Ling, H; Kara, E; Revesz, T; Lees, A J; Plant, G T; Martino, D; Houlden, H; Hardy, J; Holton, J L
Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer Journal Article
In: Acta neuropathologica communications, vol. 2, pp. 24, 2014.
Abstract | Links | BibTeX | Tags: aged, Brain Injury, case report, Chronic, Chronic Traumatic Encephalopathy GRN protein, complication, genetics, huma, human, Humans, Intercellular Signaling Peptides and Proteins, LRRK2 protein, Male, MAPT protein, pathology, Progressive, progressive supranuclear palsy, protein serine threonine kinase, Protein-Serine-Threonine Kinases, signal peptide, Supranuclear Palsy, tau protein, tau Proteins
@article{Ling2014,
title = {Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer},
author = {Ling, H and Kara, E and Revesz, T and Lees, A J and Plant, G T and Martino, D and Houlden, H and Hardy, J and Holton, J L},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84921282712\&partnerID=40\&md5=ff0c2f58ec97372861b423eb0aa0d6c0},
doi = {10.1186/2051-5960-2-24},
year = {2014},
date = {2014-01-01},
journal = {Acta neuropathologica communications},
volume = {2},
pages = {24},
abstract = {We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed.},
keywords = {aged, Brain Injury, case report, Chronic, Chronic Traumatic Encephalopathy GRN protein, complication, genetics, huma, human, Humans, Intercellular Signaling Peptides and Proteins, LRRK2 protein, Male, MAPT protein, pathology, Progressive, progressive supranuclear palsy, protein serine threonine kinase, Protein-Serine-Threonine Kinases, signal peptide, Supranuclear Palsy, tau protein, tau Proteins},
pubstate = {published},
tppubtype = {article}
}
Gandy, S; DeKosky, S T
[18F]-T807 tauopathy PET imaging in chronic traumatic encephalopathy Journal Article
In: F1000Research, vol. 3, 2014.
Abstract | Links | BibTeX | Tags: aging, Article, athlete, brain region, Chronic Traumatic Encephalopathy radiopharmaceutic, comorbidity, cumulative trauma disorder, diagnostic value, disease association, disease severity, human, image analysis, ligand binding, neurofibrillary tangle, positron emission tomography, progressive supranuclear palsy, t 807 f 18, tauopathy, temporal lobe, traumatic brain injury, unclassified drug, veteran
@article{Gandy2014,
title = {[18F]-T807 tauopathy PET imaging in chronic traumatic encephalopathy},
author = {Gandy, S and DeKosky, S T},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84923165667\&partnerID=40\&md5=90ae38a9d3536705acb61b5e1fbbc81a},
doi = {10.12688/f1000research.5372.1},
year = {2014},
date = {2014-01-01},
journal = {F1000Research},
volume = {3},
abstract = {A new molecular ligand for positron emission tomography (PET) of the human brain, [18F]-T807, is under investigation for the antemortem detection of pathological neurofibrillary aggregates, which are evidence of neurofibrillary tangle (NFT) diseases, also known as tauopathies. Repetitive mild traumatic brain injuries in athletes and battlefield veterans are associated with one such tauopathy, known as chronic traumatic encephalopathy (CTE). In a recent case report, a former NFL player with clinically probable CTE and a concurrent Progressive Supranuclear Palsy (PSP) -like syndrome was studied using [18F]-T807. The interpretation of this player's [18F]-T807 PET imaging was complicated by the overlap of tracer uptake in brain regions involved in CTE and PSP with regions associated with either nonspecific [18F]-T807 ligand binding or "aging-associated" binding of [18F]-T807 to authentic tauopathy known to be associated with aging and disease severity (i.e., NFT in the mesial temporal lobe). The implications of these data for the utility of [18F]-T807 in the pre-mortem detection of CTE are summarized. © 2014 Gandy S and DeKosky ST.},
keywords = {aging, Article, athlete, brain region, Chronic Traumatic Encephalopathy radiopharmaceutic, comorbidity, cumulative trauma disorder, diagnostic value, disease association, disease severity, human, image analysis, ligand binding, neurofibrillary tangle, positron emission tomography, progressive supranuclear palsy, t 807 f 18, tauopathy, temporal lobe, traumatic brain injury, unclassified drug, veteran},
pubstate = {published},
tppubtype = {article}
}
Ling, H; Kara, E; Revesz, T; Lees, A J; Plant, G T; Martino, D; Houlden, H; Hardy, J; Holton, J L
Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer Journal Article
In: Acta neuropathologica communications, vol. 2, pp. 24, 2014.
@article{Ling2014,
title = {Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer},
author = {Ling, H and Kara, E and Revesz, T and Lees, A J and Plant, G T and Martino, D and Houlden, H and Hardy, J and Holton, J L},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84921282712\&partnerID=40\&md5=ff0c2f58ec97372861b423eb0aa0d6c0},
doi = {10.1186/2051-5960-2-24},
year = {2014},
date = {2014-01-01},
journal = {Acta neuropathologica communications},
volume = {2},
pages = {24},
abstract = {We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gandy, S; DeKosky, S T
[18F]-T807 tauopathy PET imaging in chronic traumatic encephalopathy Journal Article
In: F1000Research, vol. 3, 2014.
@article{Gandy2014,
title = {[18F]-T807 tauopathy PET imaging in chronic traumatic encephalopathy},
author = {Gandy, S and DeKosky, S T},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84923165667\&partnerID=40\&md5=90ae38a9d3536705acb61b5e1fbbc81a},
doi = {10.12688/f1000research.5372.1},
year = {2014},
date = {2014-01-01},
journal = {F1000Research},
volume = {3},
abstract = {A new molecular ligand for positron emission tomography (PET) of the human brain, [18F]-T807, is under investigation for the antemortem detection of pathological neurofibrillary aggregates, which are evidence of neurofibrillary tangle (NFT) diseases, also known as tauopathies. Repetitive mild traumatic brain injuries in athletes and battlefield veterans are associated with one such tauopathy, known as chronic traumatic encephalopathy (CTE). In a recent case report, a former NFL player with clinically probable CTE and a concurrent Progressive Supranuclear Palsy (PSP) -like syndrome was studied using [18F]-T807. The interpretation of this player's [18F]-T807 PET imaging was complicated by the overlap of tracer uptake in brain regions involved in CTE and PSP with regions associated with either nonspecific [18F]-T807 ligand binding or "aging-associated" binding of [18F]-T807 to authentic tauopathy known to be associated with aging and disease severity (i.e., NFT in the mesial temporal lobe). The implications of these data for the utility of [18F]-T807 in the pre-mortem detection of CTE are summarized. © 2014 Gandy S and DeKosky ST.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ling, H; Kara, E; Revesz, T; Lees, A J; Plant, G T; Martino, D; Houlden, H; Hardy, J; Holton, J L
Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer Journal Article
In: Acta neuropathologica communications, vol. 2, pp. 24, 2014.
Abstract | Links | BibTeX | Tags: aged, Brain Injury, case report, Chronic, Chronic Traumatic Encephalopathy GRN protein, complication, genetics, huma, human, Humans, Intercellular Signaling Peptides and Proteins, LRRK2 protein, Male, MAPT protein, pathology, Progressive, progressive supranuclear palsy, protein serine threonine kinase, Protein-Serine-Threonine Kinases, signal peptide, Supranuclear Palsy, tau protein, tau Proteins
@article{Ling2014,
title = {Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer},
author = {Ling, H and Kara, E and Revesz, T and Lees, A J and Plant, G T and Martino, D and Houlden, H and Hardy, J and Holton, J L},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84921282712\&partnerID=40\&md5=ff0c2f58ec97372861b423eb0aa0d6c0},
doi = {10.1186/2051-5960-2-24},
year = {2014},
date = {2014-01-01},
journal = {Acta neuropathologica communications},
volume = {2},
pages = {24},
abstract = {We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed.},
keywords = {aged, Brain Injury, case report, Chronic, Chronic Traumatic Encephalopathy GRN protein, complication, genetics, huma, human, Humans, Intercellular Signaling Peptides and Proteins, LRRK2 protein, Male, MAPT protein, pathology, Progressive, progressive supranuclear palsy, protein serine threonine kinase, Protein-Serine-Threonine Kinases, signal peptide, Supranuclear Palsy, tau protein, tau Proteins},
pubstate = {published},
tppubtype = {article}
}
Gandy, S; DeKosky, S T
[18F]-T807 tauopathy PET imaging in chronic traumatic encephalopathy Journal Article
In: F1000Research, vol. 3, 2014.
Abstract | Links | BibTeX | Tags: aging, Article, athlete, brain region, Chronic Traumatic Encephalopathy radiopharmaceutic, comorbidity, cumulative trauma disorder, diagnostic value, disease association, disease severity, human, image analysis, ligand binding, neurofibrillary tangle, positron emission tomography, progressive supranuclear palsy, t 807 f 18, tauopathy, temporal lobe, traumatic brain injury, unclassified drug, veteran
@article{Gandy2014,
title = {[18F]-T807 tauopathy PET imaging in chronic traumatic encephalopathy},
author = {Gandy, S and DeKosky, S T},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84923165667\&partnerID=40\&md5=90ae38a9d3536705acb61b5e1fbbc81a},
doi = {10.12688/f1000research.5372.1},
year = {2014},
date = {2014-01-01},
journal = {F1000Research},
volume = {3},
abstract = {A new molecular ligand for positron emission tomography (PET) of the human brain, [18F]-T807, is under investigation for the antemortem detection of pathological neurofibrillary aggregates, which are evidence of neurofibrillary tangle (NFT) diseases, also known as tauopathies. Repetitive mild traumatic brain injuries in athletes and battlefield veterans are associated with one such tauopathy, known as chronic traumatic encephalopathy (CTE). In a recent case report, a former NFL player with clinically probable CTE and a concurrent Progressive Supranuclear Palsy (PSP) -like syndrome was studied using [18F]-T807. The interpretation of this player's [18F]-T807 PET imaging was complicated by the overlap of tracer uptake in brain regions involved in CTE and PSP with regions associated with either nonspecific [18F]-T807 ligand binding or "aging-associated" binding of [18F]-T807 to authentic tauopathy known to be associated with aging and disease severity (i.e., NFT in the mesial temporal lobe). The implications of these data for the utility of [18F]-T807 in the pre-mortem detection of CTE are summarized. © 2014 Gandy S and DeKosky ST.},
keywords = {aging, Article, athlete, brain region, Chronic Traumatic Encephalopathy radiopharmaceutic, comorbidity, cumulative trauma disorder, diagnostic value, disease association, disease severity, human, image analysis, ligand binding, neurofibrillary tangle, positron emission tomography, progressive supranuclear palsy, t 807 f 18, tauopathy, temporal lobe, traumatic brain injury, unclassified drug, veteran},
pubstate = {published},
tppubtype = {article}
}