01-01},
journal = {Qjm},
volume = {109},
number = {1},
pages = {11--15},
abstract = {The association between exposure to head injury and increased risk of neurodegenerative disease, specifically chronic traumatic encephalopathy (CTE), is widely recognized. Historically, this was largely considered a phenomenon restricted to boxers, with more recent case series identifying further 'high risk' individuals, such as former American footballers, or military personnel. However, in all cases thus far reported, it is clear that it is the exposure to head injury which is associated with increased dementia risk, and not the circumstances or environment of exposure. As such, there is considerable potential for under-recognition of CTE in patients presenting with neurodegenerative disease, particularly where head injury exposure might have been historical and through sport. This article reviews current understanding of CTE and, via an illustrative case in rugby union, highlights the value of a detailed history on head injury and also draws attention to imaging studies in assessing patients with neurodegenerative disease. Copyright © The Author 2015. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Monaco 3rd, E A; Tempel, Z
Concussion related to white matter abnormalities and cognitive dysfunction in aging athletes Journal Article
In: Neurosurgery, vol. 76, no. 4, pp. N10–1, 2015.
@article{Monaco3rd2015,
title = {Concussion related to white matter abnormalities and cognitive dysfunction in aging athletes},
author = {{Monaco 3rd}, E A and Tempel, Z},
year = {2015},
date = {2015-01-01},
journal = {Neurosurgery},
volume = {76},
number = {4},
pages = {N10--1},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Raukar, N; Chao, L
Concussion: a primer for the physician Journal Article
In: Rhode Island Medicine, vol. 98, no. 6, pp. 27–29, 2015.
@article{Raukar2015,
title = {Concussion: a primer for the physician},
author = {Raukar, N and Chao, L},
year = {2015},
date = {2015-01-01},
journal = {Rhode Island Medicine},
volume = {98},
number = {6},
pages = {27--29},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Dretsch, M N; Silverberg, N D; Iverson, G L
Multiple Past Concussions Are Associated with Ongoing Post-Concussive Symptoms but Not Cognitive Impairment in Active-Duty Army Soldiers Journal Article
In: Journal of Neurotrauma, vol. 32, no. 17, pp. 1301–1306, 2015.
@article{Dretsch2015,
title = {Multiple Past Concussions Are Associated with Ongoing Post-Concussive Symptoms but Not Cognitive Impairment in Active-Duty Army Soldiers},
author = {Dretsch, M N and Silverberg, N D and Iverson, G L},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neurotrauma},
volume = {32},
number = {17},
pages = {1301--1306},
abstract = {The extent to which multiple past concussions are associated with lingering symptoms or mental health problems in military service members is not well understood. The purpose of this study was to examine the association between lifetime concussion history, cognitive functioning, general health, and psychological health in a large sample of fit-for-duty U.S. Army soldiers preparing for deployment. Data on 458 active-duty soldiers were collected and analyzed. A computerized cognitive screening battery (CNS-Vital Signs()) was used to assess complex attention (CA), reaction time (RT), processing speed (PS), cognitive flexibility (CF), and memory. Health questionnaires included the Neurobehavioral Symptom Inventory (NSI), PTSD Checklist-Military Version (PCL-M), Zung Depression and Anxiety Scales (ZDS; ZAS), Perceived Stress Scale (PSS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and the Alcohol Use and Dependency Identification Test (AUDIT). Soldiers with a history of multiple concussions (i.e., three or more concussions) had significantly greater post-concussive symptom scores compared with those with zero (d=1.83, large effect), one (d=0.64, medium effect), and two (d=0.64, medium effect) prior concussions. Although the group with three or more concussions also reported more traumatic stress symptoms, the results revealed that traumatic stress was a mediator between concussions and post-concussive symptom severity. There were no significant differences on neurocognitive testing between the number of concussions. These results add to the accumulating evidence suggesting that most individuals recover from one or two prior concussions, but there is a greater risk for ongoing symptoms if one exceeds this number of injuries.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Thornton, A E; Cox, D N; Whitfield, K; Fouladi, R T
Cumulative concussion exposure in rugby players: neurocognitive and symptomatic outcomes Journal Article
In: Journal of Clinical & Experimental Neuropsychology, vol. 30, no. 4, pp. 398–409, 2008.
@article{Thornton2008a,
title = {Cumulative concussion exposure in rugby players: neurocognitive and symptomatic outcomes},
author = {Thornton, A E and Cox, D N and Whitfield, K and Fouladi, R T},
year = {2008},
date = {2008-01-01},
journal = {Journal of Clinical \& Experimental Neuropsychology},
volume = {30},
number = {4},
pages = {398--409},
abstract = {A total of 111 rugby players underwent comprehensive testing to determine the impact of self-reported concussion exposure. Reliable estimates of concussion exposure were associated with an increase in postconcussion symptoms (PCS), but not diminished neurocognitive functioning. Importantly, the effects of concussion exposure on PCS varied as a function of player status. More specifically, extent of concussion exposure was associated with increased memory complaints and overall PCS endorsements in a dose-dependent manner for retired and older recreational players, but not for those who were younger and playing at more competitive levels. Future work should systematically evaluate the constituent participant factors that may influence differential concussion outcomes.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Auerbach, P S; Waggoner 2nd, W H
It's Time to Change the Rules Journal Article
In: JAMA, vol. 316, no. 12, pp. 1260–1261, 2016.
BibTeX | Tags: *Brain Concussion/co [Complications], *Football/in [Injuries], adult, Brain Concussion/et [Etiology], Brain Concussion/pc [Prevention & Control], Football/st [Standards], Humans, Male, Safety/st [Standards], UNITED States
@article{Auerbach2016,
title = {It's Time to Change the Rules},
author = {Auerbach, P S and {Waggoner 2nd}, W H},
year = {2016},
date = {2016-01-01},
journal = {JAMA},
volume = {316},
number = {12},
pages = {1260--1261},
keywords = {*Brain Concussion/co [Complications], *Football/in [Injuries], adult, Brain Concussion/et [Etiology], Brain Concussion/pc [Prevention \& Control], Football/st [Standards], Humans, Male, Safety/st [Standards], UNITED States},
pubstate = {published},
tppubtype = {article}
}
Steiger, B
Meet Bennet Omalu, Md: The Physician Leader Whose Research Inspired the Movie Concussion Journal Article
In: Physician Leadership Journal, vol. 3, no. 2, pp. 8–10, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Injury, *Football, Athletic Injuries/co [Complications], Brain Injury, Chronic, Chronic/et [Etiology], Humans, Motion Pictures as Topic
@article{Steiger2016,
title = {Meet Bennet Omalu, Md: The Physician Leader Whose Research Inspired the Movie Concussion},
author = {Steiger, B},
year = {2016},
date = {2016-01-01},
journal = {Physician Leadership Journal},
volume = {3},
number = {2},
pages = {8--10},
abstract = {The pathologist who discovered chronic traumatic encephalopathy in professional football players didn't set out to attack America's favorite sport. He didn't even know much about the game.},
keywords = {*Brain Concussion/co [Complications], *Brain Injury, *Football, Athletic Injuries/co [Complications], Brain Injury, Chronic, Chronic/et [Etiology], Humans, Motion Pictures as Topic},
pubstate = {published},
tppubtype = {article}
}
Leung, A; Shukla, S; Fallah, A; Song, D; Lin, L; Golshan, S; Tsai, A; Jak, A; Polston, G; Lee, R
Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches Journal Article
In: Neuromodulation, vol. 19, no. 2, pp. 133–141, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Headache/et [Etiology], *Headache/th [Therapy], *Transcranial Magnetic Stimulation/mt [Methods], adult, aged, Female, Humans, Male, middle aged, Neuronavigation, Neuropsychological Tests, treatment outcome
@article{Leung2016,
title = {Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches},
author = {Leung, A and Shukla, S and Fallah, A and Song, D and Lin, L and Golshan, S and Tsai, A and Jak, A and Polston, G and Lee, R},
year = {2016},
date = {2016-01-01},
journal = {Neuromodulation},
volume = {19},
number = {2},
pages = {133--141},
abstract = {OBJECTIVE: Headache is one of the most common debilitating chronic pain conditions in either active or retired military personnel with mild traumatic brain injury (MTBI). This study assessed the effect of repetitive transcranial magnetic stimulation (rTMS) in alleviating MTBI-related headache (MTBI-HA). MATERIALS AND METHOD: Veterans with MTBI-HA were randomized to receive either real rTMS (REAL group) at 10 hz for a total of 2000 pulses divided into 20 trains with one-sec inter-train interval or sham rTMS (SHAM group) at the left motor cortex (LMC) with brain magnetic resonance imaging neuronavigation guidance. Pretreatment, posttreatment one-week and four-week headache and neuropsychological assessments were conducted. RESULT: Thirty veterans were screened and twenty four (21 men and 3 women with average year-old +/- SD at 14.3 +/- 12.6) subjects' data were analyzed. A two-factor (visit x treatment) repeated measures analysis of variance (RM-ANOVA) indicated a close to significant (p = 0.06) trend of interaction between pretreatment and posttreatment one-week assessment with the intensity of the persistent daily headache decreasing from 5.7 +/- 1.9 to 2.2 +/- 2.7 and 4.6 +/- 1.3 to 3.5 +/- 2.0 for the REAL and SHAM groups, respectively. Subsequent analyses indicated REAL group demonstrated a significantly (p = 0.041) higher % of reduction in persistent headache intensity than the SHAM group (56.3 +/- 48.2% vs.15.4 +/- 43.6%) at the posttreatment one-week assessment and the trend continued to the four-week assessment. Overall, a significantly (p = 0.035) higher percentage of the subjects in the REAL group (58.3%) demonstrated at least a 50% headache intensity reduction at posttreatment one-week assessment compared with the SHAM group (16.6%). The overall composite score of functionally debilitating headache exacerbation is significantly (p = 0.017) reduced in REAL group at the posttreatment four-week assessment in comparison with the SHAM group. No major sustained change in neuropsychological assessments was noted. CONCLUSION: The studied rTMS protocol appears to be a clinically feasible and effective treatment option in managing MTBI-HA.Copyright © 2015 International Neuromodulation Society.},
keywords = {*Brain Concussion/co [Complications], *Headache/et [Etiology], *Headache/th [Therapy], *Transcranial Magnetic Stimulation/mt [Methods], adult, aged, Female, Humans, Male, middle aged, Neuronavigation, Neuropsychological Tests, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
Fralick, M; Thiruchelvam, D; Tien, H C; Redelmeier, D A
Risk of suicide after a concussion Journal Article
In: CMAJ Canadian Medical Association Journal, vol. 188, no. 7, pp. 497–504, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Suicide/sn [Statistics & Numerical Data], adult, Canada/ep [Epidemiology], Cohort Studies, Female, Humans, Long-Term Care, Longitudinal studies, Male, ONTARIO, Risk Factors
@article{Fralick2016,
title = {Risk of suicide after a concussion},
author = {Fralick, M and Thiruchelvam, D and Tien, H C and Redelmeier, D A},
year = {2016},
date = {2016-01-01},
journal = {CMAJ Canadian Medical Association Journal},
volume = {188},
number = {7},
pages = {497--504},
abstract = {BACKGROUND: Head injuries have been associated with subsequent suicide among military personnel, but outcomes after a concussion in the community are uncertain. We assessed the long-term risk of suicide after concussions occurring on weekends or weekdays in the community. METHODS: We performed a longitudinal cohort analysis of adults with diagnosis of a concussion in Ontario, Canada, from Apr. 1, 1992, to Mar. 31, 2012 (a 20-yr period), excluding severe cases that resulted in hospital admission. The primary outcome was the long-term risk of suicide after a weekend or weekday concussion. RESULTS: We identified 235,110 patients with a concussion. Their mean age was 41 years, 52% were men, and most (86%) lived in an urban location. A total of 667 subsequent suicides occurred over a median follow-up of 9.3 years, equivalent to 31 deaths per 100,000 patients annually or 3 times the population norm. Weekend concussions were associated with a one-third further increased risk of suicide compared with weekday concussions (relative risk 1.36, 95% confidence interval 1.14-1.64). The increased risk applied regardless of patients' demographic characteristics, was independent of past psychiatric conditions, became accentuated with time and exceeded the risk among military personnel. Half of these patients had visited a physician in the last week of life. INTERPRETATION: Adults with a diagnosis of concussion had an increased long-term risk of suicide, particularly after concussions on weekends. Greater attention to the long-term care of patients after a concussion in the community might save lives because deaths from suicide can be prevented.Copyright © 2016 Canadian Medical Association or its licensors.},
keywords = {*Brain Concussion/co [Complications], *Suicide/sn [Statistics \& Numerical Data], adult, Canada/ep [Epidemiology], Cohort Studies, Female, Humans, Long-Term Care, Longitudinal studies, Male, ONTARIO, Risk Factors},
pubstate = {published},
tppubtype = {article}
}
Halstead, M E
Pharmacologic Therapies for Pediatric Concussions Journal Article
In: Sports & Health, vol. 8, no. 1, pp. 50–52, 2016.
Abstract | BibTeX | Tags: *Acetaminophen/tu [Therapeutic Use], *Analgesics, *Anti-Inflammatory Agents, *Athletic Injuries/co [Complications], *Brain Concussion/co [Complications], *Post-Traumatic Headache/et [Etiology], 0 (Analgesics, 0 (Anti-Inflammatory Agents, 362O9ITL9D (Acetaminophen), Athletic Injuries/dt [Drug Therapy], Brain Concussion/dt [Drug Therapy], Child, Consensus, Humans, Non-Narcotic), Non-Narcotic/tu [Therapeutic Use], Non-Steroidal), Non-Steroidal/tu [Thera, Physicians'/sn [Statistics & Nu, Post-Traumatic Headache/dt [Drug Therapy], Practice Guidelines as Topic, Practice Patterns, Recovery of Function, Retrospective Studies
@article{Halstead2016,
title = {Pharmacologic Therapies for Pediatric Concussions},
author = {Halstead, M E},
year = {2016},
date = {2016-01-01},
journal = {Sports \& Health},
volume = {8},
number = {1},
pages = {50--52},
abstract = {CONTEXT: Pediatric concussions are common, and emphasis on correct diagnosis and management is stressed in consensus guidelines. Medications may have a role in management of concussion, but no consensus exists regarding appropriate pharmacologic therapy. EVIDENCE ACQUISITION: Nonsystematic review. STUDY DESIGN: Clinical review. LEVEL OF EVIDENCE: Level 4. RESULTS: There is limited evidence for hypertonic saline to improve posttraumatic headache in the emergency department setting. There is essentially no evidence for the use of any other medication in management of pediatric sport-related concussion. CONCLUSION: Further research is necessary to determine whether there is benefit to the use of any pharmacotherapy in the management of pediatric-aged athletes with concussions.},
keywords = {*Acetaminophen/tu [Therapeutic Use], *Analgesics, *Anti-Inflammatory Agents, *Athletic Injuries/co [Complications], *Brain Concussion/co [Complications], *Post-Traumatic Headache/et [Etiology], 0 (Analgesics, 0 (Anti-Inflammatory Agents, 362O9ITL9D (Acetaminophen), Athletic Injuries/dt [Drug Therapy], Brain Concussion/dt [Drug Therapy], Child, Consensus, Humans, Non-Narcotic), Non-Narcotic/tu [Therapeutic Use], Non-Steroidal), Non-Steroidal/tu [Thera, Physicians'/sn [Statistics \& Nu, Post-Traumatic Headache/dt [Drug Therapy], Practice Guidelines as Topic, Practice Patterns, Recovery of Function, Retrospective Studies},
pubstate = {published},
tppubtype = {article}
}
Mollayeva, T; Mollayeva, S; Colantonio, A
The Risk of Sleep Disorder Among Persons with Mild Traumatic Brain Injury Journal Article
In: Current Neurology & Neuroscience Reports, vol. 16, no. 6, pp. 55, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Sleep Wake Disorders/et [Etiology], Animals, Brain Concussion/pa [Pathology], Brain/pa [Pathology], Humans, Risk Factors, Sleep Wake Disorders/ge [Genetics], wakefulness
@article{Mollayeva2016,
title = {The Risk of Sleep Disorder Among Persons with Mild Traumatic Brain Injury},
author = {Mollayeva, T and Mollayeva, S and Colantonio, A},
year = {2016},
date = {2016-01-01},
journal = {Current Neurology \& Neuroscience Reports},
volume = {16},
number = {6},
pages = {55},
abstract = {Sleep disorders and mild traumatic brain injury (mTBI) are among the most commonly occurring neurological problems clinicians encounter simultaneously. Each can cause the other, and both share common predisposing factors. An important question that remains to be addressed is whether high-risk groups can be defined. We observed an accumulation of considerable knowledge on sleep dysfunction in mTBI in recently published works. The results highlight sleep disturbances in mTBI as the product of diverse internal and external influences, acting on a genetically determined substrate. This may partially explain the clinical heterogeneity of mTBI, pointing to the importance of establishing an accurate history on the onset and course of a specific sleep disorder in the early stages post-mTBI in the individual patient. Such an approach will aid not only diagnosis and treatment but may also lead to identification of disorders whose symptoms mimic those of TBI and thereby direct the most suitable treatment and management.},
keywords = {*Brain Concussion/co [Complications], *Sleep Wake Disorders/et [Etiology], Animals, Brain Concussion/pa [Pathology], Brain/pa [Pathology], Humans, Risk Factors, Sleep Wake Disorders/ge [Genetics], wakefulness},
pubstate = {published},
tppubtype = {article}
}
Underwood, E
NEUROSCIENCE. Can brain scans reveal concussion-linked disease? Journal Article
In: Science, vol. 352, no. 6288, pp. 881, 2016.
BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Injury, *Neuroimaging/mt [Methods], *Positron-Emission Tomography/mt [Methods], *tau Proteins/an [Analysis], 0 (7-(6-fluoropyridin-3-yl)-5H-pyrido(4, 0 (Carbolines), 0 (tau Proteins), 3-b)indole, adult, Carbolines/pk [Pharmacokinetics], Chronic/di [Diagnosis], Chronic/et [Etiology], Humans
@article{Underwood2016,
title = {NEUROSCIENCE. Can brain scans reveal concussion-linked disease?},
author = {Underwood, E},
year = {2016},
date = {2016-01-01},
journal = {Science},
volume = {352},
number = {6288},
pages = {881},
keywords = {*Brain Concussion/co [Complications], *Brain Injury, *Neuroimaging/mt [Methods], *Positron-Emission Tomography/mt [Methods], *tau Proteins/an [Analysis], 0 (7-(6-fluoropyridin-3-yl)-5H-pyrido(4, 0 (Carbolines), 0 (tau Proteins), 3-b)indole, adult, Carbolines/pk [Pharmacokinetics], Chronic/di [Diagnosis], Chronic/et [Etiology], Humans},
pubstate = {published},
tppubtype = {article}
}
Stewart, W; McNamara, P H; Lawlor, B; Hutchinson, S; Farrell, M
Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union? Journal Article
In: Qjm, vol. 109, no. 1, pp. 11–15, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Injury, *Brain/pp [Physiopathology], *Football/in [Injuries], *Neurodegenerative Diseases/pp [Physiopathology], Chronic/pa [Pathology], Humans, Magnetic Resonance Imaging, Male, middle aged, neurologic examination
@article{Stewart2016,
title = {Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union?},
author = {Stewart, W and McNamara, P H and Lawlor, B and Hutchinson, S and Farrell, M},
year = {2016},
date = {2016-01-01},
journal = {Qjm},
volume = {109},
number = {1},
pages = {11--15},
abstract = {The association between exposure to head injury and increased risk of neurodegenerative disease, specifically chronic traumatic encephalopathy (CTE), is widely recognized. Historically, this was largely considered a phenomenon restricted to boxers, with more recent case series identifying further 'high risk' individuals, such as former American footballers, or military personnel. However, in all cases thus far reported, it is clear that it is the exposure to head injury which is associated with increased dementia risk, and not the circumstances or environment of exposure. As such, there is considerable potential for under-recognition of CTE in patients presenting with neurodegenerative disease, particularly where head injury exposure might have been historical and through sport. This article reviews current understanding of CTE and, via an illustrative case in rugby union, highlights the value of a detailed history on head injury and also draws attention to imaging studies in assessing patients with neurodegenerative disease. Copyright © The Author 2015. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com.},
keywords = {*Brain Concussion/co [Complications], *Brain Injury, *Brain/pp [Physiopathology], *Football/in [Injuries], *Neurodegenerative Diseases/pp [Physiopathology], Chronic/pa [Pathology], Humans, Magnetic Resonance Imaging, Male, middle aged, neurologic examination},
pubstate = {published},
tppubtype = {article}
}
Monaco 3rd, E A; Tempel, Z
Concussion related to white matter abnormalities and cognitive dysfunction in aging athletes Journal Article
In: Neurosurgery, vol. 76, no. 4, pp. N10–1, 2015.
BibTeX | Tags: *Athletes, *Brain Concussion/co [Complications], *Cognition Disorders/et [Etiology], *White Matter/pa [Pathology], aging, Brain Concussion/pa [Pathology], Humans, middle aged, Neuropsychological Tests
@article{Monaco3rd2015,
title = {Concussion related to white matter abnormalities and cognitive dysfunction in aging athletes},
author = {{Monaco 3rd}, E A and Tempel, Z},
year = {2015},
date = {2015-01-01},
journal = {Neurosurgery},
volume = {76},
number = {4},
pages = {N10--1},
keywords = {*Athletes, *Brain Concussion/co [Complications], *Cognition Disorders/et [Etiology], *White Matter/pa [Pathology], aging, Brain Concussion/pa [Pathology], Humans, middle aged, Neuropsychological Tests},
pubstate = {published},
tppubtype = {article}
}
Raukar, N; Chao, L
Concussion: a primer for the physician Journal Article
In: Rhode Island Medicine, vol. 98, no. 6, pp. 27–29, 2015.
BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Concussion/pp [Physiopathology], *Brain Concussion/th [Therapy], *Sports Medicine/st [Standards], Alzheimer Disease/ep [Epidemiology], Athletes, Brain/pp [Physiopathology], Humans, Schools
@article{Raukar2015,
title = {Concussion: a primer for the physician},
author = {Raukar, N and Chao, L},
year = {2015},
date = {2015-01-01},
journal = {Rhode Island Medicine},
volume = {98},
number = {6},
pages = {27--29},
keywords = {*Brain Concussion/co [Complications], *Brain Concussion/pp [Physiopathology], *Brain Concussion/th [Therapy], *Sports Medicine/st [Standards], Alzheimer Disease/ep [Epidemiology], Athletes, Brain/pp [Physiopathology], Humans, Schools},
pubstate = {published},
tppubtype = {article}
}
Dretsch, M N; Silverberg, N D; Iverson, G L
Multiple Past Concussions Are Associated with Ongoing Post-Concussive Symptoms but Not Cognitive Impairment in Active-Duty Army Soldiers Journal Article
In: Journal of Neurotrauma, vol. 32, no. 17, pp. 1301–1306, 2015.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Cognition Disorders/di [Diagnosis], *Military Personnel/sn [Statistics & Numerical Dat, *Post-Concussion Syndrome/di [Diagnosis], adult, Brain Concussion/ep [Epidemiology], Cognition Disorders/ep [Epidemiology], Cognition Disorders/et [Etiology], Female, Humans, Male, Post-Concussion Syndrome/ep [Epidemiology], Post-Concussion Syndrome/et [Etiology], United States/ep [Epidemiology], Young Adult
@article{Dretsch2015,
title = {Multiple Past Concussions Are Associated with Ongoing Post-Concussive Symptoms but Not Cognitive Impairment in Active-Duty Army Soldiers},
author = {Dretsch, M N and Silverberg, N D and Iverson, G L},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neurotrauma},
volume = {32},
number = {17},
pages = {1301--1306},
abstract = {The extent to which multiple past concussions are associated with lingering symptoms or mental health problems in military service members is not well understood. The purpose of this study was to examine the association between lifetime concussion history, cognitive functioning, general health, and psychological health in a large sample of fit-for-duty U.S. Army soldiers preparing for deployment. Data on 458 active-duty soldiers were collected and analyzed. A computerized cognitive screening battery (CNS-Vital Signs()) was used to assess complex attention (CA), reaction time (RT), processing speed (PS), cognitive flexibility (CF), and memory. Health questionnaires included the Neurobehavioral Symptom Inventory (NSI), PTSD Checklist-Military Version (PCL-M), Zung Depression and Anxiety Scales (ZDS; ZAS), Perceived Stress Scale (PSS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and the Alcohol Use and Dependency Identification Test (AUDIT). Soldiers with a history of multiple concussions (i.e., three or more concussions) had significantly greater post-concussive symptom scores compared with those with zero (d=1.83, large effect), one (d=0.64, medium effect), and two (d=0.64, medium effect) prior concussions. Although the group with three or more concussions also reported more traumatic stress symptoms, the results revealed that traumatic stress was a mediator between concussions and post-concussive symptom severity. There were no significant differences on neurocognitive testing between the number of concussions. These results add to the accumulating evidence suggesting that most individuals recover from one or two prior concussions, but there is a greater risk for ongoing symptoms if one exceeds this number of injuries.},
keywords = {*Brain Concussion/co [Complications], *Cognition Disorders/di [Diagnosis], *Military Personnel/sn [Statistics \& Numerical Dat, *Post-Concussion Syndrome/di [Diagnosis], adult, Brain Concussion/ep [Epidemiology], Cognition Disorders/ep [Epidemiology], Cognition Disorders/et [Etiology], Female, Humans, Male, Post-Concussion Syndrome/ep [Epidemiology], Post-Concussion Syndrome/et [Etiology], United States/ep [Epidemiology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Thornton, A E; Cox, D N; Whitfield, K; Fouladi, R T
Cumulative concussion exposure in rugby players: neurocognitive and symptomatic outcomes Journal Article
In: Journal of Clinical & Experimental Neuropsychology, vol. 30, no. 4, pp. 398–409, 2008.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *COGNITION, *Cognition Disorders/et [Etiology], *Football/in [Injuries], adult, Age Factors, aged, Brain Concussion/di [Diagnosis], Female, Humans, Male, middle aged, Neuropsychological Tests, Predictive Value of Tests, REGRESSION analysis, Surveys and Questionnaires, Trauma Severity Indices
@article{Thornton2008a,
title = {Cumulative concussion exposure in rugby players: neurocognitive and symptomatic outcomes},
author = {Thornton, A E and Cox, D N and Whitfield, K and Fouladi, R T},
year = {2008},
date = {2008-01-01},
journal = {Journal of Clinical \& Experimental Neuropsychology},
volume = {30},
number = {4},
pages = {398--409},
abstract = {A total of 111 rugby players underwent comprehensive testing to determine the impact of self-reported concussion exposure. Reliable estimates of concussion exposure were associated with an increase in postconcussion symptoms (PCS), but not diminished neurocognitive functioning. Importantly, the effects of concussion exposure on PCS varied as a function of player status. More specifically, extent of concussion exposure was associated with increased memory complaints and overall PCS endorsements in a dose-dependent manner for retired and older recreational players, but not for those who were younger and playing at more competitive levels. Future work should systematically evaluate the constituent participant factors that may influence differential concussion outcomes.},
keywords = {*Brain Concussion/co [Complications], *COGNITION, *Cognition Disorders/et [Etiology], *Football/in [Injuries], adult, Age Factors, aged, Brain Concussion/di [Diagnosis], Female, Humans, Male, middle aged, Neuropsychological Tests, Predictive Value of Tests, REGRESSION analysis, Surveys and Questionnaires, Trauma Severity Indices},
pubstate = {published},
tppubtype = {article}
}