Grafman, J; Salazar, A M
The ebb and flow of traumatic brain injury research Journal Article
In: Handbook of Clinical Neurology, vol. 128, pp. 795–802, 2015.
Abstract | BibTeX | Tags: *Biomedical Research/mt [Methods], *Biomedical Research/td [Trends], *Brain Injuries/th [Therapy], Animals, Humans
@article{Grafman2015,
title = {The ebb and flow of traumatic brain injury research},
author = {Grafman, J and Salazar, A M},
year = {2015},
date = {2015-01-01},
journal = {Handbook of Clinical Neurology},
volume = {128},
pages = {795--802},
abstract = {The purpose of this chapter is to summarize some key topics discussed in this volume and describe trends suggesting the direction of future traumatic brain injury (TBI) research. Interest in, and funding for, TBI has ebbed and flowed with the public awareness of injury risk from combat, sports, or everyday life. Advances in acute resuscitation, emergency response systems, and early management have had a major impact on survival after TBI, while recent research has emphasized underlying genetic substrates and the molecular mechanisms of brain injury, repair, and neuroplasticity. This in turn impacts not only on primary and secondary neuroprotection strategies for minimizing injury, but also on the other critical remaining challenge, that of identification and validation of optimal strategies for physical and cognitive TBI rehabilitation. New information also highlights long-term degenerative conditions associated with earlier TBI and mediated by a signature cascade of abnormal molecular processes. Thus, TBI has emerged as a recognized significant public health risk with both immediate and lifelong repercussions. The linkage of a TBI to late-life neurodegenerative diseases, the observation of persistent pathologic processes including neuroinflammation and accumulation of tau protein, as well as individual differences in the genetic predisposition for brain repair and plasticity should lead to meaningful translational research with a significant impact on the efficacy and cost-efficiency of acute and chronic treatment for TBI survivors. Copyright © 2015 Elsevier B.V. All rights reserved.},
keywords = {*Biomedical Research/mt [Methods], *Biomedical Research/td [Trends], *Brain Injuries/th [Therapy], Animals, Humans},
pubstate = {published},
tppubtype = {article}
}
Hooper, S R; Ornitz, C; White, J K; Lash, M; Newlin, E; Makor, L; Farmer, S
Traumatic brain injury in North Carolina: the state of the state today Journal Article
In: North Carolina Medical Journal, vol. 76, no. 2, pp. 84–88, 2015.
Abstract | BibTeX | Tags: *Brain Injuries/ep [Epidemiology], *Brain Injuries/th [Therapy], *Health Services Needs and Demand, *Public Policy, Humans, North Carolina/ep [Epidemiology]
@article{Hooper2015,
title = {Traumatic brain injury in North Carolina: the state of the state today},
author = {Hooper, S R and Ornitz, C and White, J K and Lash, M and Newlin, E and Makor, L and Farmer, S},
year = {2015},
date = {2015-01-01},
journal = {North Carolina Medical Journal},
volume = {76},
number = {2},
pages = {84--88},
abstract = {This issue brief provides an overview of the "state of the state" for traumatic brain injury (TBI) issues and challenges in North Carolina. A previous issue of the North Carolina Medical Journal discussed this topic approximately 14 years ago, and this issue brief showcases changes and advances since that time. Collectively, articles in the current issue highlight the current epidemiology of TBI; the rapidly advancing and critical topic of concussions; special populations where TBI is seen more frequently, such as elderly individuals and veterans; advances in TBI-related treatments; and the all-important family perspective on TBI. Additionally, this issue brief discusses key developments and advances in the state related to a statewide needs assessment; legislative and policy actions, including a new sports concussion awareness act and a significantly revised definition of TBI as it relates to special education classification; and ongoing exploration of evidence-based community services that have the potential to improve our system of care for adults with TBI. Finally, ongoing challenges are detailed with the intention of pushing the state to become one of the nation's leaders in TBI services.},
keywords = {*Brain Injuries/ep [Epidemiology], *Brain Injuries/th [Therapy], *Health Services Needs and Demand, *Public Policy, Humans, North Carolina/ep [Epidemiology]},
pubstate = {published},
tppubtype = {article}
}
Grafman, J; Salazar, A M
The ebb and flow of traumatic brain injury research Journal Article
In: Handbook of Clinical Neurology, vol. 128, pp. 795–802, 2015.
@article{Grafman2015,
title = {The ebb and flow of traumatic brain injury research},
author = {Grafman, J and Salazar, A M},
year = {2015},
date = {2015-01-01},
journal = {Handbook of Clinical Neurology},
volume = {128},
pages = {795--802},
abstract = {The purpose of this chapter is to summarize some key topics discussed in this volume and describe trends suggesting the direction of future traumatic brain injury (TBI) research. Interest in, and funding for, TBI has ebbed and flowed with the public awareness of injury risk from combat, sports, or everyday life. Advances in acute resuscitation, emergency response systems, and early management have had a major impact on survival after TBI, while recent research has emphasized underlying genetic substrates and the molecular mechanisms of brain injury, repair, and neuroplasticity. This in turn impacts not only on primary and secondary neuroprotection strategies for minimizing injury, but also on the other critical remaining challenge, that of identification and validation of optimal strategies for physical and cognitive TBI rehabilitation. New information also highlights long-term degenerative conditions associated with earlier TBI and mediated by a signature cascade of abnormal molecular processes. Thus, TBI has emerged as a recognized significant public health risk with both immediate and lifelong repercussions. The linkage of a TBI to late-life neurodegenerative diseases, the observation of persistent pathologic processes including neuroinflammation and accumulation of tau protein, as well as individual differences in the genetic predisposition for brain repair and plasticity should lead to meaningful translational research with a significant impact on the efficacy and cost-efficiency of acute and chronic treatment for TBI survivors. Copyright © 2015 Elsevier B.V. All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Hooper, S R; Ornitz, C; White, J K; Lash, M; Newlin, E; Makor, L; Farmer, S
Traumatic brain injury in North Carolina: the state of the state today Journal Article
In: North Carolina Medical Journal, vol. 76, no. 2, pp. 84–88, 2015.
@article{Hooper2015,
title = {Traumatic brain injury in North Carolina: the state of the state today},
author = {Hooper, S R and Ornitz, C and White, J K and Lash, M and Newlin, E and Makor, L and Farmer, S},
year = {2015},
date = {2015-01-01},
journal = {North Carolina Medical Journal},
volume = {76},
number = {2},
pages = {84--88},
abstract = {This issue brief provides an overview of the "state of the state" for traumatic brain injury (TBI) issues and challenges in North Carolina. A previous issue of the North Carolina Medical Journal discussed this topic approximately 14 years ago, and this issue brief showcases changes and advances since that time. Collectively, articles in the current issue highlight the current epidemiology of TBI; the rapidly advancing and critical topic of concussions; special populations where TBI is seen more frequently, such as elderly individuals and veterans; advances in TBI-related treatments; and the all-important family perspective on TBI. Additionally, this issue brief discusses key developments and advances in the state related to a statewide needs assessment; legislative and policy actions, including a new sports concussion awareness act and a significantly revised definition of TBI as it relates to special education classification; and ongoing exploration of evidence-based community services that have the potential to improve our system of care for adults with TBI. Finally, ongoing challenges are detailed with the intention of pushing the state to become one of the nation's leaders in TBI services.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Grafman, J; Salazar, A M
The ebb and flow of traumatic brain injury research Journal Article
In: Handbook of Clinical Neurology, vol. 128, pp. 795–802, 2015.
Abstract | BibTeX | Tags: *Biomedical Research/mt [Methods], *Biomedical Research/td [Trends], *Brain Injuries/th [Therapy], Animals, Humans
@article{Grafman2015,
title = {The ebb and flow of traumatic brain injury research},
author = {Grafman, J and Salazar, A M},
year = {2015},
date = {2015-01-01},
journal = {Handbook of Clinical Neurology},
volume = {128},
pages = {795--802},
abstract = {The purpose of this chapter is to summarize some key topics discussed in this volume and describe trends suggesting the direction of future traumatic brain injury (TBI) research. Interest in, and funding for, TBI has ebbed and flowed with the public awareness of injury risk from combat, sports, or everyday life. Advances in acute resuscitation, emergency response systems, and early management have had a major impact on survival after TBI, while recent research has emphasized underlying genetic substrates and the molecular mechanisms of brain injury, repair, and neuroplasticity. This in turn impacts not only on primary and secondary neuroprotection strategies for minimizing injury, but also on the other critical remaining challenge, that of identification and validation of optimal strategies for physical and cognitive TBI rehabilitation. New information also highlights long-term degenerative conditions associated with earlier TBI and mediated by a signature cascade of abnormal molecular processes. Thus, TBI has emerged as a recognized significant public health risk with both immediate and lifelong repercussions. The linkage of a TBI to late-life neurodegenerative diseases, the observation of persistent pathologic processes including neuroinflammation and accumulation of tau protein, as well as individual differences in the genetic predisposition for brain repair and plasticity should lead to meaningful translational research with a significant impact on the efficacy and cost-efficiency of acute and chronic treatment for TBI survivors. Copyright © 2015 Elsevier B.V. All rights reserved.},
keywords = {*Biomedical Research/mt [Methods], *Biomedical Research/td [Trends], *Brain Injuries/th [Therapy], Animals, Humans},
pubstate = {published},
tppubtype = {article}
}
Hooper, S R; Ornitz, C; White, J K; Lash, M; Newlin, E; Makor, L; Farmer, S
Traumatic brain injury in North Carolina: the state of the state today Journal Article
In: North Carolina Medical Journal, vol. 76, no. 2, pp. 84–88, 2015.
Abstract | BibTeX | Tags: *Brain Injuries/ep [Epidemiology], *Brain Injuries/th [Therapy], *Health Services Needs and Demand, *Public Policy, Humans, North Carolina/ep [Epidemiology]
@article{Hooper2015,
title = {Traumatic brain injury in North Carolina: the state of the state today},
author = {Hooper, S R and Ornitz, C and White, J K and Lash, M and Newlin, E and Makor, L and Farmer, S},
year = {2015},
date = {2015-01-01},
journal = {North Carolina Medical Journal},
volume = {76},
number = {2},
pages = {84--88},
abstract = {This issue brief provides an overview of the "state of the state" for traumatic brain injury (TBI) issues and challenges in North Carolina. A previous issue of the North Carolina Medical Journal discussed this topic approximately 14 years ago, and this issue brief showcases changes and advances since that time. Collectively, articles in the current issue highlight the current epidemiology of TBI; the rapidly advancing and critical topic of concussions; special populations where TBI is seen more frequently, such as elderly individuals and veterans; advances in TBI-related treatments; and the all-important family perspective on TBI. Additionally, this issue brief discusses key developments and advances in the state related to a statewide needs assessment; legislative and policy actions, including a new sports concussion awareness act and a significantly revised definition of TBI as it relates to special education classification; and ongoing exploration of evidence-based community services that have the potential to improve our system of care for adults with TBI. Finally, ongoing challenges are detailed with the intention of pushing the state to become one of the nation's leaders in TBI services.},
keywords = {*Brain Injuries/ep [Epidemiology], *Brain Injuries/th [Therapy], *Health Services Needs and Demand, *Public Policy, Humans, North Carolina/ep [Epidemiology]},
pubstate = {published},
tppubtype = {article}
}