Meier, Timothy B; Bellgowan, Patrick S F; Mayer, Andrew R
Longitudinal assessment of local and global functional connectivity following sports-related concussion Journal Article
In: Brain Imaging & Behavior, 2016, ISBN: 1931-7557.
Abstract | Links | BibTeX | Tags: 2016, fMRI, mild traumatic brain injury, No terms assigned, Regional homogeneity, Resting state
@article{Meier2016c,
title = {Longitudinal assessment of local and global functional connectivity following sports-related concussion},
author = {Meier, Timothy B and Bellgowan, Patrick S F and Mayer, Andrew R},
doi = {10.1007/s11682-016-9520-y},
isbn = {1931-7557},
year = {2016},
date = {2016-01-01},
journal = {Brain Imaging \& Behavior},
publisher = {Springer},
address = {Germany},
abstract = {Growing evidence suggests that sports-related concussions (SRC) may lead to acute changes in intrinsic functional connectivity, although most studies to date have been cross-sectional in nature with relatively modest sample sizes. We longitudinally assessed changes in local and global resting state functional connectivity using metrics that do not require a priori seed or network selection (regional homogeneity; ReHo and global brain connectivity; GBC, respectively). A large sample of collegiate athletes (N = 43) was assessed approximately one day (1.74 days post-injury},
keywords = {2016, fMRI, mild traumatic brain injury, No terms assigned, Regional homogeneity, Resting state},
pubstate = {published},
tppubtype = {article}
}
Sinopoli, Katia J; Chen, Jen-Kai; Wells, Greg; Fait, Philippe; Ptito, Alain; Taha, Tim; Keightley, Michelle
Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance Journal Article
In: Journal of Neurotrauma, vol. 31, no. 22, pp. 1843–1859, 2014, ISBN: 0897-7151 1557-9042.
Abstract | Links | BibTeX | Tags: 2014, Athletes, dual task, Dual Task Performance, fMRI, functional magnetic resonance imaging, mild TBI, short term memory, traumatic brain injury, working memory
@article{Sinopoli2014,
title = {Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance},
author = {Sinopoli, Katia J and Chen, Jen-Kai and Wells, Greg and Fait, Philippe and Ptito, Alain and Taha, Tim and Keightley, Michelle},
doi = {10.1089/neu.2014.3326},
isbn = {0897-7151
1557-9042},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neurotrauma},
volume = {31},
number = {22},
pages = {1843--1859},
publisher = {Mary Ann Liebert, Inc.},
address = {US},
abstract = {Mild traumatic brain injury (mTBI) is a common cause of injury in youth athletes. Much of what is known about the sequelae of mTBI is yielded from the adult literature, and it appears that it is mainly those with persistent post-injury symptoms who have ongoing cognitive and neural abnormalities. However, most studies have employed single-task paradigms, which may not be challenging enough to uncover subtle deficits. We sought to examine the neural correlates of dual-task performance in male athletes aged 9-15 years using a functional neuroimaging protocol. Participants included 13 youths with a history of mTBI three to six months prior to testing and 14 typically-developing controls. All participants completed a working memory task in isolation (single-task) and while completing a concurrent motor task (dual-task); neural activity during performance was then compared between groups. Although working memory performance was similar during the single-task condition, increased working memory load resulted in an altered pattern of neural activation in key working memory areas (i.e., dorsolateral prefrontal and parietal cortices) in youth with mTBI relative to controls. During the dual-task condition, accuracy was similar between groups but injured youth performed slower than typically-developing controls, suggesting a speed-accuracy tradeoff in the mTBI group only. The injured youths also exhibited abnormal recruitment of brain structures involved in both working memory and dual-tasking. These data show that the dual-task paradigm can uncover functional impairments in youth with mTBI who are not highly symptomatic and who do not exhibit neuropsychological dysfunction. Moreover, neural recruitment abnormalities were noted in both task conditions, which we argue suggests mTBI-related disruptions in achieving efficient cognitive control and allocation of processing resources. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2014, Athletes, dual task, Dual Task Performance, fMRI, functional magnetic resonance imaging, mild TBI, short term memory, traumatic brain injury, working memory},
pubstate = {published},
tppubtype = {article}
}
Meier, Timothy B; Bellgowan, Patrick S F; Mayer, Andrew R
Longitudinal assessment of local and global functional connectivity following sports-related concussion Journal Article
In: Brain Imaging & Behavior, 2016, ISBN: 1931-7557.
@article{Meier2016c,
title = {Longitudinal assessment of local and global functional connectivity following sports-related concussion},
author = {Meier, Timothy B and Bellgowan, Patrick S F and Mayer, Andrew R},
doi = {10.1007/s11682-016-9520-y},
isbn = {1931-7557},
year = {2016},
date = {2016-01-01},
journal = {Brain Imaging \& Behavior},
publisher = {Springer},
address = {Germany},
abstract = {Growing evidence suggests that sports-related concussions (SRC) may lead to acute changes in intrinsic functional connectivity, although most studies to date have been cross-sectional in nature with relatively modest sample sizes. We longitudinally assessed changes in local and global resting state functional connectivity using metrics that do not require a priori seed or network selection (regional homogeneity; ReHo and global brain connectivity; GBC, respectively). A large sample of collegiate athletes (N = 43) was assessed approximately one day (1.74 days post-injury},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sinopoli, Katia J; Chen, Jen-Kai; Wells, Greg; Fait, Philippe; Ptito, Alain; Taha, Tim; Keightley, Michelle
Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance Journal Article
In: Journal of Neurotrauma, vol. 31, no. 22, pp. 1843–1859, 2014, ISBN: 0897-7151 1557-9042.
@article{Sinopoli2014,
title = {Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance},
author = {Sinopoli, Katia J and Chen, Jen-Kai and Wells, Greg and Fait, Philippe and Ptito, Alain and Taha, Tim and Keightley, Michelle},
doi = {10.1089/neu.2014.3326},
isbn = {0897-7151
1557-9042},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neurotrauma},
volume = {31},
number = {22},
pages = {1843--1859},
publisher = {Mary Ann Liebert, Inc.},
address = {US},
abstract = {Mild traumatic brain injury (mTBI) is a common cause of injury in youth athletes. Much of what is known about the sequelae of mTBI is yielded from the adult literature, and it appears that it is mainly those with persistent post-injury symptoms who have ongoing cognitive and neural abnormalities. However, most studies have employed single-task paradigms, which may not be challenging enough to uncover subtle deficits. We sought to examine the neural correlates of dual-task performance in male athletes aged 9-15 years using a functional neuroimaging protocol. Participants included 13 youths with a history of mTBI three to six months prior to testing and 14 typically-developing controls. All participants completed a working memory task in isolation (single-task) and while completing a concurrent motor task (dual-task); neural activity during performance was then compared between groups. Although working memory performance was similar during the single-task condition, increased working memory load resulted in an altered pattern of neural activation in key working memory areas (i.e., dorsolateral prefrontal and parietal cortices) in youth with mTBI relative to controls. During the dual-task condition, accuracy was similar between groups but injured youth performed slower than typically-developing controls, suggesting a speed-accuracy tradeoff in the mTBI group only. The injured youths also exhibited abnormal recruitment of brain structures involved in both working memory and dual-tasking. These data show that the dual-task paradigm can uncover functional impairments in youth with mTBI who are not highly symptomatic and who do not exhibit neuropsychological dysfunction. Moreover, neural recruitment abnormalities were noted in both task conditions, which we argue suggests mTBI-related disruptions in achieving efficient cognitive control and allocation of processing resources. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Meier, Timothy B; Bellgowan, Patrick S F; Mayer, Andrew R
Longitudinal assessment of local and global functional connectivity following sports-related concussion Journal Article
In: Brain Imaging & Behavior, 2016, ISBN: 1931-7557.
Abstract | Links | BibTeX | Tags: 2016, fMRI, mild traumatic brain injury, No terms assigned, Regional homogeneity, Resting state
@article{Meier2016c,
title = {Longitudinal assessment of local and global functional connectivity following sports-related concussion},
author = {Meier, Timothy B and Bellgowan, Patrick S F and Mayer, Andrew R},
doi = {10.1007/s11682-016-9520-y},
isbn = {1931-7557},
year = {2016},
date = {2016-01-01},
journal = {Brain Imaging \& Behavior},
publisher = {Springer},
address = {Germany},
abstract = {Growing evidence suggests that sports-related concussions (SRC) may lead to acute changes in intrinsic functional connectivity, although most studies to date have been cross-sectional in nature with relatively modest sample sizes. We longitudinally assessed changes in local and global resting state functional connectivity using metrics that do not require a priori seed or network selection (regional homogeneity; ReHo and global brain connectivity; GBC, respectively). A large sample of collegiate athletes (N = 43) was assessed approximately one day (1.74 days post-injury},
keywords = {2016, fMRI, mild traumatic brain injury, No terms assigned, Regional homogeneity, Resting state},
pubstate = {published},
tppubtype = {article}
}
Sinopoli, Katia J; Chen, Jen-Kai; Wells, Greg; Fait, Philippe; Ptito, Alain; Taha, Tim; Keightley, Michelle
Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance Journal Article
In: Journal of Neurotrauma, vol. 31, no. 22, pp. 1843–1859, 2014, ISBN: 0897-7151 1557-9042.
Abstract | Links | BibTeX | Tags: 2014, Athletes, dual task, Dual Task Performance, fMRI, functional magnetic resonance imaging, mild TBI, short term memory, traumatic brain injury, working memory
@article{Sinopoli2014,
title = {Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance},
author = {Sinopoli, Katia J and Chen, Jen-Kai and Wells, Greg and Fait, Philippe and Ptito, Alain and Taha, Tim and Keightley, Michelle},
doi = {10.1089/neu.2014.3326},
isbn = {0897-7151
1557-9042},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neurotrauma},
volume = {31},
number = {22},
pages = {1843--1859},
publisher = {Mary Ann Liebert, Inc.},
address = {US},
abstract = {Mild traumatic brain injury (mTBI) is a common cause of injury in youth athletes. Much of what is known about the sequelae of mTBI is yielded from the adult literature, and it appears that it is mainly those with persistent post-injury symptoms who have ongoing cognitive and neural abnormalities. However, most studies have employed single-task paradigms, which may not be challenging enough to uncover subtle deficits. We sought to examine the neural correlates of dual-task performance in male athletes aged 9-15 years using a functional neuroimaging protocol. Participants included 13 youths with a history of mTBI three to six months prior to testing and 14 typically-developing controls. All participants completed a working memory task in isolation (single-task) and while completing a concurrent motor task (dual-task); neural activity during performance was then compared between groups. Although working memory performance was similar during the single-task condition, increased working memory load resulted in an altered pattern of neural activation in key working memory areas (i.e., dorsolateral prefrontal and parietal cortices) in youth with mTBI relative to controls. During the dual-task condition, accuracy was similar between groups but injured youth performed slower than typically-developing controls, suggesting a speed-accuracy tradeoff in the mTBI group only. The injured youths also exhibited abnormal recruitment of brain structures involved in both working memory and dual-tasking. These data show that the dual-task paradigm can uncover functional impairments in youth with mTBI who are not highly symptomatic and who do not exhibit neuropsychological dysfunction. Moreover, neural recruitment abnormalities were noted in both task conditions, which we argue suggests mTBI-related disruptions in achieving efficient cognitive control and allocation of processing resources. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2014, Athletes, dual task, Dual Task Performance, fMRI, functional magnetic resonance imaging, mild TBI, short term memory, traumatic brain injury, working memory},
pubstate = {published},
tppubtype = {article}
}