Bigler, Erin D; Deibert, Ellen
Lesion analysis in mild traumatic brain injury: Old school goes high tech Journal Article
In: Neurology, vol. 83, no. 14, pp. 1226–1227, 2014, ISBN: 0028-3878 1526-632X.
Abstract | Links | BibTeX | Tags: 2014, ALGORITHMS, brain, functional magnetic resonance imaging, gray matter, mild traumatic brain injury, MRI, traumatic brain injury, white matter
@article{Bigler2014,
title = {Lesion analysis in mild traumatic brain injury: Old school goes high tech},
author = {Bigler, Erin D and Deibert, Ellen},
doi = {10.1212/WNL.0000000000000848},
isbn = {0028-3878
1526-632X},
year = {2014},
date = {2014-01-01},
journal = {Neurology},
volume = {83},
number = {14},
pages = {1226--1227},
publisher = {Lippincott Williams \& Wilkins},
address = {US},
abstract = {Comments on an article by Y. W. Lui et al. (see record [rid]2014-43480-004[/rid]). Concussion has been a controversial topic in neurology since the beginning of the discipline. Evidence based diagnostic guidelines have been established,1 but the diagnosis and treatment are largely grounded in clinical decision-making. Clinical and research issues around sports concussion have even reached the levels of government policy with the White House. At the moderate to severe range of traumatic brain injury, neuroimaging provides well-established, objective pathoanatomical biomarkers of the injury. In contrast, conventional neuroimaging findings in mTBI are typically absent. The cognitive and neurobehavioral symptoms of mTBI overlap with any number of neurologic or psychiatric disorders, providing no definitive marker of injury or for tracking injury effects. Reliable biomarkers of mTBI could lead to better clinical decision-making and potential treatments. Deformation-based biomechanical studies of mTBI have shown the thalamus is situated in a particularly vulnerable zone. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2014, ALGORITHMS, brain, functional magnetic resonance imaging, gray matter, mild traumatic brain injury, MRI, traumatic brain injury, white matter},
pubstate = {published},
tppubtype = {article}
}
Sinopoli, Katia J; Chen, Jen-Kai; Wells, Greg; Fait, Philippe; Ptito, Alain; Taha, Tim; Keightley, Michelle
Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance Journal Article
In: Journal of Neurotrauma, vol. 31, no. 22, pp. 1843–1859, 2014, ISBN: 0897-7151 1557-9042.
Abstract | Links | BibTeX | Tags: 2014, Athletes, dual task, Dual Task Performance, fMRI, functional magnetic resonance imaging, mild TBI, short term memory, traumatic brain injury, working memory
@article{Sinopoli2014,
title = {Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance},
author = {Sinopoli, Katia J and Chen, Jen-Kai and Wells, Greg and Fait, Philippe and Ptito, Alain and Taha, Tim and Keightley, Michelle},
doi = {10.1089/neu.2014.3326},
isbn = {0897-7151
1557-9042},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neurotrauma},
volume = {31},
number = {22},
pages = {1843--1859},
publisher = {Mary Ann Liebert, Inc.},
address = {US},
abstract = {Mild traumatic brain injury (mTBI) is a common cause of injury in youth athletes. Much of what is known about the sequelae of mTBI is yielded from the adult literature, and it appears that it is mainly those with persistent post-injury symptoms who have ongoing cognitive and neural abnormalities. However, most studies have employed single-task paradigms, which may not be challenging enough to uncover subtle deficits. We sought to examine the neural correlates of dual-task performance in male athletes aged 9-15 years using a functional neuroimaging protocol. Participants included 13 youths with a history of mTBI three to six months prior to testing and 14 typically-developing controls. All participants completed a working memory task in isolation (single-task) and while completing a concurrent motor task (dual-task); neural activity during performance was then compared between groups. Although working memory performance was similar during the single-task condition, increased working memory load resulted in an altered pattern of neural activation in key working memory areas (i.e., dorsolateral prefrontal and parietal cortices) in youth with mTBI relative to controls. During the dual-task condition, accuracy was similar between groups but injured youth performed slower than typically-developing controls, suggesting a speed-accuracy tradeoff in the mTBI group only. The injured youths also exhibited abnormal recruitment of brain structures involved in both working memory and dual-tasking. These data show that the dual-task paradigm can uncover functional impairments in youth with mTBI who are not highly symptomatic and who do not exhibit neuropsychological dysfunction. Moreover, neural recruitment abnormalities were noted in both task conditions, which we argue suggests mTBI-related disruptions in achieving efficient cognitive control and allocation of processing resources. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2014, Athletes, dual task, Dual Task Performance, fMRI, functional magnetic resonance imaging, mild TBI, short term memory, traumatic brain injury, working memory},
pubstate = {published},
tppubtype = {article}
}
Bigler, Erin D; Deibert, Ellen
Lesion analysis in mild traumatic brain injury: Old school goes high tech Journal Article
In: Neurology, vol. 83, no. 14, pp. 1226–1227, 2014, ISBN: 0028-3878 1526-632X.
@article{Bigler2014,
title = {Lesion analysis in mild traumatic brain injury: Old school goes high tech},
author = {Bigler, Erin D and Deibert, Ellen},
doi = {10.1212/WNL.0000000000000848},
isbn = {0028-3878
1526-632X},
year = {2014},
date = {2014-01-01},
journal = {Neurology},
volume = {83},
number = {14},
pages = {1226--1227},
publisher = {Lippincott Williams \& Wilkins},
address = {US},
abstract = {Comments on an article by Y. W. Lui et al. (see record [rid]2014-43480-004[/rid]). Concussion has been a controversial topic in neurology since the beginning of the discipline. Evidence based diagnostic guidelines have been established,1 but the diagnosis and treatment are largely grounded in clinical decision-making. Clinical and research issues around sports concussion have even reached the levels of government policy with the White House. At the moderate to severe range of traumatic brain injury, neuroimaging provides well-established, objective pathoanatomical biomarkers of the injury. In contrast, conventional neuroimaging findings in mTBI are typically absent. The cognitive and neurobehavioral symptoms of mTBI overlap with any number of neurologic or psychiatric disorders, providing no definitive marker of injury or for tracking injury effects. Reliable biomarkers of mTBI could lead to better clinical decision-making and potential treatments. Deformation-based biomechanical studies of mTBI have shown the thalamus is situated in a particularly vulnerable zone. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sinopoli, Katia J; Chen, Jen-Kai; Wells, Greg; Fait, Philippe; Ptito, Alain; Taha, Tim; Keightley, Michelle
Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance Journal Article
In: Journal of Neurotrauma, vol. 31, no. 22, pp. 1843–1859, 2014, ISBN: 0897-7151 1557-9042.
@article{Sinopoli2014,
title = {Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance},
author = {Sinopoli, Katia J and Chen, Jen-Kai and Wells, Greg and Fait, Philippe and Ptito, Alain and Taha, Tim and Keightley, Michelle},
doi = {10.1089/neu.2014.3326},
isbn = {0897-7151
1557-9042},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neurotrauma},
volume = {31},
number = {22},
pages = {1843--1859},
publisher = {Mary Ann Liebert, Inc.},
address = {US},
abstract = {Mild traumatic brain injury (mTBI) is a common cause of injury in youth athletes. Much of what is known about the sequelae of mTBI is yielded from the adult literature, and it appears that it is mainly those with persistent post-injury symptoms who have ongoing cognitive and neural abnormalities. However, most studies have employed single-task paradigms, which may not be challenging enough to uncover subtle deficits. We sought to examine the neural correlates of dual-task performance in male athletes aged 9-15 years using a functional neuroimaging protocol. Participants included 13 youths with a history of mTBI three to six months prior to testing and 14 typically-developing controls. All participants completed a working memory task in isolation (single-task) and while completing a concurrent motor task (dual-task); neural activity during performance was then compared between groups. Although working memory performance was similar during the single-task condition, increased working memory load resulted in an altered pattern of neural activation in key working memory areas (i.e., dorsolateral prefrontal and parietal cortices) in youth with mTBI relative to controls. During the dual-task condition, accuracy was similar between groups but injured youth performed slower than typically-developing controls, suggesting a speed-accuracy tradeoff in the mTBI group only. The injured youths also exhibited abnormal recruitment of brain structures involved in both working memory and dual-tasking. These data show that the dual-task paradigm can uncover functional impairments in youth with mTBI who are not highly symptomatic and who do not exhibit neuropsychological dysfunction. Moreover, neural recruitment abnormalities were noted in both task conditions, which we argue suggests mTBI-related disruptions in achieving efficient cognitive control and allocation of processing resources. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bigler, Erin D; Deibert, Ellen
Lesion analysis in mild traumatic brain injury: Old school goes high tech Journal Article
In: Neurology, vol. 83, no. 14, pp. 1226–1227, 2014, ISBN: 0028-3878 1526-632X.
Abstract | Links | BibTeX | Tags: 2014, ALGORITHMS, brain, functional magnetic resonance imaging, gray matter, mild traumatic brain injury, MRI, traumatic brain injury, white matter
@article{Bigler2014,
title = {Lesion analysis in mild traumatic brain injury: Old school goes high tech},
author = {Bigler, Erin D and Deibert, Ellen},
doi = {10.1212/WNL.0000000000000848},
isbn = {0028-3878
1526-632X},
year = {2014},
date = {2014-01-01},
journal = {Neurology},
volume = {83},
number = {14},
pages = {1226--1227},
publisher = {Lippincott Williams \& Wilkins},
address = {US},
abstract = {Comments on an article by Y. W. Lui et al. (see record [rid]2014-43480-004[/rid]). Concussion has been a controversial topic in neurology since the beginning of the discipline. Evidence based diagnostic guidelines have been established,1 but the diagnosis and treatment are largely grounded in clinical decision-making. Clinical and research issues around sports concussion have even reached the levels of government policy with the White House. At the moderate to severe range of traumatic brain injury, neuroimaging provides well-established, objective pathoanatomical biomarkers of the injury. In contrast, conventional neuroimaging findings in mTBI are typically absent. The cognitive and neurobehavioral symptoms of mTBI overlap with any number of neurologic or psychiatric disorders, providing no definitive marker of injury or for tracking injury effects. Reliable biomarkers of mTBI could lead to better clinical decision-making and potential treatments. Deformation-based biomechanical studies of mTBI have shown the thalamus is situated in a particularly vulnerable zone. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2014, ALGORITHMS, brain, functional magnetic resonance imaging, gray matter, mild traumatic brain injury, MRI, traumatic brain injury, white matter},
pubstate = {published},
tppubtype = {article}
}
Sinopoli, Katia J; Chen, Jen-Kai; Wells, Greg; Fait, Philippe; Ptito, Alain; Taha, Tim; Keightley, Michelle
Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance Journal Article
In: Journal of Neurotrauma, vol. 31, no. 22, pp. 1843–1859, 2014, ISBN: 0897-7151 1557-9042.
Abstract | Links | BibTeX | Tags: 2014, Athletes, dual task, Dual Task Performance, fMRI, functional magnetic resonance imaging, mild TBI, short term memory, traumatic brain injury, working memory
@article{Sinopoli2014,
title = {Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance},
author = {Sinopoli, Katia J and Chen, Jen-Kai and Wells, Greg and Fait, Philippe and Ptito, Alain and Taha, Tim and Keightley, Michelle},
doi = {10.1089/neu.2014.3326},
isbn = {0897-7151
1557-9042},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neurotrauma},
volume = {31},
number = {22},
pages = {1843--1859},
publisher = {Mary Ann Liebert, Inc.},
address = {US},
abstract = {Mild traumatic brain injury (mTBI) is a common cause of injury in youth athletes. Much of what is known about the sequelae of mTBI is yielded from the adult literature, and it appears that it is mainly those with persistent post-injury symptoms who have ongoing cognitive and neural abnormalities. However, most studies have employed single-task paradigms, which may not be challenging enough to uncover subtle deficits. We sought to examine the neural correlates of dual-task performance in male athletes aged 9-15 years using a functional neuroimaging protocol. Participants included 13 youths with a history of mTBI three to six months prior to testing and 14 typically-developing controls. All participants completed a working memory task in isolation (single-task) and while completing a concurrent motor task (dual-task); neural activity during performance was then compared between groups. Although working memory performance was similar during the single-task condition, increased working memory load resulted in an altered pattern of neural activation in key working memory areas (i.e., dorsolateral prefrontal and parietal cortices) in youth with mTBI relative to controls. During the dual-task condition, accuracy was similar between groups but injured youth performed slower than typically-developing controls, suggesting a speed-accuracy tradeoff in the mTBI group only. The injured youths also exhibited abnormal recruitment of brain structures involved in both working memory and dual-tasking. These data show that the dual-task paradigm can uncover functional impairments in youth with mTBI who are not highly symptomatic and who do not exhibit neuropsychological dysfunction. Moreover, neural recruitment abnormalities were noted in both task conditions, which we argue suggests mTBI-related disruptions in achieving efficient cognitive control and allocation of processing resources. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2014, Athletes, dual task, Dual Task Performance, fMRI, functional magnetic resonance imaging, mild TBI, short term memory, traumatic brain injury, working memory},
pubstate = {published},
tppubtype = {article}
}